{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:42:37Z","timestamp":1786542157866,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008658","name":"German Cancer Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01GN0942"],"award-info":[{"award-number":["01GN0942"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009398","name":"RWTH Aachen University Medical Faculty","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006004","name":"Rob and Bessie Welder Wildlife Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejcb.2026.151546","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:27:38Z","timestamp":1780759658000},"page":"151546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The plaque protein myozap defines unique junction strands in smooth muscle cell bundles"],"prefix":"10.1016","volume":"105","author":[{"given":"Werner W.","family":"Franke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Rickelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"D\u00f6rflinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caecilia","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Winter-Simanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Zimbelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Breitscheidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-7379","authenticated-orcid":false,"given":"Rudolf E.","family":"Leube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2026.151546_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112390","article-title":"Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice","volume":"9","author":"Borlepawar","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ejcb.2026.151546_bib2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ejcb.2006.02.009","article-title":"The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk","volume":"85","author":"Borrmann","year":"2006","journal-title":"Eur. J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib3","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E23-05-0163","article-title":"Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience","volume":"34","author":"Brooks","year":"2023","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151546_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/aja.1001490110","article-title":"Light and electron microscopic observations on noradrenergic nerves and striated muscle cells of the guinea pig urethra","volume":"149","author":"Dixon","year":"1977","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.ejcb.2026.151546_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00441-018-2968-x","article-title":"The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system","volume":"375","author":"Domke","year":"2019","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.ejcb.2026.151546_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.17.2.375","article-title":"Junctional complexes in various epithelia","volume":"17","author":"Farquhar","year":"1963","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.yjmcc.2014.03.016","article-title":"Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy","volume":"72","author":"Frank","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejcb.2026.151546_bib8","doi-asserted-by":"crossref","first-page":"a003061","DOI":"10.1101\/cshperspect.a003061","article-title":"Discovering the molecular components of intercellular junctions--a historical view","volume":"1","author":"Franke","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejcb.2005.11.003","article-title":"The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins","volume":"85","author":"Franke","year":"2006","journal-title":"Eur. J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib10","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1002\/ijc.26227","article-title":"Mesenchymal-epithelial transitions: spontaneous and cumulative syntheses of epithelial marker molecules and their assemblies to novel cell junctions connecting human hematopoietic tumor cells to carcinomatoid tissue structures","volume":"129","author":"Franke","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejcb.2026.151546_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00224298","article-title":"Structural changes in smooth muscle cells during isotonic contraction","volume":"170","author":"Gabella","year":"1976","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.ejcb.2026.151546_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/biom13020294","article-title":"The actin network interfacing diverse integrin-mediated adhesions","volume":"13","author":"Geiger","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejcb.2026.151546_bib13","doi-asserted-by":"crossref","first-page":"a002576","DOI":"10.1101\/cshperspect.a002576","article-title":"Gap junctions","volume":"1","author":"Goodenough","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib14","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1083\/jcb.201808061","article-title":"Talin as a mechanosensitive signaling hub","volume":"217","author":"Goult","year":"2018","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1083\/jcb.42.3.683","article-title":"Ultrastructural studies on the contractile mechanism of smooth muscle","volume":"42","author":"Kelly","year":"1969","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.yjmcc.2019.01.028","article-title":"Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy","volume":"129","author":"Kluge","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejcb.2026.151546_bib17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1078\/0171-9335-00330","article-title":"Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas","volume":"82","author":"Langbein","year":"2003","journal-title":"Eur. J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000145904","article-title":"The muscle layer of the canine gallbladder and cystic duct","volume":"120","author":"MacPherson","year":"1984","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.ejcb.2026.151546_bib19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/nau.20739","article-title":"Interstitial cells in the urinary bladder--localization and function","volume":"29","author":"McCloskey","year":"2010","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejcb.2026.151546_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-3-642-16499-6_11","article-title":"Interstitial cells of Cajal in the urinary tract","author":"McCloskey","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ejcb.2026.151546_bib21","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1083\/jcb.120.5.1159","article-title":"Complementary distributions of vinculin and dystrophin define two distinct sarcolemma domains in smooth muscle","volume":"120","author":"North","year":"1993","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1091\/mbc.E17-06-0356","article-title":"An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse","volume":"29","author":"Osmani","year":"2018","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151546_bib23","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.240208","article-title":"Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks","volume":"15","author":"Outla","year":"2025","journal-title":"Open. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib24","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1111\/j.1582-4934.2011.01463.x","article-title":"The plaque protein myozap identified as a novel major component of adhering junctions in endothelia of the blood and the lymph vascular systems","volume":"16","author":"Pieperhoff","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejcb.2026.151546_bib25","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1083\/jcb.201303052","article-title":"Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy","volume":"203","author":"Rangrez","year":"2013","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib26","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1074\/jbc.M115.689620","article-title":"Myozap deficiency promotes adverse cardiac remodeling via differential regulation of mitogen-activated protein kinase\/serum-response factor and beta-catenin\/GSK-3beta protein signaling","volume":"291","author":"Rangrez","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2026.151546_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00441-008-0736-z","article-title":"Ultrastructure of Cajal-like interstitial cells in the human detrusor","volume":"335","author":"Rasmussen","year":"2009","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.ejcb.2026.151546_bib28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00441-011-1281-8","article-title":"Protein myozap--a late addition to the molecular ensembles of various kinds of adherens junctions","volume":"346","author":"Rickelt","year":"2011","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.ejcb.2026.151546_bib29","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/modpathol.2010.138","article-title":"A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata","volume":"23","author":"Rickelt","year":"2010","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ejcb.2026.151546_bib30","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/ijc.24552","article-title":"Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell-cell-attachment characteristic for transformed mesenchymal cells","volume":"125","author":"Rickelt","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejcb.2026.151546_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06485.x","article-title":"Perspectives on tight junction research","volume":"1257","author":"Schulzke","year":"2012","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.ejcb.2026.151546_bib32","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/CIRCRESAHA.109.213256","article-title":"Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo","volume":"106","author":"Seeger","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejcb.2026.151546_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/j.1460-2075.1985.tb02315.x","article-title":"Geometry of actin-membrane attachments in the smooth muscle cell: the localisations of vinculin and alpha-actinin","volume":"4","author":"Small","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2026.151546_bib34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-201X.1998.00441.x","article-title":"The cytoskeleton of the vertebrate smooth muscle cell","volume":"164","author":"Small","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejcb.2026.151546_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells12060942","article-title":"Caveolae mechanotransduction at the interface between cytoskeleton and extracellular matrix","volume":"12","author":"Sotodosos-Alonso","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ejcb.2026.151546_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jemt.10089","article-title":"Structure and function of endothelial caveolae","volume":"57","author":"Stan","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ejcb.2026.151546_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s003840000237","article-title":"Vascular organization in the mesorectum: angiography of rectal resection specimens","volume":"15","author":"Sterk","year":"2000","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.ejcb.2026.151546_bib38","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1083\/jcb.201106023","article-title":"E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells","volume":"195","author":"Straub","year":"2011","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1247\/csf.26.61","article-title":"Localization of plectin and other related proteins along the sarcolemma in smooth muscle cells of rat colon","volume":"26","author":"Tanaka","year":"2001","journal-title":"Cell. Struct. Funct."},{"key":"10.1016\/j.ejcb.2026.151546_bib40","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1083\/jcb.97.3.887","article-title":"Occurrence and immunolocalization of plectin in tissues","volume":"97","author":"Wiche","year":"1983","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151546_bib41","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2022.5116","article-title":"Talin\u20111 interaction network in cellular mechanotransduction (Review)","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:23:17Z","timestamp":1786540997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933526000178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0171933526000178"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151546","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The plaque protein myozap defines unique junction strands in smooth muscle cell bundles","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151546"}}