{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:43:01Z","timestamp":1786542181787,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["191620045965"],"award-info":[{"award-number":["191620045965"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["221610061747"],"award-info":[{"award-number":["221610061747"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/015(0545)\/2019-EMR-I"],"award-info":[{"award-number":["09\/015(0545)\/2019-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/015(0534)\/2019-EMR-I"],"award-info":[{"award-number":["09\/015(0534)\/2019-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejcb.2026.151548","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:07:44Z","timestamp":1781222864000},"page":"151548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethanol stress-induced vacuole unlobing is mediated via downregulation of phosphatidylinositol-3,5-bisphosphate and Atg18 phospho-regulation"],"prefix":"10.1016","volume":"105","author":[{"given":"Pritha","family":"Mandal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babai","family":"Hazra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurupa","family":"Sett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabanita","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok Kumar","family":"Sil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srimonti","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2026.151548_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0092-8674(00)80913-7","article-title":"Signaling via mitogen-activated protein kinase kinase (MEK1) is required for golgi fragmentation during mitosis","volume":"92","author":"Acharya","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2026.151548_bib2","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1074\/jbc.M113.453712","article-title":"Vac14 protein multimerization is a prerequisite step for fab1 protein complex assembly and function","volume":"288","author":"Alghamdi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2026.151548_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jbiosc.2017.03.009","article-title":"Molecular mechanisms of the yeast adaptive response and tolerance to stresses encountered during ethanol fermentation","volume":"124","author":"Auesukaree","year":"2017","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ejcb.2026.151548_bib4","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.bbamcr.2019.02.011","article-title":"The vacuolar shapes of ageing: from function to morphology","volume":"1866","author":"Aufschnaiter","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"10.1016\/j.ejcb.2026.151548_bib5","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1091\/mbc.e07-03-0205","article-title":"Role of the V-ATPase in Regulation of the Vacuolar Fission\u2013Fusion Equilibrium","volume":"18","author":"Baars","year":"2007","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.molcel.2012.05.027","article-title":"Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy","volume":"47","author":"Baskaran","year":"2012","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/13014","article-title":"The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast","volume":"1","author":"Bleazard","year":"1999","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib8","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1083\/jcb.200201002","article-title":"Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p","volume":"156","author":"Bonangelino","year":"2002","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib9","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1091\/mbc.e08-04-0405","article-title":"Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase","volume":"19","author":"Botelho","year":"2008","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cell.2012.01.047","article-title":"Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains","volume":"149","author":"Boucrot","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2026.151548_bib11","series-title":"Methods in yeast genetics: a cold spring harbor laboratory course manual, 2000 ed. ed","author":"Burke","year":"2000"},{"key":"10.1016\/j.ejcb.2026.151548_bib12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/cdd.2012.31","article-title":"A higher spirit: avoiding yeast suicide during alcoholic fermentation","volume":"19","author":"Carmona-Gutierrez","year":"2012","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.ejcb.2026.151548_bib13","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.febslet.2009.12.035","article-title":"Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1","volume":"584","author":"Chang","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejcb.2026.151548_bib14","doi-asserted-by":"crossref","first-page":"27590","DOI":"10.1074\/jbc.274.39.27590","article-title":"Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase","volume":"274","author":"Corson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2026.151548_bib15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1083\/jcb.138.3.517","article-title":"A multispecificity syntaxin homologue, Vam3p, Essential for autophagic and biosynthetic protein transport to the vacuole","volume":"138","author":"Darsow","year":"1997","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/36613","article-title":"Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis","volume":"390","author":"Dove","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2026.151548_bib17","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/sj.emboj.7600203","article-title":"Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors","volume":"23","author":"Dove","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2026.151548_bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1128\/EC.5.4.723-731.2006","article-title":"Phosphoinositide 5-phosphatase Fig. 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels","author":"Duex","year":"2006","journal-title":"Eukaryot. Cell. 5"},{"key":"10.1016\/j.ejcb.2026.151548_bib19","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1091\/mbc.e07-04-0301","article-title":"Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-Bisphosphate","volume":"18","author":"Efe","year":"2007","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2020.106379","article-title":"Ethanol induced changes in structural, morphological, and functional properties of whey proteins isolates: Influence of ethanol concentration","volume":"111","author":"Feng","year":"2021","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ejcb.2026.151548_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.143.1.65","article-title":"Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis","volume":"143","author":"Gary","year":"1998","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib22","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0196-0644(86)80120-2","article-title":"Effect of alcohol on cellular membranes","volume":"15","author":"Goldstein","year":"1986","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.ejcb.2026.151548_bib23","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.15252\/embj.201796859","article-title":"Membrane scission driven by the PROPPIN Atg18","volume":"36","author":"Gopaldass","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2026.151548_bib24","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260889","article-title":"Yck3 casein kinase-mediated phosphorylation determines Ivy1 localization and function at endosomes and the vacuole","volume":"136","author":"Grziwa","year":"2023","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ejcb.2026.151548_bib25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.201503088","article-title":"Mdm1\/Snx13 is a novel ER\u2013endolysosomal interorganelle tethering protein","volume":"210","author":"Henne","year":"2015","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0854.2011.01246.x","article-title":"Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2","volume":"13","author":"Ho","year":"2012","journal-title":"Traffic"},{"key":"10.1016\/j.ejcb.2026.151548_bib27","doi-asserted-by":"crossref","DOI":"10.1101\/2024.06.13.598808","article-title":"PI(3,5)P2 asymmetry during mitosis is essential for asymmetric vacuolar inheritance","volume":"224","author":"Huda","year":"2024","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib28","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1038\/emboj.2008.248","article-title":"VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse","volume":"27","author":"Jin","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2026.151548_bib29","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.258325","article-title":"Large organellar changes occur during mild heat shock in yeast","volume":"135","author":"Keuenhof","year":"2022","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ejcb.2026.151548_bib30","doi-asserted-by":"crossref","first-page":"E2042","DOI":"10.1073\/pnas.1205128109","article-title":"Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a \u03b2-propeller protein family","volume":"109","author":"Krick","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejcb.2026.151548_bib31","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1242\/jcs.03166","article-title":"Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae","volume":"119","author":"Kuravi","year":"2006","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ejcb.2026.151548_bib32","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1091\/mbc.e16-06-0390","article-title":"An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels","volume":"28","author":"Lang","year":"2017","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib33","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbamcr.2008.08.003","article-title":"The yeast lysosome-like vacuole: endpoint and crossroads","volume":"1793","author":"Li","year":"2009","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Lysosomes"},{"key":"10.1016\/j.ejcb.2026.151548_bib34","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U","article-title":"Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae","volume":"14","author":"Longtine","year":"1998","journal-title":"Yeast"},{"key":"10.1016\/j.ejcb.2026.151548_bib35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbamem.2004.08.002","article-title":"Membrane fluidity and its roles in the perception of environmental signals","volume":"1666","author":"Los","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejcb.2026.151548_bib36","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1073\/pnas.1722517115","article-title":"Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor","volume":"115","author":"Malia","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2026.151548_bib37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/15548627.2022.2072656","article-title":"Vacuole fragmentation depends on a novel Atg18-containing retromer-complex","volume":"19","author":"Marquardt","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.ejcb.2026.151548_bib38","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/(SICI)1097-0061(19990915)15:12<1211::AID-YEA448>3.0.CO;2-H","article-title":"Endocytosis and vacuolar morphology in Saccharomyces cerevisiae are altered in response to ethanol stress or heat shock","volume":"15","author":"Meaden","year":"1999","journal-title":"Yeast"},{"key":"10.1016\/j.ejcb.2026.151548_bib39","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1091\/mbc.e11-08-0703","article-title":"Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1","volume":"23","author":"Michaillat","year":"2012","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib40","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/febs.13987","article-title":"Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics","volume":"284","author":"Nascimbeni","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.ejcb.2026.151548_bib41","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/1751-7915.13032","article-title":"Membrane fluidification by ethanol stress activates unfolded protein response in yeasts","volume":"11","author":"Navarro-Tapia","year":"2018","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ejcb.2026.151548_bib42","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1091\/mbc.E14-08-1262","article-title":"Hsp70 clears misfolded kinases that partitioned into distinct quality-control compartments","volume":"26","author":"Roy","year":"2015","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib43","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1242\/jcs.070045","article-title":"Atg8 regulates vacuolar membrane dynamics in a lipidation-independent manner in Pichia pastoris","volume":"123","author":"Tamura","year":"2010","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ejcb.2026.151548_bib44","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.201302067","article-title":"Atg18 phosphoregulation controls organellar dynamics by modulating its phosphoinositide-binding activity","volume":"202","author":"Tamura","year":"2013","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib45","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.128.5.779","article-title":"A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast","volume":"128","author":"Vida","year":"1995","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib46","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202209077","article-title":"A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes","volume":"222","author":"Vines","year":"2023","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib47","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1083\/jcb.139.3.665","article-title":"Homotypic lysosome fusion in macrophages: analysis using an in vitro assay","volume":"139","author":"Ward","year":"1997","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151548_bib48","doi-asserted-by":"crossref","first-page":"31681","DOI":"10.1074\/jbc.M112.397570","article-title":"Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18","volume":"287","author":"Watanabe","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2026.151548_bib49","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.genet.37.050203.103207","article-title":"Yeast vacuole inheritance and dynamics","volume":"37","author":"Weisman","year":"2003","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.ejcb.2026.151548_bib50","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1091\/mbc.e12-05-0347","article-title":"Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements","volume":"23","author":"Zieger","year":"2012","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ejcb.2026.151548_bib51","doi-asserted-by":"crossref","first-page":"17472","DOI":"10.1073\/pnas.1203106109","article-title":"vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P","volume":"109","author":"Zolov","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:24:54Z","timestamp":1786541094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933526000191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0171933526000191"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151548","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethanol stress-induced vacuole unlobing is mediated via downregulation of phosphatidylinositol-3,5-bisphosphate and Atg18 phospho-regulation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151548","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151548"}}