{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:00:37Z","timestamp":1790830837001,"version":"4.1.0"},"reference-count":224,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejcb.2026.151561","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:19:01Z","timestamp":1786465141000},"page":"151561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trained immunity in autoinflammatory diseases: Cellular reprogramming across the monogenic\u2013polygenic spectrum"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-7746","authenticated-orcid":false,"given":"Ferenc","family":"Sipos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgyi","family":"M\u0171zes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2026.151561_bib1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fimmu.2017.00318","article-title":"Genetic and Epigenetic Determinants in Autoinflammatory Diseases","volume":"8","author":"\u00c1lvarez-Errico","year":"2017","journal-title":"Front. Immunol."},{"issue":"20","key":"10.1016\/j.ejcb.2026.151561_bib2","doi-asserted-by":"crossref","first-page":"15186","DOI":"10.3390\/ijms242015186","article-title":"Endoplasmic Reticulum Stress Promotes the Expression of TNF-\u03b1 in THP-1 Cells by Mechanisms Involving ROS\/CHOP\/HIF-1\u03b1 and MAPK\/NF-\u03baB Pathways","volume":"24","author":"Akhter","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5152\/ArchRheumatol.2026.25179","article-title":"Modulation of Inflammasome Activity by miR-197-3p in Familial Mediterranean Fever Mouse Macrophages","volume":"41","author":"Akkaya-Ulum","year":"2026","journal-title":"Arch. Rheumatol."},{"key":"10.1016\/j.ejcb.2026.151561_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/JPR.S186372","article-title":"Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy","volume":"12","author":"Alvarado-V\u00e1zquez","year":"2018","journal-title":"J. Pain. Res."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151561_bib5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","article-title":"Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity","volume":"24","author":"Arts","year":"2016","journal-title":"Cell. Metab."},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib6","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.celrep.2016.11.011","article-title":"Immunometabolic Pathways in BCG-Induced Trained Immunity","volume":"17","author":"Arts","year":"2016","journal-title":"Cell. Rep."},{"key":"10.1016\/j.ejcb.2026.151561_bib7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fimmu.2018.00298","article-title":"The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders","volume":"9","author":"Arts","year":"2018","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib8","first-page":"378","article-title":"A Review of HIF-1\u03b1-Mediated Integration of Metabolic Reprogramming, Mitochondrial Function, and PI3K\/Akt-MAPK-Nrf2-NF-\u03baB Signaling","volume":"15","author":"Ashraf","year":"2026","journal-title":"Antioxid. (Basel Switz. )"},{"key":"10.1016\/j.ejcb.2026.151561_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1533620","article-title":"Trained immunity in diabetes: emerging targets for cardiovascular complications","volume":"16","author":"Bai","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.ejcb.2026.151561_bib10","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng.175","article-title":"Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease","volume":"40","author":"Barrett","year":"2008","journal-title":"Nat. Genet."},{"issue":"29","key":"10.1016\/j.ejcb.2026.151561_bib11","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2020.35.e213","article-title":"Neutrophil-mediated Thrombosis and NETosis in Beh\u00e7et's Disease: a Hypothesis","volume":"35","author":"Batu","year":"2020","journal-title":"J. Korean Med. Sci."},{"issue":"8","key":"10.1016\/j.ejcb.2026.151561_bib12","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","article-title":"Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes","volume":"34","author":"Bekkering","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejcb.2026.151561_bib13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.atherosclerosis.2016.10.019","article-title":"Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo","volume":"254","author":"Bekkering","year":"2016","journal-title":"Atherosclerosis"},{"issue":"1-2","key":"10.1016\/j.ejcb.2026.151561_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cell.2017.11.025","article-title":"Metabolic Induction of Trained Immunity through the Mevalonate Pathway","volume":"172","author":"Bekkering","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2026.151561_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2025.110549","article-title":"Etiopathogenesis of Beh\u00e7et's disease: A systematic literature review","volume":"279","author":"Belfeki","year":"2025","journal-title":"Clinical immunology (Orlando Fla. )"},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/jpids\/piy142","article-title":"Maternal Priming: Bacillus Calmette-Gu\u00e9rin (BCG) Vaccine Scarring in Mothers Enhances the Survival of Their Child With a BCG Vaccine Scar","volume":"9","author":"Berendsen","year":"2020","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/imr.70095","article-title":"Trained Immunity and Cardiovascular Risk: An Immunological Perspective","volume":"337","author":"Boden","year":"2026","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib18","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/biomedicines14020480","article-title":"Periodontitis-Induced Immune Reprogramming: Implications for Cancer Immunotherapy Response","volume":"14","author":"Bogdan-Andreescu","year":"2026","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s40265-025-02169-x","article-title":"Current Drug Treatment for Acute and Recurrent Pericarditis","volume":"85","author":"Bonaventura","year":"2025","journal-title":"Drugs"},{"issue":"2 2","key":"10.1016\/j.ejcb.2026.151561_bib20","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.jaci.2009.09.017","article-title":"Adaptive immunity","volume":"125","author":"Bonilla","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10875-019-00638-z","article-title":"CAPS and NLRP3","volume":"39","author":"Booshehri","year":"2019","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib22","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3389\/fimmu.2019.01119","article-title":"Chromatin Architecture as an Essential Determinant of Dendritic Cell Function","volume":"10","author":"Boukhaled","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib23","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1038\/s41598-020-62727-z","article-title":"CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout","volume":"10","author":"Bousoik","year":"2020","journal-title":"Sci. Rep."},{"issue":"26","key":"10.1016\/j.ejcb.2026.151561_bib24","first-page":"00023","article-title":"Interleukin-1: from discovery to therapeutic targeting of the first cytokine","volume":"S1323-8930","author":"Broderick","year":"2026","journal-title":"Allergol. Int. Off. J. Jpn. Soc. Allergol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/imr.12833","article-title":"Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia","volume":"294","author":"Cab\u0103u","year":"2020","journal-title":"Immunol. Rev."},{"issue":"9","key":"10.1016\/j.ejcb.2026.151561_bib26","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1172\/JCI134778","article-title":"\u03b2-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies","volume":"130","author":"Camilli","year":"2020","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.autrev.2012.07.020","article-title":"Tumour necrosis factor receptor-associated periodic syndrome (TRAPS): state of the art and future perspectives","volume":"12","author":"Cantarini","year":"2012","journal-title":"Autoimmun. Rev."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151561_bib28","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221388","article-title":"Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis","volume":"220","author":"Chakraborty","year":"2023","journal-title":"J. Exp. Med."},{"issue":"25","key":"10.1016\/j.ejcb.2026.151561_bib29","first-page":"00734","article-title":"Trained immunity modulators: A new frontier in immunoregulation and disease intervention","volume":"S2090-1232","author":"Chen","year":"2025","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib30","doi-asserted-by":"crossref","first-page":"E117","DOI":"10.1152\/ajpendo.00071.2025","article-title":"Maladaptive trained immunity of adipose tissue macrophages unraveling the link to obesity, T2DM, and beyond","volume":"329","author":"Chen","year":"2025","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"6204","key":"10.1016\/j.ejcb.2026.151561_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science (New York N. Y. )"},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib32","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/ATVBAHA.120.314211","article-title":"Diabetes and Metabolic Drivers of Trained Immunity: New Therapeutic Targets Beyond Glucose","volume":"41","author":"Choudhury","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.ejcb.2026.151561_bib33","article-title":"Inflammation reprogramming and immunomodulation: Next-generation treatments for atherosclerosis","volume":"6","author":"Choudhury","year":"2025","journal-title":"Cell. Rep. Med."},{"issue":"1-2","key":"10.1016\/j.ejcb.2026.151561_bib34","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2026.151561_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.599947","article-title":"Interleukin 17 Promotes Expression of Alarmins S100A8 and S100A9 During the Inflammatory Response of Keratinocytes","volume":"11","author":"Christmann","year":"2021","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110489","article-title":"Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response","volume":"38","author":"Cobo","year":"2022","journal-title":"Cell. Rep."},{"key":"10.1016\/j.ejcb.2026.151561_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaut.2018.03.002","article-title":"Gain of function mutation and inflammasome driven diseases in human and mouse models","volume":"91","author":"Cordero","year":"2018","journal-title":"J. Autoimmun."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib38","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3390\/biom13050770","article-title":"Glucose Transporter Glut1-Dependent Metabolic Reprogramming Regulates Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages","volume":"13","author":"Cornwell","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cei.13149","article-title":"Stroma: the forgotten cells of innate immune memory","volume":"193","author":"Crowley","year":"2018","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.ejcb.2026.151561_bib40","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.3390\/ijms21093263","article-title":"Revisiting TNF Receptor-Associated Periodic Syndrome (TRAPS): Current Perspectives","volume":"21","author":"Cudrici","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib41","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/jdv.17779","article-title":"Primary alterations during the development of hidradenitis suppurativa","volume":"36","author":"Dajnoki","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"10.1016\/j.ejcb.2026.151561_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1578202","article-title":"Metabolic reprogramming in viral infections: the interplay of glucose metabolism and immune responses","volume":"16","author":"Darweesh","year":"2025","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151561_bib43","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1093\/jimmun\/vkaf135","article-title":"Epigenetic and metabolic regulation of macrophage responsiveness and memory","volume":"214","author":"Daskalaki","year":"2025","journal-title":"Journal immunology (Baltimore Md. 1950)"},{"issue":"12","key":"10.1016\/j.ejcb.2026.151561_bib44","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1136\/ard-2024-225853","article-title":"Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR\/PReS recommendations for the diagnosis and management of Still's disease","volume":"83","author":"De Matteis","year":"2024","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41590-020-00845-6","article-title":"Trained immunity, tolerance, priming and differentiation: distinct immunological processes","volume":"22","author":"Divangahi","year":"2021","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cmet.2018.09.003","article-title":"The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity","volume":"29","author":"Dom\u00ednguez-Andr\u00e9s","year":"2019","journal-title":"Cell. Metab."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib47","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imr.12607","article-title":"The NLRC4 Inflammasome","volume":"281","author":"Duncan","year":"2018","journal-title":"Immunol. Rev."},{"issue":"7","key":"10.1016\/j.ejcb.2026.151561_bib48","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/ard-2023-225305","article-title":"Systemic inflammatory cytokine profiles in patients with gout during flare, intercritical and treat-to-target phases: TNFSF14 as new biomarker","volume":"83","author":"Ea","year":"2024","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.ejcb.2026.151561_bib49","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.120.046464","article-title":"Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis","volume":"144","author":"Edgar","year":"2021","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib50","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.molcel.2016.05.029","article-title":"Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes","volume":"62","author":"Etchegaray","year":"2016","journal-title":"Mol. Cell."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2020.10.011","article-title":"The Intersection of Epigenetics and Metabolism in Trained Immunity","volume":"54","author":"Fanucchi","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.ejcb.2026.151561_bib52","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2147\/TACG.S93933","article-title":"Mevalonate kinase deficiency: current perspectives","volume":"9","author":"Favier","year":"2016","journal-title":"Appl. Clin. Genet."},{"issue":"3-4","key":"10.1016\/j.ejcb.2026.151561_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00281-024-01015-8","article-title":"Metabolic Regulation in the Induction of Trained Immunity","volume":"46","author":"Ferreira","year":"2024","journal-title":"Semin. Immunopathol."},{"issue":"12","key":"10.1016\/j.ejcb.2026.151561_bib54","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.stemcr.2024.09.004","article-title":"Interleukin-1\u03b2 induces trained innate immunity in human hematopoietic progenitor cells in vitro","volume":"19","author":"Flores-Gomez","year":"2024","journal-title":"Stem Cell. Rep."},{"issue":"7","key":"10.1016\/j.ejcb.2026.151561_bib55","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202154339","article-title":"Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice","volume":"23","author":"Frising","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ejcb.2026.151561_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.868343","article-title":"Trained Immunity Contribution to Autoimmune and Inflammatory Disorders","volume":"13","author":"Funes","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib57","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13075-019-1885-z","article-title":"Targeting inflammatory pathways in axial spondyloarthritis","volume":"21","author":"Furst","year":"2019","journal-title":"Arthritis Res. & Ther."},{"key":"10.1016\/j.ejcb.2026.151561_bib58","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.3389\/fimmu.2018.02422","article-title":"Dynamics of Inflammatory Response in Autoinflammatory Disorders: Autonomous and Hyperinflammatory States","volume":"9","author":"G\u00fcl","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib59","doi-asserted-by":"crossref","DOI":"10.37349\/emd.2025.1007103","article-title":"Targeting innate immune memory: a new paradigm for gout treatment","volume":"3","author":"Gaal","year":"2025","journal-title":"Explor. Musculoskelet. Dis."},{"issue":"9","key":"10.1016\/j.ejcb.2026.151561_bib60","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.3390\/jcm10091880","article-title":"Autoinflammatory Features in Gouty Arthritis","volume":"10","author":"Galozzi","year":"2021","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2020.101529","article-title":"Systemic autoinflammatory diseases: Clinical state of the art","volume":"34","author":"Georgin-Lavialle","year":"2020","journal-title":"Best. Pract. & Res. Clin. Rheumatol."},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib62","first-page":"659","article-title":"Cryopyrin-associated periodic syndrome","volume":"16","author":"Giat","year":"2014","journal-title":"Isr. Med. Assoc. J. IMAJ"},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib63","article-title":"Elevated serum levels of interleukin-18 discriminate Still's disease from other autoinflammatory conditions: results from the European ImmunAID cohort","volume":"11","author":"Girard-Guyonvarc'h","year":"2025","journal-title":"RMD Open."},{"issue":"12","key":"10.1016\/j.ejcb.2026.151561_bib64","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151561_bib65","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.3390\/ijms25116102","article-title":"Generation of iPSCs from a Patient with the M694V Mutation in the MEFV Gene Associated with Familial Mediterranean Fever and Their Differentiation into Macrophages","volume":"25","author":"Grigor'eva","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib66","doi-asserted-by":"crossref","first-page":"271","DOI":"10.31138\/mjr.34.2.271","article-title":"Investigating the role of \"Immature Myeloid Cells\" as Drivers of Inflammation and Disease Persistence in Psoriatic Arthritis","volume":"34","author":"Grivas","year":"2023","journal-title":"Mediterr. J. Rheumatol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib67","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20210025","article-title":"oxLDL-Induced Trained Immunity Is Dependent on Mitochondrial Metabolic Reprogramming","volume":"3","author":"Groh","year":"2021","journal-title":"Immunometabolism"},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113139","article-title":"MSU crystal deposition contributes to inflammation and immune responses in gout remission","volume":"42","author":"Gu","year":"2023","journal-title":"Cell. Rep."},{"issue":"16","key":"10.1016\/j.ejcb.2026.151561_bib69","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1097\/CM9.0000000000000964","article-title":"A novel mouse model of hyperuricemia and gouty nephropathy","volume":"133","author":"Guan","year":"2020","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib70","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","article-title":"Signaling pathways and targeted therapies for psoriasis","volume":"8","author":"Guo","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"24","key":"10.1016\/j.ejcb.2026.151561_bib71","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.3390\/cells11244072","article-title":"Innate Immune Memory in Monocytes and Macrophages: The Potential Therapeutic Strategies for Atherosclerosis","volume":"11","author":"Guo","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.ejcb.2026.151561_bib72","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib73","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jaci.2024.06.005","article-title":"Central trained immunity and its impact on chronic inflammatory and autoimmune diseases","volume":"154","author":"Hajishengallis","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib74","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/prd.12421","article-title":"Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities","volume":"89","author":"Hajishengallis","year":"2022","journal-title":"Periodontology 2000"},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib75","doi-asserted-by":"crossref","DOI":"10.1093\/jleuko\/qiaf037","article-title":"Metabolic adaptations driving innate immune memory: mechanisms and therapeutic implications","volume":"117","author":"Hao","year":"2025","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib76","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/icb.2011.112","article-title":"The interplay between endoplasmic reticulum stress and inflammation","volume":"90","author":"Hasnain","year":"2012","journal-title":"Immunol. Cell. Biol."},{"issue":"6627","key":"10.1016\/j.ejcb.2026.151561_bib77","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.abj8894","article-title":"Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation","volume":"379","author":"Hata","year":"2023","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib78","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cyto.2014.06.012","article-title":"Ex vivo PBMC cytokine profile in familial Mediterranean fever patients: Involvement of IL-1\u03b2, IL-1\u03b1 and Th17-associated cytokines and decrease of Th1 and Th2 cytokines","volume":"69","author":"Ibrahim","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.ejcb.2026.151561_bib79","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.3389\/fimmu.2019.01330","article-title":"Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes","volume":"10","author":"Ieronymaki","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2025.105993","article-title":"Connecting the dots: Gouty arthritis, clonal haematopoiesis and myeloid activation, in a unified inflammation model for atherosclerosis progression","volume":"93","author":"Inkum","year":"2025","journal-title":"Jt. Bone Spine"},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib81","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.15419\/17639y26","article-title":"Inflammation demystified: An in-depth comprehensive review","volume":"12","author":"Jameel","year":"2025","journal-title":"Biomed. Res. Ther."},{"key":"10.1016\/j.ejcb.2026.151561_bib82","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clim.2018.02.001","article-title":"Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy","volume":"196","author":"Jeffries","year":"2018","journal-title":"Clinical immunology (Orlando Fla. )"},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib83","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1093\/rheumatology\/keab696","article-title":"Long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency: results from the randomised Phase 3 CLUSTER trial","volume":"61","author":"Jeyaratnam","year":"2022","journal-title":"Rheumatol. (Oxf. Engl. )"},{"key":"10.1016\/j.ejcb.2026.151561_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583513","article-title":"Roles of Interactions Between Toll-Like Receptors and Their Endogenous Ligands in the Pathogenesis of Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease","volume":"11","author":"Jung","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib85","first-page":"196","article-title":"Beyond Tuberculosis: The Surprising Immunological Benefits of the Bacillus Calmette-Gu\u00e9rin (BCG) Vaccine in Infectious, Auto-Immune, and Inflammatory Diseases","volume":"14","author":"Jurczak","year":"2025","journal-title":"Pathog. (Basel Switz. )"},{"issue":"9","key":"10.1016\/j.ejcb.2026.151561_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107596","article-title":"Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models","volume":"26","author":"Kain","year":"2023","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib87","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2020.09.058","article-title":"Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity","volume":"183","author":"Kalafati","year":"2020","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ejcb.2026.151561_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101194","article-title":"Recurrent Pericarditis and Paradigm Shift in Cardiovascular Imaging and Targeted Therapeutics","volume":"3","author":"Karmali","year":"2024","journal-title":"Jacc. Adv."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib89","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/cr.2010.61","article-title":"Survive an innate immune response through XBP1","volume":"20","author":"Kaser","year":"2010","journal-title":"Cell. Res."},{"issue":"1-2","key":"10.1016\/j.ejcb.2026.151561_bib90","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ejcb.2026.151561_bib91","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell. Res."},{"issue":"22","key":"10.1016\/j.ejcb.2026.151561_bib92","doi-asserted-by":"crossref","first-page":"16382","DOI":"10.3390\/ijms242216382","article-title":"Beh\u00e7et's Disease: A Comprehensive Review on the Role of HLA-B*51, Antigen Presentation, and Inflammatory Cascade","volume":"24","author":"Khoshbakht","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib93","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1038\/s12276-025-01542-w","article-title":"Trained immunity induced by DAMPs and LAMPs in chronic inflammatory diseases","volume":"57","author":"Kim","year":"2025","journal-title":"Exp. & Mol. Med."},{"issue":"23","key":"10.1016\/j.ejcb.2026.151561_bib94","doi-asserted-by":"crossref","first-page":"13038","DOI":"10.3390\/ijms222313038","article-title":"An Update on the Pathogenic Role of Neutrophils in Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151561_bib95","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.956795","article-title":"Interleukin-6 inhibition in the treatment of autoinflammatory diseases","volume":"13","author":"Koga","year":"2022","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib96","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3234","article-title":"Evaluation of DNA methylation status of toll-like receptors 2 and 4 promoters in Behcet's disease","volume":"22","author":"Kolahi","year":"2020","journal-title":"J. gene Med."},{"key":"10.1016\/j.ejcb.2026.151561_bib97","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1393283","article-title":"Endotoxin tolerance and trained immunity: breaking down immunological memory barriers","volume":"15","author":"L\u00f3pez-Collazo","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib98","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","article-title":"NK cell recognition","volume":"23","author":"Lanier","year":"2005","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib99","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jaci.2020.07.033","article-title":"Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1","volume":"146","author":"Lee","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1466844","article-title":"Mevalonate kinase deficiency: an updated clinical overview and revision of the SHARE recommendations","volume":"15","author":"Lengv\u00e1ri","year":"2024","journal-title":"Front. Immunol."},{"issue":"14","key":"10.1016\/j.ejcb.2026.151561_bib101","doi-asserted-by":"crossref","first-page":"7688","DOI":"10.3390\/ijms22147688","article-title":"Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151561_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.626240","article-title":"The mTORC1\/eIF4E\/HIF-1\u03b1 Pathway Mediates Glycolysis to Support Brain Hypoxia Resistance in the Gansu Zokor, Eospalax cansus","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejcb.2026.151561_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105452","article-title":"NF-\u03baB c-Rel is a critical regulator of TLR7-induced inflammation in psoriasis","volume":"110","author":"Liu","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejcb.2026.151561_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109698","article-title":"ATF4 knockdown in macrophage impairs glycolysis and mediates immune tolerance by targeting HK2 and HIF-1\u03b1 ubiquitination in sepsis","volume":"254","author":"Liu","year":"2023","journal-title":"Clinical immunology (Orlando Fla. )"},{"key":"10.1016\/j.ejcb.2026.151561_bib105","article-title":"Trained immunity: novel perspectives in diabetes and associated complications","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib106","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joca.2017.10.013","article-title":"Hierarchical, imbalanced pro-inflammatory cytokine networks govern the pathogenesis of chronic arthropathies","volume":"26","author":"Livshits","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejcb.2026.151561_bib107","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1472-6750-13-68","article-title":"The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase","volume":"13","author":"Maciejak","year":"2013","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.ejcb.2026.151561_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2024.107419","article-title":"Macrophages in vascular disease: Roles of mitochondria and metabolic mechanisms","volume":"156","author":"Mackay","year":"2024","journal-title":"Vasc. Pharmacol."},{"issue":"8","key":"10.1016\/j.ejcb.2026.151561_bib109","doi-asserted-by":"crossref","DOI":"10.1111\/exd.70160","article-title":"Trained Immunity and Its Potential Implications in the Etiopathogenesis of Hidradenitis Suppurativa: A New Paradigm in Chronic Inflammation?","volume":"34","author":"Marcuzzi","year":"2025","journal-title":"Exp. Dermatol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib110","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.7150\/thno.40650","article-title":"A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1\u03b2 as relevant therapy for gout patients","volume":"10","author":"Mariotte","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib111","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.24185","article-title":"Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout","volume":"60","author":"Martin","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib112","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/art.30249","article-title":"Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout","volume":"63","author":"Martin","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejcb.2026.151561_bib113","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-065X.2000.917309.x","article-title":"Innate immune recognition: mechanisms and pathways","volume":"173","author":"Medzhitov","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ejcb.2026.151561_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2024.1448176","article-title":"The riddle of recurrent fever: a clinical approach to pediatric autoinflammatory diseases","volume":"12","author":"Meertens","year":"2024","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.ejcb.2026.151561_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.648341","article-title":"Beh\u00e7et's Disease-Do Microbiomes and Genetics Collaborate in Pathogenesis?","volume":"12","author":"Mehmood","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib116","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2147\/JIR.S506103","article-title":"Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments","volume":"18","author":"Miao","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.ejcb.2026.151561_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1558263","article-title":"Understanding chronic inflammation: couplings between cytokines, ROS, NO, Cai2+, HIF-1\u03b1, Nrf2 and autophagy","volume":"16","author":"Michalak","year":"2025","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib118","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1182\/blood-2002-02-0651","article-title":"Allogeneic bone marrow transplantation: cure for familial Mediterranean fever","volume":"100","author":"Milledge","year":"2002","journal-title":"Blood"},{"issue":"1-2","key":"10.1016\/j.ejcb.2026.151561_bib119","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/imm.70108","article-title":"TREM-1 Blockade Inhibits Inflammasome Activation and Pyroptosis: Novel Insights on the Role of TREM-1 and Syk in Monosodium Urate Crystal-Induced Inflammation","volume":"178","author":"Molad","year":"2026","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib121","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41467-024-44990-0","article-title":"Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1\u03b2 production","volume":"15","author":"Molina-L\u00f3pez","year":"2024","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.ejcb.2026.151561_bib122","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.cell.2019.05.024","article-title":"Piwi\/PRG-1 Argonaute and TGF-\u03b2 Mediate Transgenerational Learned Pathogenic Avoidance","volume":"177","author":"Moore","year":"2019","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ejcb.2026.151561_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107634","article-title":"\u03b2-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1","volume":"31","author":"Moorlag","year":"2020","journal-title":"Cell. Rep."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib124","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/bjd\/ljad184","article-title":"Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin","volume":"189","author":"Moran","year":"2023","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib125","doi-asserted-by":"crossref","first-page":"C40","DOI":"10.1152\/ajpcell.00416.2025","article-title":"Role of persistent necroinflammation in chronic tissue remodeling and organ fibrosis","volume":"330","author":"More","year":"2026","journal-title":"Am. J. Physiol. Cell. Physiol."},{"issue":"21","key":"10.1016\/j.ejcb.2026.151561_bib126","doi-asserted-by":"crossref","first-page":"11386","DOI":"10.3390\/ijms252111386","article-title":"Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism","volume":"25","author":"Mosalmanzadeh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib127","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s41927-025-00515-w","article-title":"Canakinumab treatment patterns in sJIA, FMF, TRAPS, and MKD\/HIDS: real-world insights from a Belgian non-interventional study","volume":"9","author":"Moutschen","year":"2025","journal-title":"BMC Rheumatol."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib128","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00281-015-0492-6","article-title":"Hyper-IgD syndrome\/mevalonate kinase deficiency: what is new?","volume":"37","author":"Mulders-Manders","year":"2015","journal-title":"Semin. Immunopathol."},{"issue":"19","key":"10.1016\/j.ejcb.2026.151561_bib129","doi-asserted-by":"crossref","DOI":"10.1172\/JCI160929","article-title":"Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency","volume":"132","author":"Munoz","year":"2022","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151561_bib130","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1189\/jlb.0313153","article-title":"Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation","volume":"94","author":"Muralidharan","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"15","key":"10.1016\/j.ejcb.2026.151561_bib131","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.3390\/jcm12155039","article-title":"Reversing the Inflammatory Process-25 Years of Tumor Necrosis Factor-\u03b1 Inhibitors","volume":"12","author":"Muth","year":"2023","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib132","doi-asserted-by":"crossref","DOI":"10.1186\/ar3898","article-title":"Enhanced interleukin-1\u03b2 production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals","volume":"14","author":"Mylona","year":"2012","journal-title":"Arthritis Res. & Ther."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib133","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cmet.2014.03.029","article-title":"Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity","volume":"19","author":"Nagareddy","year":"2014","journal-title":"Cell. Metab."},{"issue":"7918","key":"10.1016\/j.ejcb.2026.151561_bib134","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-022-04919-3","article-title":"Inflammatory memory and tissue adaptation in sickness and in health","volume":"607","author":"Naik","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2026.151561_bib135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12889-015-1497-8","article-title":"Child survival and BCG vaccination: a community based prospective cohort study in Uganda","volume":"15","author":"Nankabirwa","year":"2015","journal-title":"BMC Public. Health"},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112393","article-title":"Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring","volume":"42","author":"Nash","year":"2023","journal-title":"Cell. Rep."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib137","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","article-title":"Trained immunity: a memory for innate host defense","volume":"9","author":"Netea","year":"2011","journal-title":"Cell. host & Microbe"},{"issue":"6284","key":"10.1016\/j.ejcb.2026.151561_bib138","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: A program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science (New York N. Y. )"},{"issue":"6","key":"10.1016\/j.ejcb.2026.151561_bib139","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib140","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1684\/ecn.2009.0163","article-title":"Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation","volume":"20","author":"Normand","year":"2009","journal-title":"Eur. Cytokine Netw."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib141","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.gene.6363813","article-title":"Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever","volume":"3","author":"Notarnicola","year":"2002","journal-title":"Genes. Immun."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib142","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.cell.2016.09.034","article-title":"\u03b2-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance","volume":"167","author":"Novakovic","year":"2016","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib143","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1136\/annrheumdis-2012-202774","article-title":"Increased NLRP3-dependent interleukin 1\u03b2 secretion in patients with familial Mediterranean fever: correlation with MEFV genotype","volume":"73","author":"Omenetti","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib144","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s40744-024-00733-7","article-title":"Long-Term Safety and Effectiveness of Canakinumab in Patients with MKD\/HIDS: Interim Analysis of the RELIANCE Registry","volume":"12","author":"Oommen","year":"2025","journal-title":"Rheumatol. Ther."},{"key":"10.1016\/j.ejcb.2026.151561_bib145","doi-asserted-by":"crossref","DOI":"10.2147\/JIR.S540879","article-title":"Elucidating the Role of Neutrophils in the Inflammatory Response to Behcet Syndrome","volume":"19","author":"Ozguler","year":"2026","journal-title":"J. Inflamm. Res."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151561_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103901","article-title":"Systemic auto-inflammatory diseases, auto-immune diseases and immune deficiencies: From independent to overlapped diseases approach","volume":"24","author":"Parentelli","year":"2025","journal-title":"Autoimmun. Rev."},{"issue":"8","key":"10.1016\/j.ejcb.2026.151561_bib147","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ni.3457","article-title":"Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS","volume":"17","author":"Park","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib148","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1633318","article-title":"Decoding the inflammatory-osteogenic axis in ankylosing spondylitis: mechanisms, dysregulation, and emerging therapeutic interventions","volume":"16","author":"Parvin","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib149","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fimmu.2017.00036","article-title":"Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation","volume":"8","author":"Pellegrini","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib150","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/ijerph18031170","article-title":"Gene Expression Analysis of Mevalonate Kinase Deficiency Affected Children Identifies Molecular Signatures Related to Hematopoiesis","volume":"18","author":"Pisanti","year":"2021","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.ejcb.2026.151561_bib151","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.724991","article-title":"Compromised Protein Prenylation as Pathogenic Mechanism in Mevalonate Kinase Deficiency","volume":"12","author":"Politiek","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib152","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1379220","article-title":"Mevalonate kinase-deficient THP-1 cells show a disease-characteristic pro-inflammatory phenotype","volume":"15","author":"Politiek","year":"2024","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167177","article-title":"Molecular and cellular consequences of mevalonate kinase deficiency","volume":"1870","author":"Politiek","year":"2024","journal-title":"Biochim. Et. Biophys. Acta Mol. basis Dis."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib154","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s13555-025-01566-0","article-title":"Cardiovascular Disease and Psoriasis","volume":"16","author":"Ponikowska","year":"2026","journal-title":"Dermatol. Ther."},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib155","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/art.43215","article-title":"Gout and NLRP3 Inflammasome Biology","volume":"77","author":"Poulsen","year":"2025","journal-title":"Arthritis & Rheumatol. (Hoboken N. J. )"},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib156","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.cell.2020.09.059","article-title":"Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition","volume":"183","author":"Priem","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib157","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41420-023-01489-9","article-title":"Histone demethylases in the regulation of immunity and inflammation","volume":"9","author":"Qu","year":"2023","journal-title":"Cell. death Discov."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109356","article-title":"Epigenetic, transcriptional, and functional characterization of myeloid cells in familial Mediterranean fever","volume":"27","author":"R\u00f6ring","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.ejcb.2026.151561_bib159","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9259646","article-title":"Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations","volume":"2016","author":"Rider","year":"2016","journal-title":"Int. J. Cell. Biol."},{"key":"10.1016\/j.ejcb.2026.151561_bib160","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100897","article-title":"Immunometabolic control of trained immunity","volume":"77","author":"Riksen","year":"2021","journal-title":"Mol. Asp. Med."},{"issue":"12","key":"10.1016\/j.ejcb.2026.151561_bib161","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41569-023-00894-y","article-title":"Trained immunity in atherosclerotic cardiovascular disease","volume":"20","author":"Riksen","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151561_bib162","article-title":"Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies","volume":"37","author":"Robinson","year":"2023","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib163","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.immuni.2024.12.012","article-title":"Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow","volume":"58","author":"Robles-Vera","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.ejcb.2026.151561_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.553742","article-title":"Innate Cells: The Alternative Source of IL-17 in Axial and Peripheral Spondyloarthritis?","volume":"11","author":"Rosine","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib165","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41413-026-00543-3","article-title":"From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy","volume":"14","author":"Roy","year":"2026","journal-title":"Bone Res."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib166","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41591-022-01724-3","article-title":"Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19","volume":"28","author":"Sacco","year":"2022","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib167","doi-asserted-by":"crossref","first-page":"509","DOI":"10.31138\/mjr.020525.ahr","article-title":"Advancing Precision Medicine in Adult-Onset Still's Disease: Insights into Biomarkers, Therapies, and COVID-19 Impacts","volume":"36","author":"Sahoo","year":"2025","journal-title":"Mediterr. J. Rheumatol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib168","doi-asserted-by":"crossref","first-page":"8216","DOI":"10.1038\/s41598-026-39580-7","article-title":"Integrative profiling of transcriptome and H3K27ac modification reveals changes associated with BCG-induced trained immunity in bovine immune cells","volume":"16","author":"Samuel","year":"2026","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib169","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/gucdd3030011","article-title":"Inter-Critical Gout, Not Hyperuricemia or Asymptomatic Urate Crystal Deposition, Is Associated with Systemic Inflammation","volume":"3","author":"Sandoval-Plata","year":"2025","journal-title":"Gout Urate Cryst. Depos. Dis."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib170","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/annrheumdis-2021-220578","article-title":"Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles","volume":"81","author":"Saper","year":"2022","journal-title":"Ann. Rheum. Dis."},{"issue":"26","key":"10.1016\/j.ejcb.2026.151561_bib171","first-page":"00015","article-title":"The IL-36 cytokine family: From barrier immunity to therapeutic target in inflammatory diseases","volume":"S1323-8930","author":"Satoh","year":"2026","journal-title":"Allergol. Int. Off. J. Jpn. Soc. Allergol."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151561_bib172","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41422-025-01171-y","article-title":"Trained immunity: induction of an inflammatory memory in disease","volume":"35","author":"Schl\u00fcter","year":"2025","journal-title":"Cell. Res."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151561_bib173","doi-asserted-by":"crossref","first-page":"iv67","DOI":"10.1093\/rheumatology\/keaa408","article-title":"Intestinal and enthesis innate immunity in early axial spondyloarthropathy","volume":"59","author":"Sharif","year":"2020","journal-title":"Rheumatol. (Oxf. Engl. )"},{"issue":"6","key":"10.1016\/j.ejcb.2026.151561_bib174","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/cimb48060642","article-title":"Metformin as an Innate Immune Modulator: Metabolic and Epigenetic Reprogramming of Innate Immune Cells and Therapeutic Implications","volume":"48","author":"Shi","year":"2026","journal-title":"Curr. Issues Mol. Biol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib175","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-77272-2","article-title":"Transcutaneous auricular vagus nerve stimulation mitigates gouty inflammation by reducing neutrophil infiltration in BALB\/c mice","volume":"14","author":"Shin","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib176","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/imm.13142","article-title":"Highly oxidized low-density lipoprotein mediates activation of monocytes but does not confer interleukin-1\u03b2 secretion nor interleukin-15 transpresentation function","volume":"159","author":"Sieg","year":"2020","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.ejcb.2026.151561_bib177","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.molmet.2014.06.005","article-title":"Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells","volume":"3","author":"Singer","year":"2014","journal-title":"Mol. Metab."},{"issue":"26","key":"10.1016\/j.ejcb.2026.151561_bib178","first-page":"00066","article-title":"Epigenetic and Transcriptional Regulatory Networks Underlying Psoriasis Pathogenesis","volume":"S0002-9440","author":"Singh","year":"2026","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib179","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.194677","article-title":"Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum","volume":"11","author":"Snouwaert","year":"2026","journal-title":"JCI Insight"},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib180","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201466","article-title":"Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome","volume":"218","author":"Stackowicz","year":"2021","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151561_bib181","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3390\/nu13062045","article-title":"The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society","volume":"13","author":"Strasser","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ejcb.2026.151561_bib182","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.coi.2020.02.002","article-title":"The epigenetically-encoded memory of the innate immune system","volume":"65","author":"Sun","year":"2020","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib183","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13023-019-1169-3","article-title":"Enhanced migration and adhesion of peripheral blood neutrophils from SAPHO patients revealed by RNA-Seq","volume":"14","author":"Sun","year":"2019","journal-title":"Orphanet J. rare Dis."},{"key":"10.1016\/j.ejcb.2026.151561_bib184","doi-asserted-by":"crossref","unstructured":"Sun (\u5b59\u674e\u54f2), L., Yang (\u6768\u6653\u5cf0), X., Yuan (\u8881\u7956\u8d3b), Z., & Wang (\u738b\u8679), H. (2020). Metabolic Reprogramming in Immune Response and Tissue Inflammation. Arteriosclerosis, thrombosis, and vascular biology, 40(9), 1990\u20132001. https:\/\/doi.org\/10.1161\/ATVBAHA.120.314037.","DOI":"10.1161\/ATVBAHA.120.314037"},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib185","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/jimmun\/vkaf156","article-title":"Diet-induced obesity induces oxidative stress and enhances H3K4me3 levels, driving nonresolving inflammation and myelopoiesis in hematopoietic stem and progenitor cells","volume":"214","author":"Takahashi","year":"2025","journal-title":"Journal immunology (Baltimore Md. 1950)"},{"issue":"21","key":"10.1016\/j.ejcb.2026.151561_bib186","doi-asserted-by":"crossref","first-page":"9789","DOI":"10.1073\/pnas.1000779107","article-title":"Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion","volume":"107","author":"Tassi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2026.151561_bib187","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejim.2023.11.014","article-title":"Pyrin-associated autoinflammatory disease with p.Thr577Ala MEFV somatic mutation","volume":"120","author":"Terr\u00e9","year":"2024","journal-title":"Eur. J. Intern. Med."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib188","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/annrheumdis-2016-209335","article-title":"Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome","volume":"76","author":"Torene","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejcb.2026.151561_bib189","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.106610","article-title":"Hematopoietic stem and progenitor cells as a reservoir for trained immunity","volume":"14","author":"Tran","year":"2025","journal-title":"eLife"},{"issue":"12","key":"10.1016\/j.ejcb.2026.151561_bib190","doi-asserted-by":"crossref","first-page":"23274","DOI":"10.3390\/ijms141223274","article-title":"Mevalonate kinase deficiency and neuroinflammation: balance between apoptosis and pyroptosis","volume":"14","author":"Tricarico","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151561_bib191","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.953730","article-title":"Activation mechanisms of monocytes\/macrophages in adult-onset Still disease","volume":"13","author":"Tsuboi","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib192","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4274\/balkanmedj.galenos.2025.2025-11-133","article-title":"Familial Mediterranean Fever: A Comprehensive Review of Pathogenesis, Genetics, and Epigenetic Regulation","volume":"43","author":"Ugurlu","year":"2026","journal-title":"Balk. Med. J."},{"issue":"40","key":"10.1016\/j.ejcb.2026.151561_bib193","doi-asserted-by":"crossref","first-page":"27757","DOI":"10.1074\/jbc.M114.571810","article-title":"Unprenylated RhoA contributes to IL-1\u03b2 hypersecretion in mevalonate kinase deficiency model through stimulation of Rac1 activity","volume":"289","author":"van der Burgh","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2026.151561_bib194","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.108465","article-title":"Trained Immunity: RoadMap for drug discovery and development","volume":"14","author":"van Puffelen","year":"2025","journal-title":"Elife"},{"issue":"10","key":"10.1016\/j.ejcb.2026.151561_bib195","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3390\/ijms20102565","article-title":"Trained Innate Immunity Not Always Amicable","volume":"20","author":"W\u0142odarczyk","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151561_bib196","article-title":"Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib197","article-title":"Spatiotemporal immune gradients in gout: immune response-driven activation of the NLRP3-IL-1\u03b2 axis and its transition to trained immunity","volume":"17","author":"Wang","year":"2026","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib198","article-title":"The role of trained immunity in sepsis","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib199","article-title":"Therapeutic approaches for SAPHO syndrome from the perspective of pathogenesis: a review of the literature","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib200","first-page":"774","article-title":"Efficacy of Xixiancao (Herba Siegesbeckiae Orientalis) on interactions between nuclear factor kappa-B and inflammatory cytokines in inflammatory reactions of rat synovial cells induced by sodium urate","volume":"40","author":"Wang","year":"2020","journal-title":"J. Tradit. Chin. Med. = Chung i tsa chih ying wen pan"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib201","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41392-023-01647-6","article-title":"Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib202","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/gutjnl-2016-312518","article-title":"Molecular classification of Crohn's disease reveals two clinically relevant subtypes","volume":"67","author":"Weiser","year":"2018","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib203","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/jcm10010128","article-title":"Diagnosis and Management of the Cryopyrin-Associated Periodic Syndromes (CAPS): What Do We Know Today?","volume":"10","author":"Welzel","year":"2021","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib204","doi-asserted-by":"crossref","DOI":"10.1093\/immhor\/vlag005","article-title":"Sustained monocyte activation by persistent challenges with either oxLDL or free cholesterol and underlying mechanisms","volume":"10","author":"Wu","year":"2026","journal-title":"ImmunoHorizons"},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib205","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/imm.13722","article-title":"Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity","volume":"171","author":"Xia","year":"2024","journal-title":"Immunology"},{"key":"10.1016\/j.ejcb.2026.151561_bib206","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2304018","article-title":"Emerging Roles of Redox-Mediated Angiogenesis and Oxidative Stress in Dermatoses","volume":"2019","author":"Xian","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151561_bib207","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/gucdd4010008","article-title":"Non-Hyperuricemia Experimental Models of Gout","volume":"4","author":"Xiang","year":"2026","journal-title":"Gout Urate Cryst. Depos. Dis."},{"key":"10.1016\/j.ejcb.2026.151561_bib208","article-title":"Reversing inflammatory diseases via trained immunity: mechanisms, challenges, and prospects","volume":"16","author":"Xu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib209","article-title":"Glycolysis and NLRP3 inflammasome activation in diseases","author":"Xu","year":"2026","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.ejcb.2026.151561_bib210","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.1038\/ncomms8652","article-title":"NF-\u03baB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis","volume":"6","author":"Yan","year":"2015","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.ejcb.2026.151561_bib211","doi-asserted-by":"crossref","first-page":"9663","DOI":"10.3390\/ijms26199663","article-title":"Memory in Misfire: The Gut Microbiome-Trained Immunity Circuit in Inflammatory Bowel Diseases","volume":"26","author":"Yang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib212","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s12016-020-08825-2","article-title":"Inflammasomes and Childhood Autoimmune Diseases: A Review of Current Knowledge","volume":"61","author":"Yang","year":"2021","journal-title":"Clin. Rev. Allergy & Immunol."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151561_bib213","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/sj.embor.7400687","article-title":"Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK","volume":"7","author":"Yang","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ejcb.2026.151561_bib214","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1259434","article-title":"Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2026.151561_bib215","article-title":"The role of cytokines in the pathogenesis of SAPHO syndrome","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151561_bib216","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70461","article-title":"Trained Immunity in Health and Disease","volume":"6","author":"Yao","year":"2025","journal-title":"MedComm"},{"issue":"2","key":"10.1016\/j.ejcb.2026.151561_bib217","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/rheumatology\/kez282","article-title":"IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome","volume":"59","author":"Yasin","year":"2020","journal-title":"Rheumatol. (Oxf. Engl. )"},{"issue":"21-22","key":"10.1016\/j.ejcb.2026.151561_bib218","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1101\/gad.352841.125","article-title":"H3K4me3 amplifies transcription at intergenic active regulatory elements","volume":"39","author":"Yu","year":"2025","journal-title":"Genes. & Dev."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151561_bib219","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.581","article-title":"Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis","volume":"10","author":"Yu","year":"2022","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.ejcb.2026.151561_bib220","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109161","article-title":"Transcriptional analysis of neutrophils from patients with Beh\u00e7et's disease reveals activation and chemotaxis of neutrophils","volume":"245","author":"Yu","year":"2022","journal-title":"Clinical immunology (Orlando Fla. )"},{"issue":"5","key":"10.1016\/j.ejcb.2026.151561_bib221","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/1535370219830665","article-title":"Phagocytosis of monosodium urate crystals by human synoviocytes induces inflammation","volume":"244","author":"Zamudio-Cuevas","year":"2019","journal-title":"Exp. Biol. Med. (Maywood N. J. )"},{"issue":"7","key":"10.1016\/j.ejcb.2026.151561_bib222","article-title":"Enhanced Trained Immunity in Peripheral Monocytes in Unstable Angina With Elevated High-Sensitivity C-Reactive Protein","volume":"10","author":"Zhang","year":"2025","journal-title":"Jacc. Basic. Transl. Sci."},{"key":"10.1016\/j.ejcb.2026.151561_bib223","article-title":"Histone deacetylases and their inhibitors in inflammatory diseases","volume":"179","author":"Zhang","year":"2024","journal-title":"Biomed. & Pharmacother. = Biomedecine & Pharmacother."},{"key":"10.1016\/j.ejcb.2026.151561_bib224","article-title":"AIM2 and Psoriasis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:35:08Z","timestamp":1790829308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933526000324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":224,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0171933526000324"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151561","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trained immunity in autoinflammatory diseases: Cellular reprogramming across the monogenic\u2013polygenic spectrum","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151561"}}