{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:58:03Z","timestamp":1770065883044,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It remains unclear whether tumor necrosis factor (TNF)-\u03b1 and interleukin-6 (IL-6) are secreted from the failing heart and whether there is a relationship between the transcardiac gradients of these cytokines and left ventricular (LV) remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the relationship between transcardiac gradients of cytokines and LV volume and function in congestive heart failure patients with dilated cardiomyopathy (DCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We measured the plasma levels of TNF-\u03b1 and IL-6 in the aortic root (Ao) and the coronary sinus (CS) in 60 patients with DCM. There was no difference in plasma IL-6 between the Ao and the CS. However, the plasma TNF-\u03b1 level was significantly higher in the CS than that in the Ao. There was a significant correlation between the transcardiac gradient of plasma TNF-\u03b1 and the LV end-diastolic volume index (LVEDVI) and LV ejection fraction. According to stepwise multivariate analyses, the transcardiac increase of TNF-\u03b1 showed an independent and significantly positive relationship with a large LVEDVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that the elevated plasma TNF-\u03b1 is partly derived from the failing heart in patients with DCM and that TNF-\u03b1 plays a potential role in structural LV remodeling in patients with DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2003.10.004","type":"journal-article","created":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T07:26:08Z","timestamp":1071041168000},"page":"173-180","source":"Crossref","is-referenced-by-count":16,"title":["Transcardiac Increase in Tumor Necrosis Factor-\u03b1 and Left Ventricular end-Diastolic Volume in Patients with Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"6","author":[{"given":"Takayoshi","family":"Tsutamoto","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuyuki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitose","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keijin","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Seta-Tsukinowa, Otsu, 520-2192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Dohke","sequence":"additional","affiliation":[{"name":"Department of 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