{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:18:05Z","timestamp":1770059885393,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about sex-related differences in factors affecting prognosis of heart failure (HF). We prospectively investigated the relationship between bedside clinical variables and survival of older females vs. males with HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Included were consecutive unselected inpatients, age \u226560 years, admitted for various acute conditions. HF was chronic and of diverse etiologies. Follow-up extended up to 5 years. All-cause mortality was registered and statistically analyzed for association with in-hospital clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Included were 162 females and 200 males. Survival rates were 52.4% and 59%, respectively, (P=0.1). Advanced age and renal dysfunction (RD) were associated with low survival in both sexes (P&amp;lt;0.03 and 0.02, P&amp;lt;0.001 and 0.01, respectively). An association with low survival was found with respect to; admission for pulmonary edema (P&amp;lt;0.02), using furosemide \u226580 mg\/day (P&amp;lt;0.005) and severe HF [NYHA class III\u2013IV (P&amp;lt;0.01)] in females, as well as for hypokalemia (P&amp;lt;0.03) and hypocalcemia (P&amp;lt;0.03) in males. On multivariate analysis RD (P&amp;lt;0.001), increasing age (P=0.008) and furosemide dosage \u226580 mg (P=0.02) were most significantly associated with low survival in females, while RD only was significantly associated with low survival in males (P=0.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several clinical variables, which affect prognosis in older HF patients are sex-related and probably carry practical significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2003.12.023","type":"journal-article","created":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T11:26:14Z","timestamp":1091705174000},"page":"781-786","source":"Crossref","is-referenced-by-count":4,"title":["Sex-Related Bedside Clinical Variables Associated with Survival of Older Inpatients with Heart Failure"],"prefix":"10.1093","volume":"6","author":[{"given":"Natan","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Ilgiyaev","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Almoznino-Sarafian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Alon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Shteinshnaider","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulamit","family":"Chachashvily","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Modai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Gorelik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2018F\u2019, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University , 70300 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,11,12]]},"reference":[{"key":"2026020204011003000_ejhf2003-12-023-bib-0001","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1056\/NEJM199307223290406","article-title":"Cardiovascular health and disease in women","volume":"329","author":"Wenger","year":"1993","journal-title":"N Engl J Med"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0002","doi-asserted-by":"crossref","first-page":"48J","DOI":"10.1016\/S0002-9149(01)01884-7","article-title":"Women and cardiovascular risk","volume":"88","author":"Welty","year":"2001","journal-title":"Am J Cardiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0003","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1161\/01.CIR.0000014121.94868.81","article-title":"Women, heart failure and heart failure therapies","volume":"105","author":"Wenger","year":"2002","journal-title":"Circulation"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0004","doi-asserted-by":"crossref","first-page":"6A","DOI":"10.1016\/0735-1097(93)90455-A","article-title":"The epidemiology of heart failure: the Framingham Study","volume":"22","author":"Ho","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0005","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0002-8703(99)70007-4","article-title":"Sex differences in the clinical care and outcomes of congestive heart failure in the elderly","volume":"138","author":"Vaccarino","year":"1999","journal-title":"Am Heart J"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0006","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.1996.03530440037034","article-title":"The progression from hypertension to congestive heart failure","volume":"275","author":"Levy","year":"1996","journal-title":"J Am Med Assoc"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0007","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/0002-8703(93)90414-5","article-title":"Spectrum and outcome of congestive heart failure in a hospitalized population","volume":"126","author":"Andersson","year":"1993","journal-title":"Am Heart J"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0008","first-page":"1417","article-title":"Where are all the women with heart failure=","volume":"30","author":"Lindenfeld","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0009","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1076-7460.2002.00053.x","article-title":"Clinical profile of chronic heart failure in elderly women","volume":"11","author":"Tandon","year":"2002","journal-title":"Am J Geriatr Cardiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0010","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1053\/euhj.2000.2533","article-title":"The prognosis of heart failure in the general population: The Rotterdam Study","volume":"22","author":"Mosterd","year":"2001","journal-title":"Eur Heart J"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0011","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0735-1097(99)00608-7","article-title":"The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction","volume":"35","author":"Dries","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0012","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/S0735-1097(96)00380-4","article-title":"Relation between gender, etiology and survival in patients with symptomatic heart failure","volume":"28","author":"Adams","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0013","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/01.CIR.103.3.375","article-title":"Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II)","volume":"103","author":"Simon","year":"2001","journal-title":"Circulation"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0014","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1067\/mhj.2002.123144","article-title":"PRAISI Investigators. Prospective Randomized Amlodipine Survival Evaluation. Diuretic resistance predicts mortality in patients with advanced heart failure","volume":"144","author":"Neuberg","year":"2002","journal-title":"Am Heart J"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/heart.89.4.411","article-title":"Serum magnesium aberrations in furosemide (frusemide) treated patients with congestive heart failure: pathophysiological correlates and prognostic evaluation","volume":"89","author":"Cohen","year":"2003","journal-title":"Heart"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0016","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0002-9343(02)01498-5","article-title":"The prognostic importance of anemia in patients with heart failure","volume":"114","author":"Kosiborod","year":"2003","journal-title":"Am J Med"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0017","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1161\/01.CIR.99.14.1816","article-title":"Gender differences in survival in advanced heart failure. Insights from the FIRST Study","volume":"99","author":"Adams","year":"1999","journal-title":"Circulation"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0018","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1056\/NEJMoa021266","article-title":"Sex-based differences in the effect of digoxin for the treatment of heart failure","volume":"347","author":"Rathore","year":"2002","journal-title":"N Engl J Med"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0019","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1540-8167.2000.tb01750.x","article-title":"Gender-related differences in modulation of heart rate in patients with congestive heart failure","volume":"11","author":"Aronson","year":"2000","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1026585420021","article-title":"Gender-related differences in proliferative response of cardiac fibroblasts to hypoxia: effects of estrogen","volume":"215","author":"Griffin","year":"2000","journal-title":"Mol Cell Biochem"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0021","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1006\/jmcc.2001.1394","article-title":"Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium","volume":"33","author":"Dash","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0022","doi-asserted-by":"crossref","first-page":"31883","DOI":"10.1074\/jbc.M101058200","article-title":"Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones","volume":"276","author":"Song","year":"2001","journal-title":"J Biol Chem"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0023","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/01.CIR.86.4.1099","article-title":"Sex-associated differences in left ventricular function in aortic stenosis of the elderly","volume":"86","author":"Carroll","year":"1992","journal-title":"Circulation"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0024","first-page":"101","article-title":"Gender effect on diuretic response to hydrochlorothiazide and furosemide","volume":"34","author":"Franson","year":"1996","journal-title":"Int J Clin Pharmacol Ther"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/phrs.2001.0912","article-title":"Effects of gender on the pharmacokinetics of drugs secreted by the renal organic anions transport systems in the rat","volume":"45","author":"Cerrutti","year":"2002","journal-title":"Pharmacol Res"},{"issue":"2 Pt 2","key":"2026020204011003000_ejhf2003-12-023-bib-0026","first-page":"II53, II60","article-title":"Left ventricular hypertrophy in hypertension. Prevalence and relationship to pathophysiologic variables","volume":"9","author":"Devereux","year":"1987","journal-title":"Hypertension"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0027","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/1071-9164(95)90014-4","article-title":"Interobserver discordance in the classification of mechanisms of death in studies of heart failure","volume":"1","author":"Ziesche","year":"1995","journal-title":"J Card Fail"},{"key":"2026020204011003000_ejhf2003-12-023-bib-0028","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0167-5273(99)00129-1","article-title":"The prognostic implications of outpatient diuretic dose in heart failure","volume":"71","author":"Harjai","year":"1999","journal-title":"Int J Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejheart.2003.12.023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/6\/6\/781\/66649324\/eurjhf_6_6_781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/6\/6\/781\/66649324\/eurjhf_6_6_781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:01:18Z","timestamp":1770022878000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/6\/6\/781\/8446690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,1]]},"references-count":28,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,11,12]]},"published-print":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ejheart.2003.12.023","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,10]]},"published":{"date-parts":[[2004,10,1]]}}}