{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:10:16Z","timestamp":1772619016087,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brain natriuretic peptide (BNP) is a cardiac hormone secreted from the ventricular myocardium as a response to ventricular volume expansion and pressure overload. Rheumatic heart disease (RHD) is still an important cause of heart failure in developing countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To measure BNP levels in patients with RHD and to determine whether BNP concentrations correlate with clinical and echocardiographic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-eight patients with rheumatic valve disease and 24 age- and sex-matched healthy subjects were entered in the study. BNP was measured using the Triage B-Type Natriuretic Peptide test (Biosite Diagnostics, San Diego, CA). Transthoracic echocardiography was performed in all patients to assess the severity of the valve disease and for the measurement of pulmonary artery pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The plasma concentrations of BNP were significantly higher in patients with rheumatic heart disease than in control subjects (232\u00b1294 vs. 14\u00b112 pg\/ml, p&amp;lt;0.0001). The plasma BNP level was significantly higher in NYHA class III+IV than in class II (463\u00b1399 vs. 192\u00b1243 pg\/ml, p&amp;lt;0.0001) and in NYHA class II than in class I (192\u00b1243 vs. 112\u00b1135 pg\/ml, p&amp;lt;0.001). The independent determinants of higher BNP levels were NYHA functional class and systolic pulmonary artery pressure in multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found increased plasma BNP levels in patients with rheumatic heart disease compared with healthy subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2004.04.018","type":"journal-article","created":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T15:44:01Z","timestamp":1091720641000},"page":"757-760","source":"Crossref","is-referenced-by-count":18,"title":["Plasma Brain Natriuretic Peptide Levels in Patients with Rheumatic Heart Disease"],"prefix":"10.1093","volume":"6","author":[{"given":"Zehra","family":"G\u00f6lba\u00fe\u00fd","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ankara T\u00fcrkiye Y\u00fcksek \u0130htisas Hospital , Attar sok. 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