{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:20:49Z","timestamp":1775686849211,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In patients with dilated cardiomyopathy (DCM), left bundle branch block (LBBB) is a common finding. The characteristic feature is an asynchronous septal wall motion and most frequently a delay of the lateral and\/or posterior wall segments. With the onset of cardiac resynchronization therapy, there is a focus on the specific pathophysiology of a LBBB. However, quantitative data on regional myocardial oxygen consumption (MVO2) and blood flow (MBF) are missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 31 patients with severe DCM and LBBB (ejection fraction 22.1\u00b17.1%) and 14 patients with mild to moderate DCM without LBBB (ejection fraction 46.7\u00b17.9%). Global and regional MVO2 as well as MBF were determined from a dynamic 11C-acetate positron emission tomography (PET) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Global MVO2 and MBF were lower in the DCM group with LBBB than in the control group (P&amp;lt;0.05). Regionally, the LBBB group revealed a higher (P&amp;lt;0.05) MVO2 and MBF in the lateral wall than in the other walls. The control group did not show significant differences between the myocardial walls and demonstrated a smaller variability of the parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DCM patients with LBBB exhibit a more heterogeneous distribution of MVO2 and MBF among the myocardial walls than DCM patients without LBBB. Due to the LBBB associated electromechanical alterations, the highest regional values of MVO2 and MBF are found in the lateral wall.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2004.07.003","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T14:44:17Z","timestamp":1098974657000},"page":"225-230","source":"Crossref","is-referenced-by-count":25,"title":["Global and Regional Myocardial Oxygen Consumption and Blood Flow in Severe Cardiomyopathy with Left Bundle Branch Block"],"prefix":"10.1093","volume":"7","author":[{"given":"Oliver","family":"Lindner","sequence":"first","affiliation":[{"name":"Institute of Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Heart and Diabetes Center North Rhine-Westphalia , Georgstr. 11, D-32545, Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlev","family":"Baller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annett","family":"Kammeier","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Heart and Diabetes Center North Rhine-Westphalia , Georgstr. 11, D-32545, Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wielepp","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Heart and Diabetes Center North Rhine-Westphalia , Georgstr. 11, D-32545, Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Holzinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Lamp","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Horstkotte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Burchert","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Heart and Diabetes Center North Rhine-Westphalia , Georgstr. 11, D-32545, Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"2026020203551546500_ejhf2004-07-003-bib-0001","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0002-9149(84)90320-5","article-title":"Factors influencing the one-year mortality of dilated cardiomyopathy","volume":"54","author":"Unverferth","year":"1984","journal-title":"Am. 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