{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:26:26Z","timestamp":1770060386347,"version":"3.49.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with refractory heart failure requiring inotropic support have a very poor prognosis. Cardiac resynchronisation therapy (CRT) offers symptomatic and possibly a survival benefit for patients with stable chronic heart failure (CHF) and a prolonged QRS, but its role in the management of end-stage heart failure requiring inotropic support has not been evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective observational study of patients undergoing CRT at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 10 patients who required inotropic support for refractory CHF and who underwent CRT while on intravenous inotropic agents. Patients had been in hospital for 30\u00b129 days and had received inotropic support for 11\u00b16 days prior to CRT. All patients were weaned from inotropic support (2\u00b12 days post-CRT) and all patients survived to hospital discharge (12\u00b113 days post-CRT). Furosemide dose fell from 160\u00b138 mg on admission to 108\u00b153 mg on discharge (p&amp;lt;0.01). Serum creatinine fell from 192\u00b134 \u03bcmol\/l prior to CRT to 160\u00b137 \u03bcmol\/l on discharge (p&amp;lt;0.05). Serum sodium was 131\u00b14 mmol\/l prior to CRT and remained low at 132\u00b15 mmol\/l on discharge. At short-term follow up (mean 47 days), all patients were alive; mean furosemide dose was 130\u00b153 mg (p=0.056 versus pre-CRT). Serum creatinine was 157\u00b136 \u03bcmol\/l and serum sodium had increased to 138\u00b16 mmol\/l (p&amp;lt;0.05 and p&amp;lt;0.01, respectively, versus pre-CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRT may offer a new therapeutic option for inotrope-supported CHF patients with a prolonged QRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2004.11.005","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T03:49:10Z","timestamp":1106970550000},"page":"215-217","source":"Crossref","is-referenced-by-count":43,"title":["Cardiac Resynchronisation Therapy: An Option for Inotrope-Supported Patients with End-Stage Heart Failure?"],"prefix":"10.1093","volume":"7","author":[{"given":"Peter J.","family":"Cowburn","sequence":"first","affiliation":[{"name":"Mount Sinai Hospital , 600 University Avenue, Suite 1609, Toronto, Ontario ,","place":["Canada, M5G 1X5"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshna","family":"Patel","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital , 600 University Avenue, Suite 1609, Toronto, Ontario ,","place":["Canada, M5G 1X5"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robynn E.","family":"Jolliffe","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital , 600 University Avenue, Suite 1609, Toronto, Ontario ,","place":["Canada, M5G 1X5"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Wald","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital , 600 University Avenue, Suite 1609, Toronto, Ontario ,","place":["Canada, M5G 1X5"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Parker","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital , 600 University Avenue, Suite 1609, Toronto, Ontario ,","place":["Canada, M5G 1X5"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"2026020203544974600_ejhf2004-11-005-bib-0001","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-term mechanical left ventricular assistance for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2026020203544974600_ejhf2004-11-005-bib-0002","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/01.sla.0000090447.73384.ad","article-title":"Left ventricular assist devices as permanent heart failure therapy: the price of progress","volume":"238","author":"Oz","year":"2003","journal-title":"Ann. Surg."},{"key":"2026020203544974600_ejhf2004-11-005-bib-0003","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N. Engl. J. 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Heart J."}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejheart.2004.11.005","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/7\/2\/215\/66637360\/eurjhf_7_2_215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/7\/2\/215\/66637360\/eurjhf_7_2_215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:54:54Z","timestamp":1770022494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/7\/2\/215\/8444984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,8]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,2,8]]},"published-print":{"date-parts":[[2005,3,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ejheart.2004.11.005","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,3]]},"published":{"date-parts":[[2005,2,8]]}}}