{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:17:32Z","timestamp":1776129452564,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with heart failure have an abnormally high ventilatory response to exercise associated with gas exchange defects and reduced arterial pCO2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We examined the possibility of lactic acidosis as the stimulus to this increased ventilation that abnormally depresses pCO2 during exercise in heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and results<\/jats:title>\n                    <jats:p>We studied 18 patients with chronic heart failure. We measured VE\/VCO2 slope during exercise, arterial blood gases and lactate concentrations during cardiopulmonary exercise testing (rest, peak exercise and one minute after the end of exercise). Neither VE\/VCO2 slope nor arterial pCO2 were related to arterial lactate concentrations at peak exercise (r=\u20130.16, p=0.65 and r=\u20130.15, p=0.6). During early recovery, patients with a high VE\/VCO2 slope had a particularly pronounced rise in arterial lactate and hydrogen ion concentrations (r=0.57, p&amp;lt;0.05 and r=0.84, p&amp;lt;0.0001) and yet their arterial pCO2 rose rather than fell (r=0.79, p&amp;lt;0.001). The rise in arterial pCO2 correlated with the increase in arterial hydrogen concentration (r=0.78, p&amp;lt;0.001) and with arterial pCO2 at peak exercise (r=\u20130.76, p&amp;lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In heart failure VE\/VCO2 slope and low arterial pCO2 at peak exercise are not related to the degree of systemic lactic acidosis. Lactic acidosis is therefore not a plausible mechanism of exercise induced hyperventilation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2004.12.005","type":"journal-article","created":{"date-parts":[[2005,4,9]],"date-time":"2005-04-09T07:57:04Z","timestamp":1113033424000},"page":"1105-1111","source":"Crossref","is-referenced-by-count":18,"title":["Exercise Hyperventilation in Chronic Heart Failure is Not Caused by Systemic Lactic Acidosis"],"prefix":"10.1093","volume":"7","author":[{"given":"Roland","family":"Wensel","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["UK"]},{"name":"Medizinische Klinik II, Klinikum der Universit\u00e4t Regensburg , Franz-Josef-Strau\u00df-Allee 11, 93042, Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrel P.","family":"Francis","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiota","family":"Georgiadou","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Scott","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Genth-Zotz","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["UK"]},{"name":"Medizinische Klinik II, Johannes Gutenberg Universit\u00e4t , Mainz ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["UK"]},{"name":"Universit\u00e4tsklinik (Charit\u00e9, Campus Virchow) der Humboldt-Universit\u00e4t zu , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sydney \u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo F.","family":"Piepoli","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,12,22]]},"reference":[{"key":"2026020203571625400_ejhf2004-12-005-bib-0001","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/01.CIR.65.6.1213","article-title":"Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure","volume":"65","author":"Weber","year":"1982","journal-title":"Circulation"},{"key":"2026020203571625400_ejhf2004-12-005-bib-0002","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1164\/arrd.1984.129.2P2.S63","article-title":"Ventilation and gas exchange during exercise in severe chronic heart failure","volume":"129","author":"Rubin","year":"1984","journal-title":"Am. 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