{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:42:18Z","timestamp":1789965738624,"version":"4.0.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac resynchronisation therapy (CRT) is a promising new treatment for patients with heart failure and cardiac dyssynchrony. The CARE-HF study is a morbidity\/mortality trial designed to provide conclusive evidence of the effects of CRT in patients with moderate to severe heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A description of the baseline characteristics of patients randomised in the CARE-HF trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>813 Patients with predominantly NYHA class III (94%) heart failure were randomised in 82 centres. Their mean age was 65 (interquartile range [IQR] 59 to 72) years, 34% were aged &amp;gt;70 years and 27% were women. Thirty-eight percent of the patients had ischaemic heart disease. Mean heart rate was adequately controlled at 70 (IQR 60 to 78) bpm consistent with the use of beta-blockers. Supine systolic blood pressure was low at 117 (IQR 105 to 130) mm Hg. Eighty-eight percent of patients had a QRS \u2265150 ms. Mean LV ejection fraction was 26% (IQR 22 to 29) and end-diastolic dimension was 7.2 (IQR 6.4 to 7.8) cm. Ninety-four percent of patients were receiving loop diuretics, 95% an ACE inhibitor or angiotensin receptor blocker (ARB), 72% a beta-blocker and 56% were taking spironolactone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The patients enrolled in CARE-HF had moderately severe heart failure and cardiac dysfunction with evidence of cardiac dyssynchrony. The population appears at high risk of events despite pharmacological therapy and therefore appropriate for a trial of CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2005.01.010","type":"journal-article","created":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T10:16:12Z","timestamp":1107857772000},"page":"205-214","source":"Crossref","is-referenced-by-count":67,"title":["Baseline Characteristics of Patients Recruited Into the CARE-HF Study"],"prefix":"10.1093","volume":"7","author":[{"given":"J.G.F.","family":"Cleland","sequence":"first","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Daubert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Freemantle","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gras","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kappenberger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Castle Hill Hospital , Castle Road, Cottingham"},{"name":"University of Hull , Kingston upon Hull ,","place":["UK, HU16 5JQ"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"2026020203545815100_ejhf2005-01-010-bib-0001","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0735-1097(03)00948-3","article-title":"Delivering the cumulative benefits of triple therapy for heart failure. 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