{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:34:03Z","timestamp":1786988043103,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T00:00:00Z","timestamp":1140393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In some patients suffering from dilated cardiomyopathy (DCM) magnetic resonance imaging (MRI) shows late gadolinium enhancement with variable distribution. Myocardial biopsies in DCM reveal a chronic myocardial inflammatory process in almost 50% and myocardial persistence of adenoviral or enteroviral genome in about 15% of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We prospectively investigated whether the pattern of late gadolinium enhancement correlates with myocardial biopsy findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>42 patients with DCM and 42 control subjects underwent contrast MRI. In the DCM group, endomyocardial biopsies were performed and evaluated for inflammation and viral genome.<\/jats:p>\n                    <jats:p>None of the control subjects showed late gadolinium enhancement whereas in 29 DCM patients (69%) gadolinium enhancement was detectable (p&amp;lt;0.001). 21 of the DCM patients (50%) showed midwall septal enhancement, 7 patients (17%) showed a patchy distribution of hyperenhancement and 1 patient (2%) showed enhancement typical for ischemic heart disease. In myocardial biopsy analysis, 2 patients (5%) showed persistence of viral genome, 18 patients (43%) showed inflammation and in 22 patients (52%) neither virus nor inflammation was detected. The pattern of late gadolinium enhancement and myocardial biopsy findings were not significantly correlated (p=0.854).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRI as a non-invasive technique cannot replace myocardial biopsy for the differential diagnosis of DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2005.06.001","type":"journal-article","created":{"date-parts":[[2005,8,20]],"date-time":"2005-08-20T07:18:50Z","timestamp":1124522330000},"page":"162-166","source":"Crossref","is-referenced-by-count":33,"title":["Myocardial Biopsy Findings and Gadolinium Enhanced Cardiovascular Magnetic Resonance in Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"8","author":[{"given":"Oliver","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II\u2014Cardiology, University of Ulm , Robert\u2014Koch\u2014Str. 8, 89081, Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Grebe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Cardiology, University of Ulm , Robert\u2014Koch\u2014Str. 8, 89081, Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Merkle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Cardiology, University of Ulm , Robert\u2014Koch\u2014Str. 8, 89081, Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Nusser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Cardiology, University of Ulm , Robert\u2014Koch\u2014Str. 8, 89081, Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kochs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Cardiology, University of Ulm , Robert\u2014Koch\u2014Str. 8, 89081, Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Bienek-Ziolkowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Cardiology, University of Ulm , Robert\u2014Koch\u2014Str. 8, 89081, Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinzenz","family":"Hombach","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Cardiology, University of Ulm , Robert\u2014Koch\u2014Str. 8, 89081, Ulm 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