{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:58:32Z","timestamp":1770062312528,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the role of brain natriuretic peptide (BNP) in predicting the progression of heart failure (HF) after cardiac resynchronization therapy (CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It has been shown that BNP predicts the prognosis and can guide the treatment of HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 50 consecutive patients (61\u00b110 years, 23 male) with HF (8 with ischaemic cardiomyopathy), NYHA class III, left bundle branch block, left ventricular ejection fraction (LVEF) \u226435% (mean 24\u00b16%) who underwent CRT. All patients were taking conventional HF therapy and were clinically stable. Plasma BNP levels were evaluated by two-site dual-monoclonal immunochemiluminescent assay before, and 1 month after CRT. The predictive value of BNP was assessed using univariate and multivariate regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up (mean 19\u00b112 months), HF progression was observed in 14 patients (11 were hospitalised and 3 died after worsening of HF). Multivariate analysis showed that BNP levels before (HR: 2.07; CI: 1.19\u20133.62; p=0.01) and 1 month after CRT (HR: 2.23; CI: 1.26\u20133.94; p=0.006) were significantly related to events. At 1 month, a BNP level &amp;gt;91.5 pg\/ml had 89% sensitivity, 59% specificity, and negative and positive predictive values of 96% and 33%, respectively, for HF progression after 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HF patients with high BNP values after 1 month of CRT have worse prognosis during follow-up. Therefore, in these patients other therapeutic options should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2005.10.013","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T15:16:15Z","timestamp":1141226175000},"page":"509-514","source":"Crossref","is-referenced-by-count":25,"title":["Prognostic Value of Brain Natriuretic Peptide in the Management of Patients Receiving Cardiac Resynchronization Therapy"],"prefix":"10.1093","volume":"8","author":[{"given":"Maria Vittoria","family":"Pitzalis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, The Brody School of Medicine, East Carolina University , 600 Moye Boulevard, 27834, Greenville, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Iacoviello","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bari \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Di Serio","sequence":"additional","affiliation":[{"name":"UO Patologia Clinica I-Policlinico , Bari ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Romito","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, \u201cSalvatore Maugeri\u201d Foundation , IRCCS Cassano ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Guida","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bari \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"De Tommasi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bari \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Luzzi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bari \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Anaclerio","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bari \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Varraso","sequence":"additional","affiliation":[{"name":"UO Patologia Clinica I-Policlinico , Bari ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Forleo","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bari \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pansini","sequence":"additional","affiliation":[{"name":"UO Patologia Clinica I-Policlinico , Bari ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,8,15]]},"reference":[{"key":"2026020203524406400_ejhf2005-10-013-bib-0001","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N Engl J Med"},{"key":"2026020203524406400_ejhf2005-10-013-bib-0002","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0735-1097(00)00995-5","article-title":"Is the prognosis of heart failure improving?","volume":"36","author":"Khand","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2026020203524406400_ejhf2005-10-013-bib-0003","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1056\/NEJM200103223441202","article-title":"Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators. 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