{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:23:16Z","timestamp":1791354196516,"version":"4.3.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The prevalence of conduction disturbances, particularly left bundle branch block (LBBB), is strongly correlated with age and with the presence of cardiovascular disease. LBBB has been reported to affect approximately 25% of the heart failure (HF) population and it is likely that the deleterious role of such conduction disorders in the progression to HF has been underestimated.<\/jats:p>\n                  <jats:p>The purpose of this article is to review the data from the literature indicating that LBBB may have a causative role, mediated through the resulting intra-ventricular asynchrony, in the deterioration of cardiac function and the development of cardiac remodelling and HF. It also aims to address the potential for future clinical therapies for this conduction disorder.<\/jats:p>","DOI":"10.1016\/j.ejheart.2006.04.011","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T10:56:15Z","timestamp":1154948175000},"page":"7-14","source":"Crossref","is-referenced-by-count":149,"title":["Left Bundle Branch Block as a Risk Factor for Progression to Heart Failure"],"prefix":"10.1093","volume":"9","author":[{"given":"Faiez","family":"Zannad","sequence":"first","affiliation":[{"name":"CIC-INSERM-CHU de Nancy, Hospital Jeanne d'Arc, Dommartin-l\u00e8s-Toul , BP 303 - 54201, Toul Cedex ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Huvelle","sequence":"additional","affiliation":[{"name":"Guidant CRM Clinical Research Department , Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[{"name":"Department of cardiology, Stavanger University Hospital , Stavanger ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stellbrink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital , RWTH, Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet Heart Centre , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Cazeau","sequence":"additional","affiliation":[{"name":"Department of Cardiology , InParys, Saint-Cloud ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ritter","sequence":"additional","affiliation":[{"name":"Department of Cardiology , InParys, Saint-Cloud ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo Pietro","family":"Maggioni","sequence":"additional","affiliation":[{"name":"ANMCO Research Centre , Florence ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Ferrara , Ferrara ,","place":["Italy"]},{"name":"Cardiovascular Research Centre, Salvatore Maugeri Foundation, IRCCS , Gussago ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lechat","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department , Piti\u00e9-Salp\u00e9tri\u00e8re Hospital, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,1,14]]},"reference":[{"key":"2026020203452999000_ejhf2006-04-011-bib-0001","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1067\/mhj.2002.121264","article-title":"Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: a report from the Italian network on congestive heart failure","volume":"143","author":"Baldasseroni","year":"2002","journal-title":"Am Heart J"},{"key":"2026020203452999000_ejhf2006-04-011-bib-0002","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.98.22.2494","article-title":"Bundle-branch block in a general male population: the study of men born 1913","volume":"98","author":"Eriksson","year":"1998","journal-title":"Circulation"},{"key":"2026020203452999000_ejhf2006-04-011-bib-0003","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/01.CIR.79.4.845","article-title":"Functional abnormalities in isolated left bundle branch block. 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