{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:59:58Z","timestamp":1770065998665,"version":"3.49.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the European Society of Cardiology heart failure meeting held in June 2006. All reports should be considered as preliminary data, as analyses may change in the final publication.<\/jats:p>\n                  <jats:p>In a sub-group analysis of the TNT study, intensive treatment with high-dose atorvastatin significantly reduced hospitalisations for heart failure in patients with stable coronary heart disease, compared with low-dose atorvastatin; this benefit was most evident in patients with a history of heart failure at baseline. In a combined analysis of two studies of darbepoetin alfa, which included 475 patients, treatment increased and maintained haemoglobin levels and produced non-significant improvements in symptoms and morbidity in anaemic heart failure patients compared to placebo. In the FERRIC-HF study (n=35), intravenous iron sucrose therapy improved exercise capacity and symptom status in iron-deficient heart failure patients. In a combined analysis of two studies (n=186), the adenosine A1 receptor antagonist KW-3902 showed diuretic properties and appeared to enhance response to loop diuretics in heart failure patients hospitalised with fluid overload.<\/jats:p>","DOI":"10.1016\/j.ejheart.2006.07.003","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T17:44:58Z","timestamp":1154540698000},"page":"547-549","source":"Crossref","is-referenced-by-count":25,"title":["Clinical Trials Update from the European Society of Cardiology Heart Failure Meeting: TNT subgroup Analysis, Darbepoetin Alfa, FERRIC-HF and KW-3902"],"prefix":"10.1093","volume":"8","author":[{"given":"Alison P.","family":"Coletta","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU15 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lwin","family":"Tin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU15 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Huan","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU15 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU15 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU15 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,8,15]]},"reference":[{"key":"2026020203525045800_ejhf2006-07-003-bib-0001","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.jacc.2003.07.016","article-title":"The relationship between cholesterol and survival in patients with chronic heart failure","volume":"42","author":"Rauchhaus","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2026020203525045800_ejhf2006-07-003-bib-0002","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa050461","article-title":"Treating to New Targets (TNT) Investigators. Intensive lipid lowering with atorvastatin in patients with stable coronary disease","volume":"352","author":"LaRosa","year":"2005","journal-title":"N Eng J Med"},{"key":"2026020203525045800_ejhf2006-07-003-bib-0003","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.ejheart.2005.09.005","article-title":"CORONA study group. A statin in the treatment of heart failure? Controlled rosuvastatin multinational study in heart failure (CORONA): study design and baseline characteristics","volume":"7","author":"Kjekshus","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"2026020203525045800_ejhf2006-07-003-bib-0004","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ejheart.2004.03.001","article-title":"GISSI-HF investigators. Rationale and design of the GISSI heart failure trial: a large trial to assess the effects of n\u22123 polyunsaturated fatty acids and rosuvastatin in symptomatic congestive heart failure","volume":"6","author":"Tavazzi","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"2026020203525045800_ejhf2006-07-003-bib-0005","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ejheart.2006.04.005","article-title":"Clinical trials update from the American College of Cardiology: darbepoetin alfa, ASTEROID, UNIVERSE, paediatric carvedilol, UNLOAD and ICELAND","volume":"8","author":"Cleland","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"2026020203525045800_ejhf2006-07-003-bib-0006","first-page":"187","article-title":"Haemodilution is the primary cause of mild anaemia in heart failure","volume":"5","author":"Tin","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"2026020203525045800_ejhf2006-07-003-bib-0007","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.jacc.2005.11.084","article-title":"Renal impairment and outcomes in heart failure: systematic review and meta-analysis","volume":"47","author":"Smith","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2026020203525045800_ejhf2006-07-003-bib-0008","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/eurheartj\/ehi696","article-title":"Incidence of renal dysfunction over 6 months in patients with chronic heart failure due to left ventricular systolic dysfunction: contributing factors and relationship to prognosis","volume":"27","author":"de Silva","year":"2006","journal-title":"Eur Heart J"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejheart.2006.07.003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/8\/5\/547\/66616993\/eurjhf_8_5_547.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/8\/5\/547\/66616993\/eurjhf_8_5_547.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:52:58Z","timestamp":1770022378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/8\/5\/547\/8443891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,1]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2006,8,15]]},"published-print":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ejheart.2006.07.003","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,8]]},"published":{"date-parts":[[2006,8,1]]}}}