{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T02:00:37Z","timestamp":1775872837100,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2007,4,15]],"date-time":"2007-04-15T00:00:00Z","timestamp":1176595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The early diagnosis and treatment of heart failure in \u03b2-thalassaemic patients is related to survival. Iron alone or in combination with other factors causes diastolic dysfunction, which usually precedes systolic dysfunction. NT-proBNP is a sensitive biomarker of ventricular dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate NT-proBNP in non heart failure \u03b2-thalassaemic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-two \u03b2-thalassaemia major patients (mean age: 27.2\u00b112.5 years) with normal LV systolic function, underwent NT-proBNP measurement and a thorough Doppler-echocardiographic and pulsed tissue-Doppler study, 4 days following blood transfusion. Fifty-two age matched healthy controls were also studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NT-proBNP and E\/E\u2032 ratio were increased in thalassaemic patients compared with controls [(469\u00b1171 vs 262\u00b151 pmol\/l, p&amp;lt;0.001) and (10.8\u00b14.0 vs 6.6\u00b11.1, p&amp;lt;0.001)] and were well correlated (r: 0.54, p&amp;lt;0.01). Although NT-proBNP levels were increased in patients with higher E\/E\u2032 ratios (E\/E\u2032 &amp;lt;8: 354\u00b1119, 8\u201315: 516\u00b1177, &amp;gt;15: 565\u00b1114 pmol\/l, ANOVA p: 0.002) this increase only became statistically significant in the 3rd decade of life, while E\/E\u2032 ratio increased in the 4th decade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NT-proBNP increases in \u03b2-thalassaemia major patients and is related to age and LV diastolic dysfunction. NT-proBNP appears to be an early biomarker of LV diastolic dysfunction, compared with the conventional Echo-Doppler indexes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2006.11.004","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T09:42:01Z","timestamp":1172137321000},"page":"531-536","source":"Crossref","is-referenced-by-count":36,"title":["NT-proBNP Levels and Diastolic Dysfunction in \u03b2-Thalassaemia Major Patients"],"prefix":"10.1093","volume":"9","author":[{"given":"Dimitrios Th.","family":"Kremastinos","sequence":"first","affiliation":[{"name":"2nd University Department of Cardiology, Attikon General Hospital , Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios P.","family":"Tsiapras","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Onassis Cardiac Surgery Center , Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna G.","family":"Kostopoulou","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Onassis Cardiac Surgery Center , Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eftihia S.","family":"Hamodraka","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Onassis Cardiac Surgery Center , Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antigoni S.","family":"Chaidaroglou","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Onassis Cardiac Surgery Center , Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia D.","family":"Kapsali","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Onassis Cardiac Surgery Center , Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,4,15]]},"reference":[{"key":"2026020203472624500_ejhf2006-11-004-bib-0001","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1161\/01.CIR.30.5.698","article-title":"Late cardiac complications of chronic, severe, refractory anemia with hemochromatosis","volume":"30","author":"Engle","year":"1964","journal-title":"Circulation"},{"key":"2026020203472624500_ejhf2006-11-004-bib-0002","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM199907083410207","article-title":"The beta-thalassemias","volume":"341","author":"Olivieri","year":"1999","journal-title":"N Engl J Med"},{"key":"2026020203472624500_ejhf2006-11-004-bib-0003","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/01.CIR.91.1.66","article-title":"Myocarditis in beta-thalassemia major. 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