{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:18:36Z","timestamp":1773343116626,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6-7","license":[{"start":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T00:00:00Z","timestamp":1178841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The oxygen uptake efficiency slope (OUES) is a new exercise parameter that provides prognostic power in patients with CHF. Little is known about the effects of exercise training (ET) on OUES.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the response of OUES to 6 months of ET in CHF patients and compare its evolution to that of other exercise variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>35 patients with CHF (NYHA II\u2013III, age 54\u00b19y, LVEF 31\u00b110%) performed 3 maximal exercise tests, i.e. at the start, middle and end of a 6 month ET program. OUES, PeakVO2, ventilatory anaerobic threshold (VAT) and slope VE\/VCO2 were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>OUES, peakVO2, VAT, slope VE\/VCO2, peak Watt, 6MWT and NYHA-class improved during the first part of the ET period (p&amp;lt;0.05). Only VAT, peak Watt and 6MWT continued to improve during the second part of the ET period (p&amp;gt;0.05) Improvements in OUES correlated better with improvements in peakVO2 (r=0.77, p&amp;lt;0.001), than changes in other prognostic variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>OUES improves significantly after 6 months of ET. Changes in peakVO2 correlate best with changes in OUES. OUES is sensitive to ET and can be used to evaluate the progression of exercise capacity in CHF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2007.01.007","type":"journal-article","created":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T07:05:12Z","timestamp":1173423912000},"page":"625-629","source":"Crossref","is-referenced-by-count":69,"title":["Response of the Oxygen Uptake Efficiency Slope to Exercise Training in Patients with Chronic Heart Failure"],"prefix":"10.1093","volume":"9","author":[{"given":"Christophe","family":"Van Laethem","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Artevelde Institute of Higher Education , Ghent ,","place":["Belgium"]},{"name":"Cardiovascular Center, Onze Lieve Vrouw Hospital , Aalst ,","place":["Belgium"]},{"name":"Cardiac Rehabilitation Unit, University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"Van De Veire","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"De Backer","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Unit, University Hospital , Ghent ,","place":["Belgium"]},{"name":"Department of Cardiology, University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salhi","family":"Bihija","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Unit, University Hospital , Ghent ,","place":["Belgium"]},{"name":"Department of Rehabilitation Sciences and Physiotherapy, University Ghent \u00a0","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Seghers","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Unit, University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Cambier","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, University Ghent \u00a0","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Vanderheyden","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Onze Lieve Vrouw Hospital , Aalst ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"De Sutter","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Unit, University Hospital , Ghent ,","place":["Belgium"]},{"name":"Department of Cardiology, University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,5,11]]},"reference":[{"key":"2026020203474913900_ejhf2007-01-007-bib-0001","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/01.CIR.83.3.778","article-title":"Value of peak oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure","volume":"83","author":"Mancini","year":"1991","journal-title":"Circulation"},{"key":"2026020203474913900_ejhf2007-01-007-bib-0002","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1161\/01.CIR.0000041428.99427.06","article-title":"Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death","volume":"106","author":"Gitt","year":"2002","journal-title":"Circulation"},{"key":"2026020203474913900_ejhf2007-01-007-bib-0003","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1136\/hrt.78.6.572","article-title":"Comparison of the long-term prognostic value of peak exercise oxygen pulse and peak oxygen uptake in patients with chronic heart failure","volume":"78","author":"Cohen-Solal","year":"1997","journal-title":"Heart"},{"key":"2026020203474913900_ejhf2007-01-007-bib-0004","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1067\/mhj.2002.120772","article-title":"Ventilatory response to exercise improves risk stratification in patients with chronic heart failure and intermediate functional capacity","volume":"143","author":"Corra","year":"2002","journal-title":"Am Heart J"},{"key":"2026020203474913900_ejhf2007-01-007-bib-0005","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/01.CIR.103.7.967","article-title":"Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance. 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