{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:40:00Z","timestamp":1788831600313,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The identification of valuable markers of sudden cardiac death (SCD) in patients with established HF remains a challenge. We sought to assess the value of clinical, echocardiographic and biochemical variables to predict SCD in a consecutive cohort of patients with heart failure (HF) due to systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of 494 patients with established HF had baseline echocardiographic and NT-proBNP measurements and were followed for 942\u00b1323 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty patients suffered SCD. Independent predictors of SCD were indexed LA size &amp;gt;26 mm\/m2 (HR 2.8; 95% CI 1.5\u20135.0; p=0.0007), NT-proBNP &amp;gt;908 ng\/L (HR 3.1; 95% CI 1.5\u20136.7; p=0.003), history of myocardial infarction (HR 2.3; 95% CI 1.3\u20134.1; p=0.007), peripheral oedema (HR 2.1; 95% CI 1.1\u20133.9; p=0.02), and diabetes mellitus (HR 1.9; 95% CI 1.1\u20133.3; p=0.03). NYHA functional class, left ventricular ejection fraction and glomerular filtration rate were not independent predictors of SCD in this cohort. Notably, the combination of both LA size &amp;gt;26 mm\/m2 and NT-proBNP &amp;gt;908 ng\/L increased the risk of SCD (HR 4.3; 95% CI 2.5\u20137.6; p&amp;lt;0.0001). At 36 months, risk of SCD in patients with indexed LA size \u226426 mm\/m2 and NT-proBNP \u2264908 ng\/L was 3%, while in patients with indexed LA size &amp;gt;26 mm\/m2 and NT-proBNP &amp;gt;908 ng\/L reached 25% (p&amp;lt;0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among HF patients, indexed LA size and NT-proBNP levels are more useful to stratify risk of SCD than other clinical, echocardiographic or biochemical variables. The combination of these two parameters should be considered for predicting SCD in patients with HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2007.05.001","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T08:27:18Z","timestamp":1181809638000},"page":"802-807","source":"Crossref","is-referenced-by-count":41,"title":["Left Atrial Enlargement and NT-proBNP as Predictors of Sudden Cardiac Death in Patients with Heart Failure"],"prefix":"10.1093","volume":"9","author":[{"given":"Antoni","family":"Bayes-Genis","sequence":"first","affiliation":[{"name":"Cardiology Service, Hospital Santa Creu i Sant Pau-ICCC , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital de Valme , Seville ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Puig","sequence":"additional","affiliation":[{"name":"Epidemiology Service, Hospital Santa Creu i Sant Pau , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fernandez-Palomeque","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Son Dureta , Palma de Mallorca ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Fabregat","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Santa Creu i Sant Pau-ICCC , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Bardaj\u00ed","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Joan XXIII , Tarragona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Pascual-Figal","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Virgen Arrixaca , Murcia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Ordo\u00f1ez-Llanos","sequence":"additional","affiliation":[{"name":"Biochemistry Service, Hospital Santa Creu i Sant Pau , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Valdes","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Virgen Arrixaca , Murcia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Gabarr\u00fas","sequence":"additional","affiliation":[{"name":"Epidemiology Service, Hospital Santa Creu i Sant Pau , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pavon","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital de Valme , Seville ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Pastor","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital de Valme , Seville ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Ramon Gonzalez","family":"Juanatey","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Universitario Santiago de Compostela \u00a0","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Almendral","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Gregorio Mara\u00f1on , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Fiol","sequence":"additional","affiliation":[{"name":"Biochemistry Service, Hospital Santa Creu i Sant Pau , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Nieto","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Insular, Las Palmas de Gran Canaria \u00a0","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Macaya","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Cl\u00ednico , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cinca","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Santa Creu i Sant Pau-ICCC , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni Bayes","family":"de 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