{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:52:55Z","timestamp":1792644775859,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We examined the relation of maximal in-hospital diuretic dose to weight loss, changes in renal function, and mortality in hospitalised heart failure (HF) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In ESCAPE, 395 patients received diuretics in-hospital. Weight was measured at baseline, discharge, and every other day before discharge. Weight loss was defined as the difference between baseline and last in-hospital weight. Mortality was assessed using a log-logistic model with non-zero background.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median weight loss: 2.8kg (0.7, 6.1); mean: 3.7kg (22% of values &amp;lt;0). Weight loss and maximum in-hospital dose were correlated (p=0.0007). Baseline weight, length of stay, and baseline brain natriuretic peptide were significant predictors of weight loss. After adjusting for these, dose was not a significant predictor of weight loss. A strong relation between dose and mortality was seen (p=0.003), especially at &amp;gt;300mg\/day. Dose remained a significant predictor of mortality after adjusting for baseline variables that significantly predicted mortality. Correlation between maximal dose and creatinine level change was not significant (r=0.043; p=0.412)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High diuretic doses during HF hospitalisation are associated with increased mortality and poor 6-month outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2007.07.011","type":"journal-article","created":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T10:57:19Z","timestamp":1188212239000},"page":"1064-1069","source":"Crossref","is-referenced-by-count":370,"title":["Relation between Dose of Loop Diuretics and Outcomes in a Heart Failure Population: Results of the ESCAPE Trial"],"prefix":"10.1093","volume":"9","author":[{"given":"Vic","family":"Hasselblad","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute, Duke University Medical Center , Durham, NC ,","place":["United 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