{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:02:10Z","timestamp":1770058930745,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess plasma B-type natriuretic peptide (BNP) levels in patients with univentricular hearts late after volume unloading by total cavopulmonary connection (TCPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma BNP was measured by sandwich immunoassay in 67 patients after a modified Fontan procedure. BNP levels were compared with age and sex-specific normal values, clinical and echocardiographic data, and results of exercise testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BNP had a wide range of 5\u2013290 pg\/ml, but was normal in 81% of patients, and median BNP was only 13pg\/ml. There was no difference between males and females, between patients with left or right ventricular morphology, and no correlation was found between BNP and age, post-operative follow-up period, maximum exercise capability, peak oxygen uptake, or blood oxygen saturation. New York Heart Association class I patients had lower BNP than class II patients (p=0.04). Plasma BNP concentration was positively correlated to the number of specific sequelae (r=0.59, p&amp;lt;0.001), and to severity of atrioventricular regurgitation (r=0.38, p=0.002). 5\/13 patients with elevated BNP died during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BNP plasma concentration was normal in the majority of patients up to 15 years after TCPC. Elevated and increasing BNP levels were associated with increased morbidity and late mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2007.11.001","type":"journal-article","created":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T07:55:52Z","timestamp":1199692552000},"page":"60-62","source":"Crossref","is-referenced-by-count":48,"title":["B-Type Natriuretic Peptide Levels in Patients with Functionally Univentricular Hearts After Total Cavopulmonary Connection"],"prefix":"10.1093","volume":"10","author":[{"given":"Andreas M.E.","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Paediatric Cardiology, University of Erlangen-N\u00fcrnberg \u00a0","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zink","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, University of Erlangen-N\u00fcrnberg 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