{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:05:59Z","timestamp":1791155159994,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tissue kallikrein (TK) is a major kinin-releasing enzyme present in arteries. TK is involved in cardioprotection in the setting of acute myocardial ischaemia but its role in post-ischaemic heart failure (HF), a major cause of delayed mortality after myocardial infarction (MI), is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine whether TK deficiency in the mouse influences survival and cardiac remodelling after MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MI was induced in 10 week-old male TK-deficient mice and wild-type littermates. Survival was assessed up to 14 months. Cardiac morphological and functional parameters were serially measured by echocardiography. In another experiment, myocardial capillary density and NOS content were evaluated at 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Infarct size was similar in both genotypes. MI resulted in severe cardiac dysfunction. Up to 12 months after MI, TK\u2212\/\u2212 mice displayed an increased mortality rate (P &amp;lt; 0.05, relative risk of death = 3.41) and aggravation of left ventricular hypertrophy and dilatation by comparison with TK+\/+ (+18% and +27% respectively, both P &amp;lt; 0.05). NOS1 and NOS3 were abnormally regulated in the heart of TK+\/+ mice after MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TK exerts a protective role in HF in mice. Coronary effects are probably involved. As partial genetic deficiency in TK activity occurs in humans, TK-deficient subjects may be at increased risk of mortality in HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2008.02.002","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T11:24:33Z","timestamp":1205580273000},"page":"343-351","source":"Crossref","is-referenced-by-count":24,"title":["Tissue kallikrein Deficiency Aggravates Cardiac Remodelling and Decreases Survival after Myocardial Infarction in Mice"],"prefix":"10.1093","volume":"10","author":[{"given":"Sandrine","family":"Pons","sequence":"first","affiliation":[{"name":"INSERM U 652\/872, CRC, IFR 58 , Paris, F-75006 ,","place":["France"]},{"name":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre , F-94276 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Griol-Charhbili","sequence":"additional","affiliation":[{"name":"INSERM U 652\/872, CRC, IFR 58 , Paris, F-75006 ,","place":["France"]},{"name":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre , F-94276 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Heymes","sequence":"additional","affiliation":[{"name":"INSERM U689, IFR 139 , Paris, F-75011 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fornes","sequence":"additional","affiliation":[{"name":"INSERM U 652\/872, CRC, IFR 58 , Paris, F-75006 ,","place":["France"]},{"name":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre , F-94276 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Heudes","sequence":"additional","affiliation":[{"name":"INSERM U 652\/872, CRC, IFR 58 , Paris, F-75006 ,","place":["France"]},{"name":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre , F-94276 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hagege","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Descartes , Paris, F-75006 ,","place":["France"]},{"name":"INSERM U633, H\u00f4pital Broussais , Paris, F-75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Loyer","sequence":"additional","affiliation":[{"name":"INSERM U689, IFR 139 , Paris, F-75011 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Meneton","sequence":"additional","affiliation":[{"name":"INSERM U 652\/872, CRC, IFR 58 , Paris, F-75006 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Giudicelli","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre , F-94276 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane-Lise","family":"Samuel","sequence":"additional","affiliation":[{"name":"INSERM U689, IFR 139 , Paris, F-75011 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Alhenc-Gelas","sequence":"additional","affiliation":[{"name":"INSERM U 652\/872, CRC, IFR 58 , Paris, F-75006 ,","place":["France"]},{"name":"Universit\u00e9 Paris-Descartes , Paris, F-75006 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Richer","sequence":"additional","affiliation":[{"name":"INSERM U 652\/872, CRC, IFR 58 , Paris, F-75006 ,","place":["France"]},{"name":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre , F-94276 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2026020203433543200_ejhf2008-02-002-bib-0001","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199209033271001","article-title":"Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators","volume":"327","author":"Pfeffer","year":"1992","journal-title":"N Engl J Med"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0002","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1096\/fj.04-3508fje","article-title":"Role of tissue kallikrein in the cardioprotective effects of ischemic and pharmacological preconditioning in myocardial ischemia","volume":"19","author":"Griol-Charhbili","year":"2005","journal-title":"FASEB J"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0003","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1096\/fj.99-1011fje","article-title":"Increased kallikrein expression protects against cardiac ischemia","volume":"14","author":"Pinto","year":"2000","journal-title":"FASEB J"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0004","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cardiores.2003.10.018","article-title":"The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction","volume":"61","author":"Tschope","year":"2004","journal-title":"Cardiovasc Res"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0005","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1161\/01.CIR.95.7.1910","article-title":"Differential effects of kinins on cardiomyocyte hypertrophy and interstitial collagen matrix in the surviving myocardium after myocardial infarction in the rat","volume":"95","author":"Wollert","year":"1997","journal-title":"Circulation"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.HYP.0000153322.04859.81","article-title":"Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction","volume":"45","author":"Xu","year":"2005","journal-title":"Hypertension"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0007","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/hh1001.090759","article-title":"Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B(2) kinin receptor gene knockout mice","volume":"88","author":"Yang","year":"2001","journal-title":"Circ Res"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0008","doi-asserted-by":"crossref","first-page":"H507","DOI":"10.1152\/ajpheart.2000.278.2.H507","article-title":"Role of kinins in chronic heart failure and in the therapeutic effect of ACE inhibitors in kininogen-deficient rats","volume":"278","author":"Liu","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0009","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1073\/pnas.051619598","article-title":"Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice","volume":"98","author":"Meneton","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0010","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/01.RES.88.6.593","article-title":"Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice","volume":"88","author":"Bergaya","year":"2001","journal-title":"Circ Res"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0011","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1161\/01.HYP.23.6.919","article-title":"A local kallikrein-kinin system is present in rat hearts","volume":"23","author":"Nolly","year":"1994","journal-title":"Hypertension"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0012","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1172\/JCI200523669","article-title":"Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans","volume":"115","author":"Azizi","year":"2005","journal-title":"J Clin Invest"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0013","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/01.HYP.0000021747.43346.95","article-title":"Cardiovascular phenotypes of kinin B2 receptor- and tissue kallikrein-deficient mice","volume":"40","author":"Trabold","year":"2002","journal-title":"Hypertension"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0014","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1440-1681.2003.03784.x","article-title":"Survival, haemodynamics and cardiac remodelling follow up in mice after myocardial infarction","volume":"30","author":"Pons","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0015","first-page":"H1812","article-title":"Ventricular remodeling in a mouse model of myocardial infarction","volume":"274","author":"Patten","year":"1998","journal-title":"Am J Physiol"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0016","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0017","first-page":"147","article-title":"Long-term treatment with trandolapril opposes cardiac remodeling and prolongs survival after myocardial infarction in rats","volume":"20","author":"Richer","year":"1992","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0018","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(04)16048-0","article-title":"Increased neuronal nitric oxide synthase-derived NO production in the failing human heart","volume":"363","author":"Damy","year":"2004","journal-title":"Lancet"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0019","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0003-9969(88)90117-3","article-title":"The assay of glandular kallikrein and prekallikrein in human mixed saliva","volume":"33","author":"Jenzano","year":"1988","journal-title":"Arch Oral Biol"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0020","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/cvr\/24.11.946","article-title":"Urinary cyclic guanosine monophosphate as an indicator of experimental congestive heart failure in rats","volume":"24","author":"Michel","year":"1990","journal-title":"Cardiovasc Res"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0021","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1210\/endo-90-2-422","article-title":"Measurement of renin activity, concentration and substrate in rat plasma by radioimmunoassay of angiotensin I","volume":"90","author":"Menard","year":"1972","journal-title":"Endocrinology"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0022","first-page":"690","article-title":"Chi-square tests with one degree of freedom: extension of the Mantel-Haenszel procedure","volume":"58","author":"Mantel","year":"1963","journal-title":"J Am Stat Assoc"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0023","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0008-6363(99)00017-6","article-title":"Electrophysiological remodeling in hypertrophy and heart failure","volume":"42","author":"Tomaselli","year":"1999","journal-title":"Cardiovasc Res"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0024","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.76.1.44","article-title":"Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction","volume":"76","author":"White","year":"1987","journal-title":"Circulation"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(98)09374-X","article-title":"Effect of ACE inhibitor trandolapril on life expectancy of patients with reduced left-ventricular function after acute myocardial infarction. TRACE Study Group. Trandolapril Cardiac Evaluation","volume":"354","author":"Torp-Pedersen","year":"1999","journal-title":"Lancet"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0026","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.94.1.44","article-title":"Regulation of nitric oxide production in human coronary microvessels and the contribution of local kinin formation","volume":"94","author":"Kichuk","year":"1996","journal-title":"Circulation"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0027","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/01.HYP.0000036035.41122.99","article-title":"Kallikrein gene delivery improves cardiac reserve and attenuates remodeling after myocardial infarction","volume":"40","author":"Agata","year":"2002","journal-title":"Hypertension"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0028","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/hc3601.094298","article-title":"Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice","volume":"104","author":"Scherrer-Crosbie","year":"2001","journal-title":"Circulation"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0029","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1161\/CIRCULATIONAHA.105.539437","article-title":"nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction","volume":"112","author":"Dawson","year":"2005","journal-title":"Circulation"},{"key":"2026020203433543200_ejhf2008-02-002-bib-0030","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1681\/ASN.V134968","article-title":"Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity","volume":"13","author":"Slim","year":"2002","journal-title":"J Am Soc Nephrol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejheart.2008.02.002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/10\/4\/343\/66563947\/eurjhf_10_4_343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/10\/4\/343\/66563947\/eurjhf_10_4_343.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:43:48Z","timestamp":1770021828000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/10\/4\/343\/8439950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,1,13]]},"published-print":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ejheart.2008.02.002","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,4]]},"published":{"date-parts":[[2008,4,1]]}}}