{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:42:36Z","timestamp":1790419356645,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The effects of the left ventricular (LV) pacing site on the clinical results of resynchronization therapy (CRT) are not well characterized. The aim of this study was to define the effect of LV lead location on clinical response and LV remodelling, and to identify predictors of failure to implant the LV lead in a lateral location.<\/jats:p>\n                  <jats:p>One hundred and seventy two consecutive patients were evaluated at baseline and 6 months after CRT. In 128 patients, the LV lead was implanted in the lateral region (Group 1), while 44 received an anterior implant due to anatomical or electrical factors (Group 2). Group 1 was associated with a significantly better functional outcome assessed both by NYHA class (p &amp;lt; 0.001) and by the six-minute-walk test (p = 0.01) compared with group 2. LV ejection fraction and volumes, and inter- and intraventricular dyssynchrony only improved significantly (p &amp;lt; 0.01) in group 1. The only independent predictor of a failed lateral implant was the presence of ischaemic cardiomyopathy (OR 3.29, 95% CI 2.2\u201313.7; p = 0.02).<\/jats:p>\n                  <jats:p>In conclusion, a lateral lead location results in a better functional outcome and greater reverse LV remodelling compared with anterior locations. The presence of ischaemic cardiomyopathy is a risk factor for a failed lateral LV implant.<\/jats:p>","DOI":"10.1016\/j.ejheart.2008.02.019","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T12:39:46Z","timestamp":1207658386000},"page":"421-427","source":"Crossref","is-referenced-by-count":31,"title":["Left Ventricular Pacing Site in Cardiac Resynchronization Therapy: Clinical Follow-Up and Predictors of Failed Lateral Implant"],"prefix":"10.1093","volume":"10","author":[{"given":"Alfonso","family":"Mac\u00edas","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, University Clinic, School of Medicine, University of Navarra , Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Jos\u00e9","family":"Gavira","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, University Clinic, School of Medicine, University of Navarra , Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, University Clinic, School of Medicine, University of Navarra , Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Alegr\u00eda","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, University Clinic, School of Medicine, University of Navarra , Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Garc\u00eda-Bolao","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, University Clinic, School of Medicine, University of Navarra , Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2026020203432385200_ejhf2008-02-019-bib-0001","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/01.hco.0000198983.93755.99","article-title":"The problem of non-response to cardiac resynchronization therapy","volume":"21","author":"Birnie","year":"2006","journal-title":"Curr Opin Cardiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0002","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.amjcard.2005.02.009","article-title":"SCARS Investigators. Predictors of lack of response to resynchronization therapy","volume":"95","author":"Diaz-Infante","year":"2005","journal-title":"Am J Cardiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/eurheartj\/ehl379","article-title":"Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients","volume":"28","author":"Ypenburg","year":"2007","journal-title":"Eur Heart J"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0004","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.amjcard.2004.08.028","article-title":"Comparison of response to cardiac resynchronization therapy in patients with sinus rhythm versus chronic atrial fibrillation","volume":"94","author":"Molhoek","year":"2004","journal-title":"Am J Cardiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0005","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.amjcard.2005.04.045","article-title":"Radiographic left ventricular-right ventricular interlead distance predicts the acute hemodynamic response to cardiac resynchronization therapy","volume":"96","author":"Heist","year":"2005","journal-title":"Am J Cardiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0006","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1046\/j.1540-8167.2004.04089.x","article-title":"Impact of coronary sinus lead position on biventricular pacing: mortality and echocardiographic evaluation during long-term follow-up","volume":"15","author":"Rossillo","year":"2004","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0007","doi-asserted-by":"crossref","first-page":"136D","DOI":"10.1016\/S0002-9149(98)01015-7","article-title":"Transvenous biventricular pacing for heart failure: can the obstacles be overcome?","volume":"83","author":"Auricchio","year":"1999","journal-title":"Am J Cardiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0008","first-page":"2348","article-title":"Safety of transvenous cardiac resynchronization system implantation in patients with chronic heart failure combined results of over 2000 patients from a multicenter study program","volume":"46","author":"Leon","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0009","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.amjcard.2005.12.054","article-title":"Tissue synchronization imaging and optimal left ventricular pacing site in cardiac resynchronization therapy","volume":"97","author":"Murphy","year":"2006","journal-title":"Am J Cardiol"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0010","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1161\/CIRCULATIONAHA.106.643718","article-title":"Three-dimensional mapping of optimal left ventricular pacing site for cardiac resynchronization","volume":"115","author":"Helm","year":"2007","journal-title":"Circulation"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0011","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1161\/01.CIR.96.10.3273","article-title":"Evaluation of different ventricular pacing sites in patients with severe heart failure: results of an acute hemodynamic study","volume":"96","author":"Blanc","year":"1997","journal-title":"Circulation"},{"key":"2026020203432385200_ejhf2008-02-019-bib-0012","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1161\/hc5001.102229","article-title":"Pacing Therapy for Chronic Heart Failure II Study Group. 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