{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:45:58Z","timestamp":1770061558448,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biventricular (BiV) pacing is an established therapy for heart failure in ischaemic and dilated cardiomyopathy. Its effects in end-stage hypertrophic cardiomyopathy (HCM) are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the potential benefits of BiV pacing in patients with symptomatic end-stage HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty patients with non-obstructive HCM (12 male, mean age 57\u00b113 years), left bundle branch block and symptoms of heart failure refractory to medical therapy underwent implantation of a BiV device. NYHA class, echocardiographic parameters and exercise capacity were assessed before and after implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At a mean follow-up of 13\u00b16 months, an improvement of at least one NYHA class was reported in 8 (40%) patients. A clinical response was associated with an increase in ejection fraction (from 41\u00b114% to 50\u00b112%, p=0.009), and reductions in left ventricular end-diastolic diameter (from 57\u00b16 mm to 52\u00b17 mm, p=0.031) and left atrial diameter (from 65\u00b18 mm to 57\u00b16 mm, p=0.005). Percentage predicted peak oxygen consumption was unchanged in responders but significantly declined in non-responders (p=0.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BiV pacing improved heart failure symptoms in a significant proportion of patients with end-stage HCM. Symptomatic improvement was associated with reverse remodelling of the left atrium and ventricle.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2008.03.006","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T15:38:36Z","timestamp":1207928316000},"page":"507-513","source":"Crossref","is-referenced-by-count":62,"title":["Effect of Biventricular Pacing on Symptoms and Cardiac Remodelling in Patients with End-Stage Hypertrophic Cardiomyopathy"],"prefix":"10.1093","volume":"10","author":[{"given":"Dominic P.S.","family":"Rogers","sequence":"first","affiliation":[{"name":"The Heart Hospital, University College London \u00a0","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Marazia","sequence":"additional","affiliation":[{"name":"The Heart Hospital, University College London \u00a0","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony 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