{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:49:53Z","timestamp":1792511393271,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of the right ventricle has been relatively neglected proportionate to its importance. We sought to evaluate the impact of right ventricular (RV) and NT-proBNP on the outcome of patients with heart failure (HF) and functional mitral regurgitation (MR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and patients<\/jats:title>\n                    <jats:p>Outpatients with left ventricular (LV) systolic HF (ejection fraction [EF] \u226445%) and moderate-to-severe MR measured by a vena contracta width \u22650.5 cm were prospectively enrolled (n=142). Indexes of LV and RV function, including tricuspid annular plane systolic excursion (TAPSE), RV fractional area change and tissue Doppler RV acceleration at isovolumic contraction and NT-proBNP plasma levels were measured at the time of the index echocardiogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariate predictors of all-cause mortality included TAPSE&amp;lt;16 mm (hazards ratio [HR]: 2.64; p=0.009) and plasma NT-proBNP\u22653283 pg\/ml (HR: 2.58; p=0.011). TAPSE&amp;lt;16mm and plasma NT-proBNP\u22653283 pg\/ml added incremental prognostic information to LV EF\u226425%, NYHA classes 3\u20134, coronary artery disease, elderly age and male sex. The 36-month Kaplan\u2013Meier curve showed that survival was worst in the group with TAPSE&amp;lt;16 mm and NT-proBNP\u22653283 pg\/ml (p&amp;lt;0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the significance of TAPSE and plasma NT-proBNP in predicting all-cause mortality in patients with systolic HF and moderate-to-severe functional MR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2008.04.003","type":"journal-article","created":{"date-parts":[[2008,5,24]],"date-time":"2008-05-24T06:17:54Z","timestamp":1211609874000},"page":"573-580","source":"Crossref","is-referenced-by-count":25,"title":["Prognostic Significance of Tricuspid Annular Motion and Plasma NT-proBNP in Patients with Heart Failure and Moderate-to-Severe Functional Mitral Regurgitation"],"prefix":"10.1093","volume":"10","author":[{"given":"Frank Lloyd","family":"Dini","sequence":"first","affiliation":[{"name":"Unit\u00e0 Malattie Cardiovascolari 2, Santa Chiara Hospital , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fontanive","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Malattie Cardiovascolari 2, Santa Chiara Hospital , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Panicucci","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Malattie Cardiovascolari 2, Santa Chiara Hospital , Pisa ,","place":["Italy"]},{"name":"Dipartimento di Patologia Sperimentale, Tecnologie Biomediche ed Epidemiologia, Universit\u00e0 di Pisa \u00a0","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Andreini","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Malattie Cardiovascolari 2, Santa Chiara Hospital , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piersilvio","family":"Chella","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Malattie Cardiovascolari 2, Santa Chiara Hospital , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Mario","family":"De Tommasi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Malattie Cardiovascolari 2, Santa Chiara Hospital , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2026020203425952400_ejhf2008-04-003-bib-0001","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0002-8703(91)90523-K","article-title":"Dilated cardiomyopathy with mitral regurgitation: decreased survival despite a low frequency of left ventricular thrombus","volume":"122","author":"Blondheim","year":"1991","journal-title":"Am Heart J"},{"key":"2026020203425952400_ejhf2008-04-003-bib-0002","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1161\/01.CIR.103.13.1759","article-title":"Ischemic mitral regurgitation. 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