{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:38:36Z","timestamp":1770068316110,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study was designed to assess whether the prognostic significance of estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF) interact in populations with heart failure (HF) and myocardial infarction (MI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were recruited from four screening registers (N=18,010) including patients admitted with HF or MI. Ten years follow-up was recorded and formal testing for interactions between eGFR and LVEF with respect to outcome was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve-thousand-and-ninety patients died. A significant interaction (P=0.010) was found and each parameter became relatively more important when the value of the other was low. eGFR and LVEF were reparameterized to categorical variables and we observed that chronic kidney disease stage II was associated with a decreased (Hazard ratio (HR): 0.79 (95% Confidence Interval: 0.72\u20130.86)) and chronic kidney disease stages IV (HR: 1.60 (1.45\u20131.91) and V (HR: 1.91 (1.45\u20132.52) were associated with an increased mortality risk with an additive effect of left ventricular systolic dysfunction (LVSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prognostic significance of eGFR and LVEF is synergistic in patients with HF or MI and the impact of one parameter is inversely related to the level of the other. Statistical interactions are scale dependent and the relationship between chronic kidney disease stages I to V and mortality risk is J-shaped with an additive effect of LVSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2008.04.006","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T04:55:59Z","timestamp":1213851359000},"page":"682-688","source":"Crossref","is-referenced-by-count":12,"title":["Wall Motion Index, Estimated Glomerular Filtration Rate and Mortality Risk in Patients with Heart Failure or Myocardial Infarction: A Pooled Analysis of 18,010 Patients"],"prefix":"10.1093","volume":"10","author":[{"given":"Morten","family":"Schou","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet University Hospital , DK-2100, Copenhagen O ,","place":["Denmark"]},{"name":"Department of Cardiology and Endocrinology, Frederiksberg University Hospital , DK-2000, Frederiksberg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital , DK-2900, Hellerup ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet University Hospital , DK-2100, Copenhagen O ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawdat","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Glostrup University Hospital , DK-2600, Glostrup ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Kober","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet University Hospital , DK-2100, Copenhagen O ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2026020203422669500_ejhf2008-04-006-bib-0001","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0735-1097(92)90167-L","article-title":"The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure","volume":"20","author":"Packer","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"2026020203422669500_ejhf2008-04-006-bib-0002","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/eurheartj\/ehi204","article-title":"Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology","volume":"26","author":"Swedberg","year":"2005","journal-title":"Eur Heart J"},{"key":"2026020203422669500_ejhf2008-04-006-bib-0003","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ejheart.2004.09.018","article-title":"Uric acid renal excretion and renal insufficiency in decompensated severe heart failure","volume":"7","author":"Ochiai","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"2026020203422669500_ejhf2008-04-006-bib-0004","doi-asserted-by":"crossref","first-page":"S234","DOI":"10.1046\/j.1523-1755.2001.59780234.x","article-title":"Homocysteine metabolism in renal failure","volume":"78","author":"van Guldener","year":"2001","journal-title":"Kidney Int Suppl"},{"key":"2026020203422669500_ejhf2008-04-006-bib-0005","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/oxfordjournals.eurheartj.a060443","article-title":"Echocardiographic methods for selecting high risk patients shortly after acute myocardial infarction, for inclusion in multi-centre studies (as used in the TRACE study). 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