{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:00:48Z","timestamp":1770058848156,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T00:00:00Z","timestamp":1224547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated diastolic functional reserve in 108 patients with normal left ventricular ejection fraction (LVEF) \u2265 50% but abnormal relaxation (ratio of transmitral peak velocity of early and late diastolic flow (E\/A)&amp;lt;1) using passive leg lifting. We calculated the pulmonary venous systolic to diastolic flow ratio (S\/D) as a marker of left atrial reservoir function, and the time difference between the duration of pulmonary venous retrograde flow (PVAd) and the duration of the mitral A wave (PVAd-Ad) as a marker of left ventricular end-diastolic pressure (LVEDP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During leg lifting, the E\/A was \u2265 1 in 39 patients (the inverted group); the remaining 69 patients comprised the stable group. Comparing the inverted group with the stable group at baseline, S\/D was smaller (1.5\u00b10.4 vs. 1.8\u00b10.5, P=0.002) and PVAd-Ad greater (11\u00b123 ms vs. \u221223\u00b128 ms, P&amp;lt;0.001).Multiple logistic regression analysis revealed that PVAd-Ad and S\/D predicted E\/A inversion with leg lifting after adjustment for age, LV wall thickness, LV dimension, LVEF, deceleration time of E, and E\/E'.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with preserved LVEF but early diastolic dysfunction, passive leg lifting may identify patients having a less compliant left ventricle and impaired left atrial reservoir function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2008.07.011","type":"journal-article","created":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T09:23:19Z","timestamp":1219915399000},"page":"1094-1101","source":"Crossref","is-referenced-by-count":13,"title":["Stratification of Impaired Relaxation Filling Patterns by Passive Leg Lifting in Patients with Preserved Left Ventricular Ejection Fraction"],"prefix":"10.1093","volume":"10","author":[{"given":"Tomoko","family":"Ishizu","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Seo","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kawano","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Ishimitsu","sequence":"additional","affiliation":[{"name":"Ibaraki Medical Center 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