{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:54:42Z","timestamp":1776477282223,"version":"3.51.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maternal and neonatal complication rates are increased in pregnant women with heart disease. Cardiac risk assessment may be improved by defining low and high-risk groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To analyze pregnancy risks in low and high-risk women with cardiovascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Pregnancy outcomes were analyzed in 93 consecutive women with heart disease, monitored in a single-centre cohort between 1996 and 2006. Women were classified according to pre-defined risk predictors as high-risk (left ventricular [LV] ejection fraction &amp;lt;50%, NYHA class&amp;gt;II or cyanosis, peak LV outflow gradient &amp;gt;60 mmHg) or low-risk (not meeting these criteria). Mean age was 28.1\u00b15.7 years. 81.7% presented with congenital, 10.8% with acquired heart disease, and 7.5% with myocardial diseases. Severe maternal complications developed in 12.9% of all women: 6.5% heart failure, 3.2% arrhythmias, and 2.2% thrombotic complications. Maternal mortality was 1.1%. Women at high-risk (24.7%) had a 6.1-fold higher maternal complication rate and a 6.1 times higher foetal\/neonatal event rate (abortion and stillbirth). 64.7% of the high-risk women delivered prematurely, before the 37th week, compared to 16.4% in the low-risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite pronounced clinical variability of congenital and acquired heart diseases, a small number of risk conditions can effectively characterize women in whom pregnancy is associated with appreciably increased maternal and foetal risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2008.07.017","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T10:40:46Z","timestamp":1220006446000},"page":"855-860","source":"Crossref","is-referenced-by-count":66,"title":["Maternal Heart Disease and Pregnancy Outcome: A Single-Centre Experience"],"prefix":"10.1093","volume":"10","author":[{"given":"Verena","family":"Stangl","sequence":"first","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie , Charit\u00e9platz 1, D-10117, Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Schad","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie , Charit\u00e9platz 1, D-10117, Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Gossing","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Geburtsmedizin Universit\u00e4tsmedizin Berlin , Charit\u00e9 Campus Mitte ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Borges","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie , Charit\u00e9platz 1, D-10117, Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Baumann","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie , Charit\u00e9platz 1, D-10117, Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Stangl","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie , Charit\u00e9platz 1, D-10117, Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2026020203414811400_ejhf2008-07-017-bib-0001","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00002727-200601000-00004","article-title":"Cardiac disease in pregnancy","volume":"29","author":"Arafeh","year":"2006","journal-title":"Crit Care Nurs 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