{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:22:18Z","timestamp":1780964538651,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T00:00:00Z","timestamp":1227916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ratio of effective arterial elastance (Ea) to ventricular end-systolic elastance (Ees) indicates the status of ventriculo-arterial coupling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated if systolic time intervals (pre-ejection period, PEP; ejection time, ET; and their ratio, PEP\/ET) can be used to identify heart failure patients with abnormal ventriculo-arterial coupling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Age and sex-matched study subjects included 54 apparently healthy subjects with normal left ventricular (LV) function, and stable patients with LV diastolic (n=54) and systolic dysfunction (n=54). Ees and Ea were estimated non-invasively by echocardiography, and abnormal ventriculo-arterial coupling was defined as Ea\/Ees&amp;gt;1.2. PEP, ET, and PEP\/ET were measured automatically using electrocardiography, phonocardiography, and brachial pulse volume recording.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ea\/Ees&amp;gt;1.2 was present in 48.1% of subjects with systolic dysfunction. The PEP\/ET was significantly associated with most parameters of LV structure and function, and Ea\/Ees (r=0.67, p&amp;lt;0.001). Using PEP\/ET\u22650.423 as cut point, the sensitivity and specificity to identify patients with Ea\/Ees&amp;gt;1.2 were 85.7% and 84.3%, respectively for the whole population, and 84.6% and 78.6%, for patients with systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal ventriculo-arterial coupling was present in almost half of stable patients with systolic dysfunction. PEP\/ET was useful in identifying such patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2008.09.003","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T08:05:28Z","timestamp":1226477128000},"page":"1192-1200","source":"Crossref","is-referenced-by-count":27,"title":["Usefulness of Systolic Time Intervals in the Identification of Abnormal Ventriculo-Arterial Coupling in Stable Heart Failure Patients"],"prefix":"10.1093","volume":"10","author":[{"given":"Hao-Min","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Research and Education \u00a0","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chung","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Taipei Veterans General Hospital \u00a0","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsien","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Taipei Veterans General Hospital \u00a0","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Taipei Veterans General Hospital \u00a0","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yuan","family":"Chuang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Research and Education \u00a0","place":["Taiwan"]},{"name":"Cardiovascular Research Center \u00a0","place":["Taiwan"]},{"name":"Department of Public Health \u00a0","place":["Taiwan"]},{"name":"I-Lan University Hospital, National Yang-Ming University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,11,29]]},"reference":[{"key":"2026020203404823600_ejhf2008-09-003-bib-0001","first-page":"e154","article-title":"ACC\/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society","volume":"112","author":"Hunt","year":"2005","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0002","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/eurheartj\/ehi204","article-title":"Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology","volume":"26","author":"Swedberg","year":"2005","journal-title":"Eur Heart J"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0003","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0735-1097(91)90728-R","article-title":"Ventricular load optimization by unloading therapy in patients with heart failure","volume":"17","author":"Kameyama","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0004","doi-asserted-by":"crossref","first-page":"H477","DOI":"10.1152\/ajpheart.1985.248.4.H477","article-title":"Stroke volume effect of changing arterial input impedance over selected frequency ranges","volume":"248","author":"Sunagawa","year":"1985","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0005","first-page":"R1021","article-title":"Ventricular efficiency predicted by an analytical model","volume":"250","author":"Burkhoff","year":"1986","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0006","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/01.RES.56.4.586","article-title":"Optimal arterial resistance for the maximal stroke work studied in isolated canine ventricle","volume":"56","author":"Sunagawa","year":"1985","journal-title":"Circ Res"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0007","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1056\/NEJMoa042934","article-title":"Combination of isosorbide dinitrate and hydralazine in blacks with heart failure","volume":"351","author":"Taylor","year":"2004","journal-title":"N Engl J Med"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0008","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.CIR.56.2.146","article-title":"A critical review of the systolic time intervals","volume":"56","author":"Lewis","year":"1977","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0009","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/01.CIR.42.3.455","article-title":"The relationship of alterations in systolic time intervals to ejection fraction in patients with cardiac disease","volume":"42","author":"Garrard","year":"1970","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJM197702102960607","article-title":"Current concept in cardiology: systolic time intervals","volume":"296","author":"Weissler","year":"1977","journal-title":"N Engl J Med"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0011","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1542-474X.2007.00146.x","article-title":"Performance of phonoelectrocardiographic left ventricular systolic time intervals and B-type natriuretic peptide levels in the diagnosis of left ventricular dysfunction","volume":"12","author":"Moyers","year":"2007","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0012","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cardfail.2006.09.009","article-title":"Diagnostic characteristics of combining phonocardiographic third heart sound and systolic time intervals for the prediction of left ventricular dysfunction","volume":"13","author":"Shapiro","year":"2007","journal-title":"J Card Fail"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0013","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.amjcard.2004.07.094","article-title":"Time intervals of cardiac resynchronization therapy in heart failure","volume":"94","author":"Baker","year":"2004","journal-title":"Am J Cardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0014","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1097\/00000542-200006000-00037","article-title":"Single-beat estimation of ventricular end-systolic elastance-effective arterial elastance as an index of ventricular mechanoenergetic performance","volume":"92","author":"Hayashi","year":"2000","journal-title":"Anesthesiology"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0015","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1046\/j.1523-1755.2002.00610.x","article-title":"Left ventricular mass and hemodynamic overload in normotensive hemodialysis patients","volume":"62","author":"Lin","year":"2002","journal-title":"Kidney Int"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0016","doi-asserted-by":"crossref","first-page":"6A","DOI":"10.1016\/0735-1097(93)90455-A","article-title":"The epidemiology of heart failure: the Framingham Study","volume":"22","author":"Ho","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0017","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","article-title":"Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements","volume":"58","author":"Sahn","year":"1978","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0018","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0735-1097(02)02337-9","article-title":"Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony","volume":"40","author":"Pitzalis","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0019","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/S0735-1097(01)01651-5","article-title":"Noninvasive single-beat determination of left ventricular end-systolic elastance in humans","volume":"38","author":"Chen","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0020","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0002-9149(97)00015-5","article-title":"Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation","volume":"79","author":"Oki","year":"1997","journal-title":"Am J Cardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0021","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa032566","article-title":"Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle","volume":"350","author":"Zile","year":"2004","journal-title":"N Engl J Med"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0022","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/eurheartj\/ehm037","article-title":"How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology","volume":"28","author":"Paulus","year":"2007","journal-title":"Eur Heart J"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0023","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/01.CIR.86.2.513","article-title":"Effective arterial elastance as index of arterial vascular load in humans","volume":"86","author":"Kelly","year":"1992","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0024","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1023\/A:1013749806227","article-title":"Age-related changes in ventricular-arterial coupling: pathophysiologic implications","volume":"7","author":"Kass","year":"2002","journal-title":"Heart Fail Rev"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijcard.2004.01.019","article-title":"Combined use of brachial-ankle pulse wave velocity and ankle-brachial index for fast assessment of arteriosclerosis and atherosclerosis in a community","volume":"98","author":"Chuang","year":"2005","journal-title":"Int J Cardiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0026","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.CIR.37.2.149","article-title":"Systolic time intervals in heart failure in man","volume":"37","author":"Weissler","year":"1968","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0027","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.RES.65.2.483","article-title":"Ventriculoarterial coupling in normal and failing heart in humans","volume":"65","author":"Asanoi","year":"1989","journal-title":"Circ Res"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0028","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJM198606123142404","article-title":"Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study","volume":"314","author":"Cohn","year":"1986","journal-title":"N Engl J Med"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0029","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/01.CIR.83.1.202","article-title":"Single-beat estimation of the slope of the end-systolic pressure-volume relation in the human left ventricle","volume":"83","author":"Takeuchi","year":"1991","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0030","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/01.CIR.94.10.2497","article-title":"Single-beat estimation of end-systolic pressure-volume relation in humans. A new method with the potential for noninvasive application","volume":"94","author":"Senzaki","year":"1996","journal-title":"Circulation"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0031","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/HYPERTENSIONAHA.107.097964","article-title":"Arterioventricular coupling and ventricular efficiency after antihypertensive therapy: a noninvasive prospective study","volume":"51","author":"Osranek","year":"2008","journal-title":"Hypertension"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0032","doi-asserted-by":"crossref","first-page":"H1739","DOI":"10.1152\/ajpheart.00638.2001","article-title":"Pressure-volume-based single-beat estimations cannot predict left ventricular contractility in vivo","volume":"282","author":"Kjorstad","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0033","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1097\/01.CCM.0000139607.38497.8A","article-title":"Comparison between single-beat and multiple-beat methods for estimation of right ventricular contractility","volume":"32","author":"Lambermont","year":"2004","journal-title":"Crit Care Med"},{"key":"2026020203404823600_ejhf2008-09-003-bib-0034","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1152\/japplphysiol.00976.2006","article-title":"The effect of a myocardial infarction on the normalized time-varying elastance curve","volume":"102","author":"Jegger","year":"2007","journal-title":"J Appl Physiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejheart.2008.09.003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/10\/12\/1192\/66563856\/eurjhf_10_12_1192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/10\/12\/1192\/66563856\/eurjhf_10_12_1192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:40:56Z","timestamp":1770021656000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/10\/12\/1192\/8439789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,29]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2008,11,29]]},"published-print":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ejheart.2008.09.003","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,12]]},"published":{"date-parts":[[2008,11,29]]}}}