{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:11:39Z","timestamp":1784153499435,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ejim.2007.04.016","type":"journal-article","created":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T11:10:45Z","timestamp":1185275445000},"page":"1-7","source":"Crossref","is-referenced-by-count":28,"title":["Causes and mechanisms of acid\u2013base and electrolyte abnormalities in cancer patients"],"prefix":"10.1016","volume":"19","author":[{"given":"George","family":"Miltiadous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Christidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Kalogirou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Elisaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib1","first-page":"322","article-title":"Metabolic emergencies in the cancer patient","volume":"27","author":"Flombaum","year":"2000","journal-title":"Semin Oncol"},{"issue":"1","key":"10.1016\/j.ejim.2007.04.016_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00006123-199601000-00035","article-title":"Cerebral salt wasting syndrome: a review","volume":"38","author":"Harrigan","year":"1996","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.ejim.2007.04.016_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2796.1995.tb00907.x","article-title":"Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease","volume":"238","author":"Sorensen","year":"1995","journal-title":"J Intern Med"},{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/mpo.2950080312","article-title":"Studies on the antidiuretic effect of cyclophosphamide: vasopressin release and sodium excretion","volume":"8","author":"Bode","year":"1980","journal-title":"Med Pediatr Oncol"},{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/pds.695","article-title":"Hyponatremia and syndrome of inappropriate anti-diuretic hormone reported with the use of Vincristine: an over-representation of Asians?","volume":"11","author":"Hammond","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/1097-0142(19880201)61:3<448::AID-CNCR2820610307>3.0.CO;2-#","article-title":"Cis-dichlorodiammineplatinum II-induced syndrome of inappropriate secretion of antidiuretic hormone","volume":"61","author":"Ritch","year":"1988","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib7","first-page":"151","article-title":"Syndrome of inappropriate antidiuretic hormone secretion due to recurrent oral cancer","volume":"1","author":"Danielides","year":"2005","journal-title":"B-ENT"},{"issue":"2","key":"10.1016\/j.ejim.2007.04.016_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9343(92)90055-G","article-title":"Chronic hyponatremia due to resetting of the osmostat in a patient with gastric carcinoma","volume":"93","author":"Wall","year":"1992","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.ejim.2007.04.016_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000169090","article-title":"Chronic hyponatremia due to recent osmostat in a patient with colon cancer","volume":"17","author":"Elisaf","year":"1997","journal-title":"Am J Nephrol"},{"issue":"8","key":"10.1016\/j.ejim.2007.04.016_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/21548331.1994.11443061","article-title":"Case in point. Pseudohyponatremia due to hyperproteinemia in multiple myeloma","volume":"29","author":"Olivero","year":"1994","journal-title":"Hosp Pract (Off Ed)"},{"issue":"Suppl 2","key":"10.1016\/j.ejim.2007.04.016_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000073351","article-title":"Side effects of ifosfamide","volume":"65","author":"Klastersky","year":"2003","journal-title":"Oncology"},{"issue":"7","key":"10.1016\/j.ejim.2007.04.016_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00043426-200407000-00004","article-title":"Amphotericin B nephrotoxicity in children","volume":"26","author":"Goldman","year":"2004","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.ejim.2007.04.016_bib13","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/bmj.282.6269.1034","article-title":"Exaggerated hypokalaemia in acute myeloid leukaemia","volume":"282","author":"Adams","year":"1981","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.ejim.2007.04.016_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000086055","article-title":"Cisplatin-associated nephrotoxicity and pathological events","volume":"148","author":"Taguchi","year":"2005","journal-title":"Contrib Nephrol"},{"issue":"6","key":"10.1016\/j.ejim.2007.04.016_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1600-0609.2005.00547.x","article-title":"Alterations in electrolyte equilibrium in patients with acute leukemia","volume":"75","author":"Filippatos","year":"2005","journal-title":"Eur J Haematol"},{"issue":"4","key":"10.1016\/j.ejim.2007.04.016_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1096-8652(199912)62:4<201::AID-AJH1>3.0.CO;2-1","article-title":"Acid\u2013base and electrolyte abnormalities in patients with acute leukemia","volume":"62","author":"Milionis","year":"1999","journal-title":"Am J Hematol"},{"issue":"4","key":"10.1016\/j.ejim.2007.04.016_bib17","first-page":"660","article-title":"Pseudohyperkalemia and extreme leukocytosis","volume":"85","author":"Bellevue","year":"1975","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.ejim.2007.04.016_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/07853890510007205","article-title":"Acute renal failure in cancer patients","volume":"37","author":"Lameire","year":"2005","journal-title":"Ann Med"},{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/mpo.10335","article-title":"Cisplatin nephrotoxicity affects magnesium and calcium metabolism","volume":"41","author":"Goren","year":"2003","journal-title":"Med Pediatr Oncol"},{"issue":"5","key":"10.1016\/j.ejim.2007.04.016_bib20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00280-005-1010-7","article-title":"Magnesium depletion enhances cisplatin-induced nephropathy","volume":"56","author":"Lajer","year":"2005","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3\u20134","key":"10.1016\/j.ejim.2007.04.016_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000180457","article-title":"Hypomagnesemia following the diuresis of post-renal obstruction and renal transplant","volume":"14","author":"Davis","year":"1975","journal-title":"Nephron"},{"issue":"6","key":"10.1016\/j.ejim.2007.04.016_bib22","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0889-8588(05)70126-X","article-title":"Acquired Fanconi's syndrome associated with monoclonal gammopathies","volume":"13","author":"Lacy","year":"1999","journal-title":"Hematol Oncol Clin North Am"},{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0272-6386(97)90207-9","article-title":"Profound hypophosphatemia and isolated hyperphosphaturia in two cases of multiple myeloma","volume":"29","author":"Dash","year":"1997","journal-title":"Am J Kidney Dis"},{"issue":"2 Pt 1","key":"10.1016\/j.ejim.2007.04.016_bib24","first-page":"289","article-title":"Nephrotoxicity of ifosfamide with special reference to Fanconi Syndrome","volume":"8","author":"Rogowska","year":"2004","journal-title":"Med Wieku Rozwoj"},{"issue":"17","key":"10.1016\/j.ejim.2007.04.016_bib25","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMe030037","article-title":"Oncogenic osteomalacia\u2014a complex dance of factors","volume":"348","author":"Carpenter","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2007.04.016_bib26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0022-5347(01)64351-9","article-title":"Oncogenic osteomalakia associated with prostate cancer","volume":"158","author":"Reese","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.ejim.2007.04.016_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2004.09.017","article-title":"Severe hypophosphatemic osteomalakia in hormone-refractory prostate cancer metastatic to the skeleton: natural history and pitfalls in management","volume":"36","author":"Pelger","year":"2005","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.ejim.2007.04.016_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cytogfr.2005.01.002","article-title":"FGF23 and disorders of phosphate homeostasis","volume":"16","author":"Yu","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"issue":"4","key":"10.1016\/j.ejim.2007.04.016_bib29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1034\/j.1600-0609.2000.9l123.x","article-title":"Hypokalemia, hypophosphatemia and hypouricemia due to proximal renal tubular dysfunction in acute myeloid leukemia","volume":"64","author":"Liamis","year":"2000","journal-title":"Eur J Haematol"},{"issue":"2","key":"10.1016\/j.ejim.2007.04.016_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/01.sla.0000152093.43468.c0","article-title":"Hepatic resection-related hypophosphatemia is of renal origin as manifested by isolated hyperphosphaturia","volume":"241","author":"Salem","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejim.2007.04.016_bib31","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/clinchem\/36.6.1261","article-title":"Excessive sample blanking in two analyzers generate reports of apparent hypoglycemia and hypophosphatemia in patients with macroglobulinemia","volume":"36","author":"Tokmakjian","year":"1990","journal-title":"Clin Chem"},{"issue":"9124","key":"10.1016\/j.ejim.2007.04.016_bib32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0140-6736(97)12331-5","article-title":"Electrolyte quintet: calcium","volume":"352","author":"Bushinsky","year":"1998","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ejim.2007.04.016_bib33","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/jcb.10662","article-title":"Prostate cancer bone metastases promote both osteolytic and osteoblastic activity","volume":"91","author":"Keller","year":"2004","journal-title":"J Cell Biochem"},{"issue":"2","key":"10.1016\/j.ejim.2007.04.016_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0002-9343(97)80047-2","article-title":"Hypercalcemia of malignancy","volume":"103","author":"Mundy","year":"1997","journal-title":"Am J Med"},{"key":"10.1016\/j.ejim.2007.04.016_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJMcp042806","article-title":"Hypercalcemia associated with cancer","volume":"352","author":"Steward","year":"2005","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.ejim.2007.04.016_bib36","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI118947","article-title":"Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis","volume":"98","author":"Guise","year":"1996","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.ejim.2007.04.016_bib37","first-page":"291","article-title":"Bone destruction and hypercalcemia in plasma cell myeloma","volume":"13","author":"Mundy","year":"1986","journal-title":"Semin Oncol"},{"issue":"5","key":"10.1016\/j.ejim.2007.04.016_bib38","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood.V82.5.1383.1383","article-title":"Calcitriol: the major humoral mediator of hypercalcemia in Hodgkin's disease and non-Hodgkin's lymphomas","volume":"82","author":"Seymour","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.ejim.2007.04.016_bib39","first-page":"61","article-title":"Incidence and pathogenesis of tumor lysis syndrome","volume":"147","author":"Locatelli","year":"2005","journal-title":"Contrib Nephrol"},{"issue":"4","key":"10.1016\/j.ejim.2007.04.016_bib40","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00007611-198804000-00034","article-title":"Malignancy-induced lactic acidosis","volume":"81","author":"Doolittle","year":"1988","journal-title":"South Med J"},{"issue":"5","key":"10.1016\/j.ejim.2007.04.016_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0277-5379(83)90174-8","article-title":"Lactic acidosis: a metabolic complication of extensive metastatic cancer","volume":"19","author":"Sculier","year":"1983","journal-title":"Eur J Cancer Clin Oncol"},{"issue":"1","key":"10.1016\/j.ejim.2007.04.016_bib42","first-page":"15","article-title":"Lactate and short chain fatty acid production in the human colon: implications for D-lactic acidosis, short-bowel syndrome, antibiotic-associated diarrhea, colonic cancer and inflammatory bowel disease","volume":"45","author":"Hove","year":"1998","journal-title":"Dan Med Bull"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620507001859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620507001859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T09:33:52Z","timestamp":1587807232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620507001859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0953620507001859"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2007.04.016","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}