{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:10:50Z","timestamp":1768702250634,"version":"3.49.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.ejim.2009.08.007","type":"journal-article","created":{"date-parts":[[2009,9,20]],"date-time":"2009-09-20T08:50:15Z","timestamp":1253436615000},"page":"749-755","source":"Crossref","is-referenced-by-count":9,"title":["Peptidylarginine deiminases and the pathogenesis of rheumatoid arthritis"],"prefix":"10.1016","volume":"20","author":[{"given":"P\u00e5l","family":"Stenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank A.","family":"Wollheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ejim.2009.08.007_bib1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1471-4906(01)01976-7","article-title":"Post-translational protein modifications in antigen recognition and autoimmunity","volume":"22","author":"Doyle","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ejim.2009.08.007_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1313.001","article-title":"Posttranslational modifications of self-antigens","volume":"1050","author":"Doyle","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ejim.2009.08.007_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1196\/annals.1384.003","article-title":"Autoimmune diseases and Sjogren's syndrome: an autoimmune exocrinopathy","volume":"1098","author":"Fox","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ejim.2009.08.007_bib4","unstructured":"Committee, T.A.D.C., Progress in autoimmune disease research: a report to congress. U.S. Department of Health and Human Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases. (Access at www.niaid.nih.gov\/publications\/pdf\/ADCCFinal.pdf). 2005."},{"key":"10.1016\/j.ejim.2009.08.007_bib5","doi-asserted-by":"crossref","first-page":"723539","DOI":"10.1155\/2008\/723539","article-title":"Antigen-induced immunomodulation in the pathogenesis of atherosclerosis.","volume":"2008","author":"Milioti","year":"2008","journal-title":"Clin Dev Immunol"},{"issue":"4","key":"10.1016\/j.ejim.2009.08.007_bib6","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/j.1582-4934.2008.00313.x","article-title":"Biomarkers for early diagnosis of Alzheimer disease: 'ALZheimer ASsociated gene'\u2013a new blood biomarker?","volume":"12","author":"Jellinger","year":"2008","journal-title":"J Cell Mol Med"},{"issue":"7","key":"10.1016\/j.ejim.2009.08.007_bib7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.ejim.2009.08.007_bib8","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/j.1538-7836.2005.01213.x","article-title":"Factor XIII and the clotting of fibrinogen: from basic research to medicine","volume":"3","author":"Lorand","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000073710","article-title":"Pathomechanisms in celiac disease","volume":"132","author":"Dieterich","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejim.2007.05.012","article-title":"Transglutaminase and the pathogenesis of coeliac disease","volume":"19","author":"Stenberg","year":"2008","journal-title":"Eur J Intern Med"},{"issue":"10","key":"10.1016\/j.ejim.2009.08.007_bib11","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.biocel.2006.03.008","article-title":"Citrullination: a posttranslational modification in health and disease","volume":"38","author":"Gyorgy","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"issue":"48","key":"10.1016\/j.ejim.2009.08.007_bib12","doi-asserted-by":"crossref","first-page":"30709","DOI":"10.1074\/jbc.271.48.30709","article-title":"Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin","volume":"271","author":"Tarcsa","year":"1996","journal-title":"J Biol Chem"},{"issue":"44","key":"10.1016\/j.ejim.2009.08.007_bib13","doi-asserted-by":"crossref","first-page":"27893","DOI":"10.1074\/jbc.272.44.27893","article-title":"The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases","volume":"272","author":"Tarcsa","year":"1997","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11064-006-9108-9","article-title":"A tale of two citrullines\u2014structural and functional aspects of myelin basic protein deimination in health and disease","volume":"32","author":"Harauz","year":"2007","journal-title":"Neurochem Res"},{"issue":"11","key":"10.1016\/j.ejim.2009.08.007_bib15","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/bies.10357","article-title":"PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease","volume":"25","author":"Vossenaar","year":"2003","journal-title":"Bioessays"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4049\/jimmunol.162.1.585","article-title":"The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues","volume":"162","author":"Girbal-Neuhauser","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ejim.2009.08.007_bib17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1196\/annals.1443.013","article-title":"Anti-CCP antibody, a marker for the early detection of rheumatoid arthritis","volume":"1143","author":"van Venrooij","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.1016\/j.ejim.2009.08.007_bib18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/ard.2008.091355","article-title":"Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles","volume":"68","author":"Snir","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.ejim.2009.08.007_bib19","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantapaa-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.ejim.2009.08.007_bib21","doi-asserted-by":"crossref","first-page":"R458","DOI":"10.1186\/ar1697","article-title":"Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity","volume":"7","author":"Lundberg","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.20081862","article-title":"Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis","volume":"206","author":"Uysal","year":"2009","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib23","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4049\/jimmunol.171.2.538","article-title":"Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule","volume":"171","author":"Hill","year":"2003","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.ejim.2009.08.007_bib24","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/art.23596","article-title":"Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis","volume":"58","author":"Harris","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.ejim.2009.08.007_bib25","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/art.20316","article-title":"Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis","volume":"50","author":"van Gaalen","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/art.21536","article-title":"A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans","volume":"54","author":"Kang","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.ejim.2009.08.007_bib27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ng1206","article-title":"Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis","volume":"34","author":"Suzuki","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejim.2009.08.007_bib28","article-title":"PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian Population","author":"Burr","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2009.08.007_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1196\/annals.1423.004","article-title":"Genetic background of anticyclic citrullinated peptide autoantibody production in Hungarian patients with rheumatoid arthritis","volume":"1110","author":"Poor","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"10.1016\/j.ejim.2009.08.007_bib30","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/rheumatology\/kel023","article-title":"Association between PADI4 and rheumatoid arthritis: a meta-analysis","volume":"45","author":"Iwamoto","year":"2006","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"10.1016\/j.ejim.2009.08.007_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1467-2494.2007.00377.x","article-title":"Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases","volume":"29","author":"Mechi","year":"2007","journal-title":"Int J Cosmet Sci"},{"issue":"31","key":"10.1016\/j.ejim.2009.08.007_bib32","doi-asserted-by":"crossref","first-page":"10570","DOI":"10.1021\/bi050292m","article-title":"Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis","volume":"44","author":"Kearney","year":"2005","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.ejim.2009.08.007_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/03009740510026346-1","article-title":"Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritis","volume":"34","author":"Takizawa","year":"2005","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.ejim.2009.08.007_bib34","series-title":"Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases","author":"Roth","year":"2008"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib35","first-page":"12","article-title":"Antibodies against transglutaminases, peptidylarginine deiminase and citrulline in rheumatoid arthritis\u2013new pathways to epitope spreading","volume":"24","author":"Roth","year":"2006","journal-title":"Clin Exp Rheumatol"},{"issue":"6","key":"10.1016\/j.ejim.2009.08.007_bib36","first-page":"969","article-title":"Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis","volume":"35","author":"Zhao","year":"2008","journal-title":"J Rheumatol"},{"issue":"3","key":"10.1016\/j.ejim.2009.08.007_bib37","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/ard.2007.080267","article-title":"Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity","volume":"67","author":"Halvorsen","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.ejim.2009.08.007_bib38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/03009740410004990","article-title":"Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren syndrome","volume":"32","author":"Nissinen","year":"2003","journal-title":"Scand J Rheumatol"},{"issue":"4","key":"10.1016\/j.ejim.2009.08.007_bib39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/0891693031000118974","article-title":"Biochemical and immuno-pathological aspects of tissue transglutaminase in coeliac disease","volume":"36","author":"Roth","year":"2003","journal-title":"Autoimmunity"},{"issue":"1-2","key":"10.1016\/j.ejim.2009.08.007_bib40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cccn.2005.02.027","article-title":"Calcium activation of tissue transglutaminase in radioligand binding and enzyme-linked autoantibody immunoassays in childhood celiac disease","volume":"358","author":"Agardh","year":"2005","journal-title":"Clin Chim Acta"},{"issue":"6","key":"10.1016\/j.ejim.2009.08.007_bib41","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1365-3083.2008.02115.x","article-title":"Pathogenesis of Autoimmune Diseases: Antibodies Against Transglutaminase, Peptidylarginine Deiminase and Protein-bound Citrulline in Primary Sjogren\"s Syndrome, Multiple Sclerosis and Alzheimer\"s Disease","volume":"67","author":"Roth","year":"2008","journal-title":"Scand J Immunol"},{"issue":"5","key":"10.1016\/j.ejim.2009.08.007_bib42","first-page":"920","article-title":"Antibodies to tissue transglutaminase and Saccharomyces cerevisiae in ankylosing spondylitis and psoriatic arthritis","volume":"31","author":"Riente","year":"2004","journal-title":"J Rheumatol"},{"issue":"12","key":"10.1016\/j.ejim.2009.08.007_bib43","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1373\/clinchem.2003.023234","article-title":"Anti-tissue transglutaminase antibodies in arthritic patients: a disease-specific finding?","volume":"49","author":"Picarelli","year":"2003","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2796.2007.01881.x","article-title":"Antitissue transglutaminase antibodies in acute coronary syndrome: an alert signal of myocardial tissue lesion?","volume":"263","author":"Di Tola","year":"2008","journal-title":"J Intern Med"},{"issue":"Suppl 3","key":"10.1016\/j.ejim.2009.08.007_bib45","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1186\/ar578","article-title":"Epidemiology and genetics of rheumatoid arthritis","volume":"4","author":"Silman","year":"2002","journal-title":"Arthritis Res"},{"issue":"6","key":"10.1016\/j.ejim.2009.08.007_bib46","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1210\/endo-124-6-2666","article-title":"Peptidylarginine deiminase in rat pituitary: sex difference, estrous cycle-related changes, and estrogen dependence","volume":"124","author":"Senshu","year":"1989","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2217\/17455057.4.2.195","article-title":"Rheumatoid arthritis: a female challenge","volume":"4","author":"Gerosa","year":"2008","journal-title":"Womens Health (Lond Engl)"},{"issue":"5","key":"10.1016\/j.ejim.2009.08.007_bib48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1600-0609.1991.tb01537.x","article-title":"Transglutaminase differentiation during maturation of human blood monocytes to macrophages","volume":"46","author":"Seiving","year":"1991","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.ejim.2009.08.007_bib49","series-title":"15th International Congress of Rheumatology","article-title":"Characterisation of transglutaminases in plasma and synovial fluid from patients with arthritis","author":"Wollheim","year":"1981"},{"issue":"4","key":"10.1016\/j.ejim.2009.08.007_bib50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/ard.2003.012211","article-title":"Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages","volume":"63","author":"Vossenaar","year":"2004","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.ejim.2009.08.007_bib51","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1139\/O08-124","article-title":"Kinetics of human peptidylarginine deiminase 2 (hPAD2)\u2013reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains","volume":"86","author":"Musse","year":"2008","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.ejim.2009.08.007_bib52","series-title":"Fed. Proc","article-title":"Inhibition of fibrinoligase and transglutaminase by zinc ions","author":"Credo","year":"1976"},{"issue":"43","key":"10.1016\/j.ejim.2009.08.007_bib53","doi-asserted-by":"crossref","first-page":"17040","DOI":"10.1073\/pnas.0705894104","article-title":"The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes","volume":"104","author":"Wenzlau","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.ejim.2009.08.007_bib54","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jdiacomp.2004.12.003","article-title":"Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes","volume":"19","author":"Agardh","year":"2005","journal-title":"J Diabetes Complications"},{"issue":"7832","key":"10.1016\/j.ejim.2009.08.007_bib55","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(73)91037-4","article-title":"Association of autoantibodies with smoking, cardiovascular morbidity, and death in the Busselton population","volume":"2","author":"Mathews","year":"1973","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ejim.2009.08.007_bib56","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/art.1780390504","article-title":"Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins","volume":"39","author":"Silman","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejim.2009.08.007_bib57","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1146\/annurev.immunol.26.021607.090244","article-title":"Immunity to citrullinated proteins in rheumatoid arthritis","volume":"26","author":"Klareskog","year":"2008","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"10.1016\/j.ejim.2009.08.007_bib58","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1136\/ard.2007.075192","article-title":"Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells","volume":"67","author":"Makrygiannakis","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jlb.42.1.9","article-title":"Characterization of two distinct transglutaminases of murine bone marrow-derived macrophages: effects of exposure of viable cells to cigarette smoke on enzyme activity","volume":"42","author":"Roth","year":"1987","journal-title":"J Leukoc Biol"},{"issue":"4560","key":"10.1016\/j.ejim.2009.08.007_bib60","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1126\/science.6124042","article-title":"Cigarette smoke contains anticoagulants against fibrin aggregation and factor XIIIa in plasma","volume":"217","author":"Galanakis","year":"1982","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ejim.2009.08.007_bib61","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/rheumatology\/41.5.563","article-title":"Risk factors for developing systemic lupus erythematosus: a case-control study in southern Sweden","volume":"41","author":"Bengtsson","year":"2002","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib62","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.0608620104","article-title":"Ethanol prevents development of destructive arthritis","volume":"104","author":"Jonsson","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib63","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/ard.2007.086314","article-title":"Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies","volume":"68","author":"Kallberg","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.ejim.2009.08.007_bib64","first-page":"995","article-title":"Anti-cyclic citrullinated peptide antibody, smoking, alcohol consumption, and disease duration as risk factors for extraarticular manifestations in Korean patients with rheumatoid arthritis","volume":"35","author":"Kim","year":"2008","journal-title":"J Rheumatol"},{"issue":"12","key":"10.1016\/j.ejim.2009.08.007_bib65","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1007\/s10620-007-9754-z","article-title":"The effect of acetaldehyde on human plasma factor XIII function","volume":"52","author":"Suchocki","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ejim.2009.08.007_bib66","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"10.1016\/j.ejim.2009.08.007_bib67","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1460-9568.2007.05737.x","article-title":"Sensory nerves have altered function contralateral to a monoarthritis and may contribute to the symmetrical spread of inflammation","volume":"26","author":"Kelly","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"39","key":"10.1016\/j.ejim.2009.08.007_bib68","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1021\/bi061180d","article-title":"Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization","volume":"45","author":"Luo","year":"2006","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.ejim.2009.08.007_bib69","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bmc.2007.10.021","article-title":"Profiling protein arginine deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors","volume":"16","author":"Knuckley","year":"2008","journal-title":"Bioorg Med Chem"},{"issue":"14","key":"10.1016\/j.ejim.2009.08.007_bib70","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1073\/pnas.0800578105","article-title":"The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes","volume":"105","author":"Oak","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.ejim.2009.08.007_bib71","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.imlet.2007.09.011","article-title":"Oral administration of type-II collagen suppresses IL-17-associated RANKL expression of CD4+ T cells in collagen-induced arthritis","volume":"117","author":"Ju","year":"2008","journal-title":"Immunol Lett"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620509001654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620509001654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T21:04:15Z","timestamp":1685135055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620509001654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0953620509001654"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2009.08.007","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}