{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:08:13Z","timestamp":1793138893022,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ejim.2010.03.006","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T17:46:45Z","timestamp":1269971205000},"page":"191-195","source":"Crossref","is-referenced-by-count":35,"title":["Obstructive sleep apnoea syndrome and the metabolic syndrome in an internal medicine setting"],"prefix":"10.1016","volume":"21","author":[{"given":"Francesco","family":"Angelico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"del Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Augelletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"de Vita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Roma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Fabiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3Pt 1","key":"10.1016\/j.ejim.2010.03.006_bib1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1164\/ajrccm.163.3.9911064","article-title":"Prevalence of sleep-disordered breathing in women","volume":"163","author":"Bixler","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"9657","key":"10.1016\/j.ejim.2010.03.006_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(08)61622-0","article-title":"Obstructive sleep apnoea and its cardiovascular consequences","volume":"373","author":"Bradley","year":"2009","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ejim.2010.03.006_bib3","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1183\/09031936.02.00306502","article-title":"Mortality in severe sleep apnoea\/hypopnoea syndrome patients: impact of treatment","volume":"20","author":"Marti","year":"2002","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.ejim.2010.03.006_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.numecd.2006.12.005","article-title":"Obstructive sleep apnea: an update on mechanisms and cardiovascular consequences","volume":"17","author":"Wolf","year":"2007","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"9464","key":"10.1016\/j.ejim.2010.03.006_bib5","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)74229-X","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea\u2013hypopnoea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.ejim.2010.03.006_bib6","first-page":"1079","article-title":"Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study","volume":"31","author":"Marshall","year":"2008","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.ejim.2010.03.006_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome \u2014 a new world-wide definition. A consensus statement from the International Diabetes Federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabet Med"},{"issue":"19","key":"10.1016\/j.ejim.2010.03.006_bib8","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"issue":"17","key":"10.1016\/j.ejim.2010.03.006_bib9","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ejim.2010.03.006_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.smrv.2005.01.006","article-title":"Sleep apnea is a manifestation of the metabolic syndrome","volume":"9","author":"Vgontzas","year":"2005","journal-title":"Sleep Med Rev"},{"issue":"19","key":"10.1016\/j.ejim.2010.03.006_bib11","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","article-title":"Prospective study of the association between sleep-disordered breathing and hypertension","volume":"342","author":"Peppard","year":"2000","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ejim.2010.03.006_bib12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1183\/09031936.01.17407280","article-title":"Angiotensin converting enzyme in patients with sleep apnoea syndrome: plasma activity and gene polymorphisms","volume":"17","author":"Barcelo","year":"2001","journal-title":"Eur Respir J"},{"issue":"9","key":"10.1016\/j.ejim.2010.03.006_bib13","first-page":"527","article-title":"Is obstructive sleep apnea a common cause of essential hypertension?","volume":"31","author":"Silverberg","year":"1995","journal-title":"Isr J Med Sci"},{"issue":"8","key":"10.1016\/j.ejim.2010.03.006_bib14","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.rmed.2007.02.025","article-title":"The association of OSA with insulin resistance, inflammation and the metabolic syndrome","volume":"101","author":"Peled","year":"2007","journal-title":"Resp Med"},{"issue":"11","key":"10.1016\/j.ejim.2010.03.006_bib15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/thx.2007.093740","article-title":"Insulin resistance and daytime sleepiness in patients with sleep apnoea","volume":"63","author":"Barcel\u00f2","year":"2008","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.ejim.2010.03.006_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2265.2005.02407.x","article-title":"Obstructive sleep apnoea syndrome, plasma adiponectin levels and insulin resistance","volume":"64","author":"Makino","year":"2006","journal-title":"Clin Endocrinol"},{"issue":"3","key":"10.1016\/j.ejim.2010.03.006_bib17","article-title":"Insulin resistance and other metabolic aspects of the obstructive sleep apnea syndrome","volume":"11","author":"Harsh","year":"2005","journal-title":"Med Sci Monit"},{"issue":"5","key":"10.1016\/j.ejim.2010.03.006_bib18","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.165.5.2103001","article-title":"Obstructive sleep apnea is independently associated with insulin resistance","volume":"165","author":"Ip","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.ejim.2010.03.006_bib19","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.06-1807","article-title":"Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome","volume":"131","author":"Kono","year":"2007","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.ejim.2010.03.006_bib20","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1478-3231.2008.01822.x","article-title":"Apnoeic\u2013hypopnoeic episodes during obstructive sleep apnoea are associated with histological nonalcoholic steatohepatitis","volume":"28","author":"Mishra","year":"2008","journal-title":"Liver Int"},{"issue":"Supp 1","key":"10.1016\/j.ejim.2010.03.006_bib21","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.2337\/diacare.28.suppl_1.S37","article-title":"Diagnosis and classification of diabetes mellitus","volume":"28","author":"American Diabetes Association","year":"2005","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.ejim.2010.03.006_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"issue":"7","key":"10.1016\/j.ejim.2010.03.006_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentration in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.ejim.2010.03.006_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.5664\/jcsm.26910","article-title":"Relationship of metabolic syndrome and obstructive sleep apnea","volume":"3","author":"Parish","year":"2007","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.ejim.2010.03.006_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1475-2840-5-22","article-title":"Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state","volume":"5","author":"Gruber","year":"2006","journal-title":"Cardiovasc Diabetol"},{"issue":"14","key":"10.1016\/j.ejim.2010.03.006_bib26","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.283.14.1829","article-title":"Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study","volume":"283","author":"Nieto","year":"2000","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.ejim.2010.03.006_bib27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/sleep\/16.6.539","article-title":"Effect of nasal continuous positive airway pressure during sleep on 24-hour blood pressure in obstructive sleep apnea","volume":"16","author":"Wilcox","year":"1993","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.ejim.2010.03.006_bib28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/sleep\/16.6.545","article-title":"Long-term nasal continuous positive airway pressure administration can normalize hypertension in obstructive sleep apnea patients","volume":"16","author":"Suzuki","year":"1993","journal-title":"Sleep"},{"issue":"Suppl. 2","key":"10.1016\/j.ejim.2010.03.006_bib29","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.2337\/dc08-s272","article-title":"Abdominal fat and sleep apnea","volume":"31","author":"Pillar","year":"2008","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.ejim.2010.03.006_bib30","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.2337\/dc07-2003","article-title":"Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight\/obese individuals","volume":"31","author":"Seicean","year":"2008","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.ejim.2010.03.006_bib31","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.rmed.2006.11.024","article-title":"Does metabolic syndrome cause obstructive sleep apnoea?","volume":"101","author":"Chang","year":"2007","journal-title":"Respir Med"},{"issue":"12","key":"10.1016\/j.ejim.2010.03.006_bib32","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1164\/rccm.200504-637OC","article-title":"Association of sleep apnea and type II diabetes: a population-based study","volume":"172","author":"Reichmuth","year":"2005","journal-title":"Am J Respir Crit Care Med"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362051000049X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362051000049X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T11:18:25Z","timestamp":1591183105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095362051000049X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S095362051000049X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2010.03.006","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}