{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:28:44Z","timestamp":1762176524056},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.ejim.2011.06.004","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T15:06:36Z","timestamp":1310655996000},"page":"179-184","source":"Crossref","is-referenced-by-count":10,"title":["Effects of renin\u2013angiotensin blockers\/inhibitors and statins on mortality and functional impairment in polypathological patients"],"prefix":"10.1016","volume":"23","author":[{"given":"Javier","family":"Galindo-Oca\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ximo","family":"Bernabeu-Wittel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Formiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Fuertes-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosco","family":"Bar\u00f3n-Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Murcia-Zaragoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Moreno-Gavi\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Ollero-Baturone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2011.06.004_bb0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jacc.2007.06.063","article-title":"Statins for secondary prevention in elderly patients: a hierarchical Bayesian meta-analysis","volume":"51","author":"Afilalo","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2011.06.004_bb0010","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/hrt.2005.061523","article-title":"Effect of statins on the mortality of patients with ischaemic heart disease: population based cohort study with nested case\u2013control analysis","volume":"92","author":"Hippisley-Cox","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.ejim.2011.06.004_bb0015","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/CIRCULATIONAHA.105.591446","article-title":"Statins and mortality among elderly patients hospitalized with heart failure","volume":"113","author":"Foody","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2011.06.004_bb0020","first-page":"115-700-7","article-title":"Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease","author":"Deedwania","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2011.06.004_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-147-1-200707030-00002","article-title":"Outcomes of using high- or low-dose atorvastatin in patients 65years of age or older with stable coronary heart disease","volume":"147","author":"Wenger","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejim.2011.06.004_bb0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/eurheartj\/ehi115","article-title":"Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)","volume":"26","author":"Flather","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2011.06.004_bb0035","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1093\/eurheartj\/ehl250","article-title":"The perindopril in elderly people with chronic heart failure (PEP-CHF) study","volume":"27","author":"Cleland","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2011.06.004_bb0040","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0140-6736(99)12323-7","article-title":"Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE study","volume":"355","author":"Heart Outcomes Prevention Evaluation (HOPE) Study Investigators","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ejim.2011.06.004_bb0045","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0002-9149(03)00833-6","article-title":"Effect of simvastatin versus placebo on treadmill exercise time until the onset of intermittent claudication in older patients with peripheral artery disease at six months and at one year after treatment","volume":"92","author":"Aronow","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ejim.2011.06.004_bb0050","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1056\/NEJMsb042458","article-title":"Potential pitfalls of disease-specific guidelines for patients with multiple conditions","volume":"351","author":"Tinetti","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2011.06.004_bb0055","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/MCA.0b013e32833ce07c","article-title":"Age and sex differences, and changing trends, in the use of evidence-based therapies in acute coronary syndromes: perspectives from a multinational registry","volume":"21","author":"Nguyen","year":"2010","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.ejim.2011.06.004_bb0060","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jacc.2005.05.084","article-title":"Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes","volume":"46","author":"Alexander","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2011.06.004_bb0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.archger.2009.10.006","article-title":"Peeking through the cracks: an assessment of the prevalence, clinical characteristics and health-related quality of life (HRQoL) of people with polypathology in a hospital setting","volume":"51","author":"Bernabeu-Wittel","year":"2010","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.ejim.2011.06.004_bb0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1157\/13076399","article-title":"Incidence and clinical features of patients with comorbidity attended in internal medicine areas","volume":"125","author":"Garc\u00eda-Morillo","year":"2005","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.ejim.2011.06.004_bb0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1157\/13115000","article-title":"Clinical, functional, mental and sociofamiliar features in polypathological patients. One-year prospective study in Primary Health Care","volume":"208","author":"Ram\u00edrez-Duque","year":"2008","journal-title":"Rev Clin Esp"},{"key":"10.1016\/j.ejim.2011.06.004_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1157\/13098491","article-title":"Risk factors associated to mortality and functional deterioration in pluripathological patients with heart failure","volume":"207","author":"Garc\u00eda-Morillo","year":"2007","journal-title":"Rev Clin Esp"},{"key":"10.1016\/j.ejim.2011.06.004_bb0085","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.rce.2009.12.008","article-title":"Drug-drug interactions in multicentre polypathological polymedicated patients","volume":"210","author":"Galindo-Oca\u00f1a","year":"2010","journal-title":"Rev Clin Esp"},{"key":"10.1016\/j.ejim.2011.06.004_bb0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.rce.2009.11.015","article-title":"Disability as a barrier to drug adherence in polypathological patients: role of main carer","volume":"210","author":"Galindo-Oca\u00f1a","year":"2010","journal-title":"Rev Clin Esp"},{"key":"10.1016\/j.ejim.2011.06.004_bb0095","doi-asserted-by":"crossref","unstructured":"Rinc\u00f3n-G\u00f3mez M, Bernabeu-Wittel M, Boh\u00f3rquez-Colombo P, Moreno-Gavi\u00f1o L, Cassani-Garza M, Ortiz-Cam\u00fa\u00f1ez MA, et al. Perceived quality of healthcare in a multicenter, community-based population of polypathological patients. Arch Gerontol Geriatr. 2011;52:142\u20136","DOI":"10.1016\/j.archger.2010.03.003"},{"key":"10.1016\/j.ejim.2011.06.004_bb0100","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/jama.294.6.716","article-title":"Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases","volume":"294","author":"Boyd","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2011.06.004_bb0105","series-title":"Atenci\u00f3n al paciente pluripatol\u00f3gico. Proceso Asistencial Integrado","author":"Ollero-Baturone","year":"2007"},{"key":"10.1016\/j.ejim.2011.06.004_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2005.08.023","article-title":"ACC\/AHA guidelines for the evaluation and management of chronic heart failure in the adult","volume":"46","author":"Hunt","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2011.06.004_bb0115","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/thx.54.7.581","article-title":"Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease","volume":"54","author":"Bestall","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2011.06.004_bb0120","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejim.2011.06.004_bb0125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.ejim.2011.06.004_bb0130","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ejim.2011.06.004_bb0135","first-page":"61","article-title":"Functional evaluation: the Barthel Index","volume":"4","author":"Mahoney","year":"1965","journal-title":"Md State Med J"},{"key":"10.1016\/j.ejim.2011.06.004_bb0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: self maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.1016\/j.ejim.2011.06.004_bb0145","first-page":"129","article-title":"Spanish language adaptation and validation of the Pfeiffer's questionnaire (SPMSQ) to detect cognitive deterioration in people over 65 years of age","volume":"117","author":"Mart\u00ednez de la Iglesia","year":"2001","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.ejim.2011.06.004_bb0150","first-page":"178","article-title":"La escala sociofamiliar de Gij\u00f3n, elemento \u00fatil en el hospital general","volume":"33","author":"Alarc\u00f3n","year":"1998","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"10.1016\/j.ejim.2011.06.004_bb0155","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCULATIONAHA.107.188209","volume":"117","author":"Antman","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2011.06.004_bb0160","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0195-668X(02)00618-8","article-title":"Management of acute myocardial infarction in patients presenting with ST-segment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology","volume":"24","author":"Van de Werf","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2011.06.004_bb0165","doi-asserted-by":"crossref","unstructured":"Bernabeu-Wittel M, Bar\u00f3n-Franco B, Murcia-Zaragoza J, Fuertes-Mart\u00edn A, Ramos-Cantos C, Fern\u00e1ndez-Moyano A, et al. A multi-institutional, hospital-based assessment of clinical, functional, sociofamilial and health-care characteristics of polypathological patients. Arch Gerontol Geriatr in press; doi:10.1016\/j.archger.2010.12.006.","DOI":"10.1016\/j.archger.2010.12.006"},{"key":"10.1016\/j.ejim.2011.06.004_bb0170","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.medcli.2009.04.056","article-title":"Differences between office and ambulatory control of hypertension in very elderly patients. The CARDIORISC \u2013 MAPAPRES project","volume":"133","author":"Llisterri","year":"2009","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.ejim.2011.06.004_bb0175","doi-asserted-by":"crossref","first-page":"555","DOI":"10.7326\/0003-4819-137-7-200210010-00006","article-title":"Association of renal insufficiency with treatment and outcomes alter myocardial infarction in elderly patients","volume":"137","author":"Shlipak","year":"2002","journal-title":"Ann Intern Med"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620511001142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620511001142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T20:19:12Z","timestamp":1560370752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620511001142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0953620511001142"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2011.06.004","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}