{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:22:50Z","timestamp":1776381770157,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ejim.2012.11.012","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:50:45Z","timestamp":1355359845000},"page":"e30-e34","source":"Crossref","is-referenced-by-count":34,"title":["High prevalence of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia"],"prefix":"10.1016","volume":"24","author":[{"given":"Bernardo","family":"Sope\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. Teresa","family":"P\u00e9rez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Portela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayka","family":"Freire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Mart\u00ednez-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2012.11.012_bb0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/jmg.2009.069013","article-title":"International guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia","volume":"48","author":"Faughnan","year":"2011","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejim.2012.11.012_bb0010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2174\/157016110791330771","article-title":"A review on clinical management and pharmacological therapy on hereditary haemorrhagic telangiectasia (HHT)","volume":"8","author":"Zarrabeitia","year":"2010","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0015","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJM199510053331407","article-title":"Hereditary hemorrhagic telangiectasia","volume":"333","author":"Guttmacher","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2012.11.012_bb0020","first-page":"125","article-title":"Hereditary haemorrhagic telangiectasia: study of hepatic vascular alterations with multi-detector row helical CT and reconstruction programs","volume":"109","author":"Memeo","year":"2005","journal-title":"Radiol Med"},{"key":"10.1016\/j.ejim.2012.11.012_bb0025","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/jmg.40.7.494","article-title":"Visceral manifestations in hereditary haemorrhagic telangiectasia type 2","volume":"40","author":"Abdalla","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejim.2012.11.012_bb0030","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jhep.2006.12.008","article-title":"Liver involvement in hereditary hemorrhagic telangiectasia (HHT)","volume":"46","author":"Garc\u00eda-Tsao","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0035","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/hep.22514","article-title":"Evaluation of previously nonscreened hereditary hemorrhagic telangiectasia patients shows frequent liver involvement and early cardiac consequences","volume":"48","author":"Gincul","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.ejim.2012.11.012_bb0040","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jmg.2005.035451","article-title":"Genotype\u2013phenotype relationship in hereditary haemorrhagic telangiectasia","volume":"43","author":"Letteboer","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejim.2012.11.012_bb0045","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000103205","article-title":"Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (Rendu\u2013Osler disease)","volume":"74","author":"Cottin","year":"2007","journal-title":"Respiration"},{"key":"10.1016\/j.ejim.2012.11.012_bb0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P","article-title":"Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu\u2013Osler\u2013Weber syndrome)","volume":"91","author":"Shovlin","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.ejim.2012.11.012_bb0055","first-page":"1219","volume":"34","author":"Galie","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2012.11.012_bb0060","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1148\/radiol.2301021745","article-title":"Hereditary hemorrhagic telangiectasia: multi-detector row helical CT assessment of hepatic involvement","volume":"230","author":"Ianora","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.ejim.2012.11.012_bb0065","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJM200009283431305","article-title":"Liver disease in patients with hereditary hemorrhagic telangiectasia","volume":"343","author":"Garc\u00eda-Tsao","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2012.11.012_bb0070","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/thx.54.8.714","article-title":"Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms","volume":"54","author":"Shovlin","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2012.11.012_bb0075","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1016\/j.jacc.2004.02.032","article-title":"Diagnosis and differential assessment of pulmonary arterial hypertension","volume":"43","author":"Barst","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0080","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00007890-200107270-00012","article-title":"Liver transplantation for treatment of intrahepatic Osler's disease: first experiences","volume":"72","author":"Pfitzmann","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.ejim.2012.11.012_bb0085","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ijcard.2009.01.035","article-title":"An unusual cause of pulmonary hypertension and refractory edema","volume":"148","author":"Sope\u00f1a","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0090","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1056\/NEJM200108023450503","article-title":"Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia","volume":"345","author":"Trembath","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2012.11.012_bb0095","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/jmg.40.12.865","article-title":"Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia","volume":"40","author":"Harrison","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejim.2012.11.012_bb0100","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jacc.2009.04.012","article-title":"Updated clinical classification of pulmonary hypertension","volume":"54","author":"Simonneau","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2362.2006.01683.x","article-title":"Bosentan therapy for pulmonary arterial hypertension associated with hereditary haemorrhagic telangiectasia","volume":"36","author":"Bonderman","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ejim.2012.11.012_bb0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/01.gim.0000204463.77319.1c","article-title":"Echocardiographic screening discloses increased values of pulmonary artery systolic pressure in 9 of 68 unselected patients affected with hereditary hemorrhagic telangiectasia","volume":"8","author":"Olivieri","year":"2006","journal-title":"Genet Med"},{"key":"10.1016\/j.ejim.2012.11.012_bb0115","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/01.sla.0000247258.35406.a4","article-title":"Liver transplantation for hereditary hemorrhagic telangiectasia: report of the European liver transplant registry","volume":"244","author":"Lerut","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejim.2012.11.012_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0b013e31802f8da1","article-title":"Pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: a series of 126 patients","volume":"86","author":"Cottin","year":"2007","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ejim.2012.11.012_bb0125","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s11605-007-0411-9","article-title":"Treatment of high output cardiac failure by flow-adapted hepatic artery banding (FHAB) in patients with hereditary hemorrhagic telangiectasia","volume":"12","author":"Koscielny","year":"2008","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.ejim.2012.11.012_bb0130","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/lt.21417","article-title":"Bevacizumab reverses need for liver transplantation in hereditary hemorrhagic telangiectasia","volume":"14","author":"Mitchell","year":"2008","journal-title":"Liver Transpl"},{"key":"10.1016\/j.ejim.2012.11.012_bb0135","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1378\/chest.06-2674","article-title":"Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines","volume":"131","author":"Badesch","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2012.11.012_bb0140","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.jacc.2009.04.017","article-title":"Updated evidence-based treatment algorithm in pulmonary arterial hypertension","volume":"54","author":"Barst","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0145","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1183\/09031936.00061308","article-title":"The pulmonary vascular complications of hereditary haemorrhagic telangiectasia","volume":"33","author":"Faughnan","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2012.11.012_bb0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1023\/A:1010604913656","article-title":"Diagnostic value of resting tricuspid regurgitation velocity and right ventricular ejection flow parameters for the detection of exercise induced pulmonary arterial hypertension","volume":"16","author":"Bossone","year":"2000","journal-title":"Int J Card Imaging"},{"key":"10.1016\/j.ejim.2012.11.012_bb0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/rheumatology\/36.2.239","article-title":"Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis","volume":"36","author":"Denton","year":"1997","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0160","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1067\/mob.2001.114857","article-title":"A comparison of echocardiography and pulmonary artery catheterization for evaluation of pulmonary artery pressures in pregnant patients with suspected pulmonary hypertension","volume":"184","author":"Penning","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejim.2012.11.012_bb0165","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1164\/rccm.200811-1691OC","article-title":"Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension","volume":"179","author":"Fisher","year":"2009","journal-title":"Am J Respir Crit Care Med"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620512002993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620512002993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T02:59:15Z","timestamp":1540004355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620512002993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0953620512002993"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2012.11.012","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}