{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:34:07Z","timestamp":1786988047660,"version":"build-2736575974"},"reference-count":85,"publisher":"Elsevier BV","issue":"4","content-domain":{"domain":["ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.ejim.2013.10.001","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T16:02:41Z","timestamp":1383148961000},"page":"320-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Chronic Obstructive Pulmonary Disease in the elderly"],"prefix":"10.1016","volume":"25","author":[{"given":"Raffaele Antonelli","family":"Incalzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Scarlata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Pennazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Santonico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pedone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2013.10.001_bb0005","first-page":"938","article-title":"Chronic obstructive pulmonary disease among adults \u2014 United States","volume":"61","author":"CDC","year":"2012","journal-title":"MMWR"},{"key":"10.1016\/j.ejim.2013.10.001_bb0010","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1055\/s-0028-1105858","article-title":"The prevalence of chronic obstructive pulmonary disease (COPD) in Germany. Results of the BOLD study","volume":"133","author":"Geldmacher","year":"2008","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.ejim.2013.10.001_bb0015","doi-asserted-by":"crossref","first-page":"354S","DOI":"10.1378\/chest.117.5_suppl_2.354S","article-title":"The prevalence of COPD: using smoking rates to estimate disease frequency in the general population","volume":"117","author":"Stang","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0020","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1164\/rccm.201010-1704OC","article-title":"Trends in cause-specific mortality in oxygen-dependent chronic obstructive pulmonary disease","volume":"183","author":"Ekstr\u00f6m","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0025","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1164\/rccm.200809-1398OC","article-title":"Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease","volume":"179","author":"Savale","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0030","first-page":"524","article-title":"Telomere dysfunction, autoimmunity and aging","volume":"2","author":"Hohensinner","year":"2011","journal-title":"Aging and Disease"},{"key":"10.1016\/j.ejim.2013.10.001_bb0035","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2217\/fca.11.55","article-title":"Telomere length in cardiovascular disease: new challenges in measuring this marker of cardiovascular aging","volume":"7","author":"Hoffmann","year":"2011","journal-title":"Future Cardiol"},{"key":"10.1016\/j.ejim.2013.10.001_bb0040","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/CIRCULATIONAHA.109.854299","article-title":"Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity","volume":"120","author":"Spyridopoulos","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2013.10.001_bb0045","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1183\/09031936.02.00050502","article-title":"Copenhagen City Heart Study: longitudinal analysis of ventilatory capacity in diabetic and nondiabetic adults","volume":"20","author":"Lange","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2013.10.001_bb0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1164\/rccm.201106-0992OC","article-title":"Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease","volume":"185","author":"Nishimura","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0055","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1164\/rccm.200901-0127OC","article-title":"Lung volume reference values for women and men 65 to 85years of age","volume":"180","author":"Garcia-Rio","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.resp.2013.03.012","article-title":"The aging respiratory system \u2014 pulmonary structure, function and neural control","volume":"87","author":"Lalley","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.ejim.2013.10.001_bb0065","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1164\/ajrccm\/148.2.418","article-title":"Chronic obstructive pulmonary disease. An original model of cognitive decline","volume":"148","author":"Incalzi","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.ejim.2013.10.001_bb0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/13803390701287390","article-title":"Correlation between cognitive impairment and dependence in hypoxemic COPD","volume":"30","author":"Antonelli-Incalzi","year":"2008","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.ejim.2013.10.001_bb0075","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","article-title":"Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease","volume":"106","author":"Anthonisen","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0080","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1365-2796.2002.01005.x","article-title":"Exacerbated chronic obstructive pulmonary disease: a frequently unrecognized condition","volume":"252","author":"Incalzi","year":"2002","journal-title":"J Intern Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0085","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1183\/09031936.04.00014304","article-title":"Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS\/ERS position paper","volume":"23","author":"Celli","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2013.10.001_bb0090","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1164\/ajrccm.161.4.9810093","article-title":"Quality control of spirometry in the elderly. The SA.R.A. study. SAlute Respiration nell'Anziano=Respiratory Health in the Elderly","volume":"161","author":"Bellia","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0095","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.rmed.2005.04.029","article-title":"Prevalence and underdiagnosis of COPD by disease severity and the attributable fraction of smoking. Report from the Obstructive Lung Disease in Northern Sweden Studies","volume":"100","author":"Lindberg","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2013.10.001_bb0105","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1164\/ajrccm.162.3.9907115","article-title":"FEV(6) is an acceptable surrogate for FVC in the spirometric diagnosis of airway obstruction and restriction","volume":"162","author":"Swanney","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0110","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1053\/rmed.2001.1270","article-title":"The FEV1\/FEV6 predicts lung function decline in adult smokers","volume":"96","author":"Enright","year":"2002","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0115","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1378\/chest.124.5.1805","article-title":"Spirometric reference values for the 6-s FVC maneuver","volume":"124","author":"Hankinson","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1183\/09031936.04.00088403","article-title":"Spirometric reference equations for European females and males aged 65\u201385yrs","volume":"24","author":"Garc\u00eda-R\u00edo","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2013.10.001_bb0125","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/thx.2007.080572","article-title":"Validation of FEV6 in the elderly: correlates of performance and repeatability","volume":"63","author":"Bellia","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2013.10.001_bb0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general U.S. population","volume":"159","author":"Hankinson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0135","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2147\/COPD.S31630","article-title":"Diagnosis of airway obstruction in the elderly: contribution of the SARA study","volume":"7","author":"Sorino","year":"2012","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.ejim.2013.10.001_bb0140","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1152\/japplphysiol.90336.2008b","article-title":"The major limitation to exercise performance in COPD is dynamic hyperinflation","volume":"105","author":"O'Donnell","year":"2008","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ejim.2013.10.001_bb0145","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.rmed.2010.05.017","article-title":"Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD","volume":"104","author":"Berton","year":"2010","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0150","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1164\/rccm.200906-0939OC","article-title":"Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma","volume":"180","author":"Fens","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0155","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.lungcan.2009.11.003","article-title":"An investigation on electronic nose diagnosis of lung cancer","volume":"68","author":"D'Amico","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ejim.2013.10.001_bb0160","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1063\/1.3626340","article-title":"Exhaled breath analysis for the monitoring of elderly COPD patients health-state","volume":"1362","author":"Pennazza","year":"2011","journal-title":"AIP Conference Proceedings"},{"key":"10.1016\/j.ejim.2013.10.001_bb0165","doi-asserted-by":"crossref","first-page":"e45396","DOI":"10.1371\/journal.pone.0045396","article-title":"Reproducibility and respiratory function correlates of exhaled breath fingerprint in chronic obstructive pulmonary disease","volume":"7","author":"Incalzi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejim.2013.10.001_bb0170","first-page":"130","article-title":"Exhaled volatile organic compounds as biomarkers for respiratory diseases","volume":"49","author":"Mazzone","year":"2010","journal-title":"Eur Respir Mon"},{"key":"10.1016\/j.ejim.2013.10.001_bb0175","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jaci.2007.05.043","article-title":"An electronic nose in the discrimination of patients with asthma and controls","volume":"120","author":"Dragonieri","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ejim.2013.10.001_bb0180","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1378\/chest.128.4.2387","article-title":"Exhaled ethane. An in vivo biomarker of lipid peroxidation in interstitial lung diseases","volume":"128","author":"Kanoh","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0185","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1128\/JCM.01591-05","article-title":"Prospects for clinical application of electronic-nose technology to early detection of Mycobacterium tuberculosis in culture and sputum","volume":"44","author":"Fend","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ejim.2013.10.001_bb0190","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-925X-1-4","article-title":"Bacteria classification using Cyranose 320 electronic nose","volume":"1","author":"Dutta","year":"2002","journal-title":"Biomed Eng Online"},{"key":"10.1016\/j.ejim.2013.10.001_bb0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2362.2010.02376.x","article-title":"Electronic nose analysis of bronchoalveolar lavage fluid","volume":"41","author":"Humphreys","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0200","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1378\/chest.123.4.1066","article-title":"Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study","volume":"123","author":"Bellia","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200906-0896OC","article-title":"Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program","volume":"181","author":"Moore","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0210","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1183\/09031936.03.00101203","article-title":"Do GOLD stages of COPD severity really correspond to differences in health status?","volume":"22","author":"Antonelli-Incalzi","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2013.10.001_bb0215","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/ajrccm.164.3.2004029","article-title":"The health impact of undiagnosed airflow obstruction in a national sample of United States adults","volume":"164","author":"Coultas","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0220","series-title":"European respiratory society monograph","first-page":"35","article-title":"Multidimensional assessment and treatment of the elderly with COPD","volume":"43","author":"Antonelli Incalzi","year":"2009"},{"key":"10.1016\/j.ejim.2013.10.001_bb0225","first-page":"49","article-title":"Gruppo Italiano di Farmacovigilanza (Italian Group for Pharmacological Survey in the Elderly). Predicting length of stay of older patients with exacerbated chronic obstructive pulmonary disease","volume":"13","author":"Incalzi","year":"2001","journal-title":"Aging (Milano)"},{"key":"10.1016\/j.ejim.2013.10.001_bb0230","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1001\/archinte.167.1.60","article-title":"Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life","volume":"167","author":"Ng","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0235","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1164\/ajrccm.164.5.2012122","article-title":"Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease","volume":"164","author":"O'Donnell","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0240","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1183\/09059180.00002610","article-title":"Impact of exacerbations on COPD","volume":"19","author":"Anzueto","year":"2010","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.ejim.2013.10.001_bb0245","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/1471-2458-7-227","article-title":"Socioeconomic status and hospitalization in the very old: a retrospective study","volume":"7","author":"Antonelli-Incalzi","year":"2007","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ejim.2013.10.001_bb0250","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1378\/chest.127.3.830","article-title":"Construct validity of activities of daily living scale: a clue to distinguish the disabling effects of COPD and congestive heart failure","volume":"127","author":"Incalzi","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0255","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1164\/arrd.1986.133.1.14","article-title":"Prognosis in chronic obstructive pulmonary disease","volume":"133","author":"Anthonisen","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.ejim.2013.10.001_bb0260","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJMoa063070","article-title":"Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease","volume":"356","author":"Calverley","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0265","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1056\/NEJMoa0805800","article-title":"A 4-year trial of tiotropium in chronic obstructive pulmonary disease","volume":"359","author":"Tashkin","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0275","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa021322","article-title":"The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease","volume":"350","author":"Celli","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0280","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1183\/09031936.00008812","article-title":"Alternative ways of expressing FEV1 and mortality in an elderly population with and without COPD","volume":"41","author":"Pedone","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2013.10.001_bb0285","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1164\/rccm.201105-0831OC","article-title":"The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort","volume":"184","author":"Casanova","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0290","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1183\/09031936.97.10122794","article-title":"Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease","volume":"10","author":"Antonelli Incalzi","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2013.10.001_bb0295","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1161\/01.CIR.99.12.1600","article-title":"Electrocardiographic signs of chronic cor pulmonale: a negative prognostic finding in chronic obstructive pulmonary disease","volume":"99","author":"Incalzi","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2013.10.001_bb0300","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1378\/chest.130.6.1687","article-title":"Drawing impairment predicts mortality in severe COPD","volume":"130","author":"Antonelli-Incalzi","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0305","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1378\/chest.130.6.1636","article-title":"Double jeopardy","volume":"130","author":"Royall","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0310","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0002-9343(99)80374-X","article-title":"Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease","volume":"98","author":"Fuso","year":"1995","journal-title":"Am J Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0315","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJMoa1008378","article-title":"Tiotropium versus salmeterol for the prevention of exacerbations of COPD","volume":"364","author":"Vogelmeier","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0320","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1368-5031.2006.00933.x","article-title":"A simple drawing test to identify patients who are unlikely to be able to learn to use an inhaler","volume":"60","author":"Board","year":"2006","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.ejim.2013.10.001_bb0325","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1378\/chest.112.6.1506","article-title":"Verbal memory impairment in COPD: its mechanisms and clinical relevance","volume":"112","author":"Incalzi","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0330","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000117297","article-title":"The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment","volume":"36","author":"Carlesimo","year":"1996","journal-title":"Eur Neurol"},{"key":"10.1016\/j.ejim.2013.10.001_bb0335","series-title":"Examen clinique en psychologie","author":"Rey","year":"1964"},{"key":"10.1016\/j.ejim.2013.10.001_bb0340","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/01.JGP.0000199381.98971.d1","article-title":"Outcomes of depressed patients undergoing inpatient pulmonary rehabilitation","volume":"14","author":"Alexopoulos","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.ejim.2013.10.001_bb0345","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.rmed.2007.04.007","article-title":"Seven-year time course of lung function, symptoms, health-related quality of life, and exercise tolerance in COPD patients undergoing pulmonary rehabilitation programs","volume":"101","author":"Foglio","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0350","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1378\/chest.128.3.1194","article-title":"Can individualized rehabilitation improve functional independence in elderly patients with COPD?","volume":"128","author":"Sewell","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0355","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/j.rmed.2007.07.016","article-title":"Efficacy of pulmonary rehabilitation in chronic respiratory failure (CRF) due to chronic obstructive pulmonary disease (COPD): the Maugeri study","volume":"101","author":"Carone","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0360","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/ageing\/afn126","article-title":"Age does not hamper the response to pulmonary rehabilitation of COPD patients","volume":"37","author":"Di Meo","year":"2008","journal-title":"Age Ageing"},{"key":"10.1016\/j.ejim.2013.10.001_bb0365","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/157339807780599162","article-title":"Clinical and prognostic implications of cognitive dysfunction and depression in COPD","volume":"3","author":"Corsonello","year":"2007","journal-title":"Current Respiratory Medicine Reviews"},{"key":"10.1016\/j.ejim.2013.10.001_bb0370","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-7525-5-17","article-title":"Palliative care provision for patients with chronic obstructive pulmonary disease","volume":"5","author":"Yohannes","year":"2007","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.ejim.2013.10.001_bb0375","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/jpm.2012.0285","article-title":"Implementing a palliative care trial in advanced COPD: a feasibility assessment (the COPD IMPACT study)","volume":"16","author":"Horton","year":"2013","journal-title":"J Palliat Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0380","series-title":"European respiratory society monograph","first-page":"327","article-title":"Palliative and end-of-life care for patients with respiratory disease","volume":"43","author":"Halpin","year":"2009"},{"key":"10.1016\/j.ejim.2013.10.001_bb0385","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1378\/chest.09-1710","article-title":"Chronic renal failure: a neglected comorbidity of COPD","volume":"137","author":"Incalzi","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0390","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.rmed.2009.12.012","article-title":"The MRC dyspnoea scale by telephone interview to monitor health status in elderly COPD patients","volume":"104","author":"Paladini","year":"2010","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0395","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1345\/aph.1D113","article-title":"Use of beta-blockers in patients with COPD","volume":"38","author":"Andrus","year":"2004","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.ejim.2013.10.001_bb0400","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s001980050063","article-title":"Reduced pulmonary function in patients with spinal osteoporotic fractures","volume":"8","author":"Schlaich","year":"1998","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ejim.2013.10.001_bb0405","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/j.1532-5415.2006.00924.x","article-title":"Clinical characteristics of obstructive sleep apnea in community-dwelling older adults","volume":"54","author":"Endeshaw","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.ejim.2013.10.001_bb0410","doi-asserted-by":"crossref","DOI":"10.1111\/resp.12070","article-title":"Nutritional support and functional capacity in chronic obstructive pulmonary disease: a systematic review and meta-analysis","author":"Collins","year":"2013","journal-title":"Respirology"},{"key":"10.1016\/j.ejim.2013.10.001_bb0420","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1056\/NEJM199406233302501","article-title":"Exercise training and nutritional supplementation for physical frailty in very elderly people","volume":"330","author":"Fiatarone","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2013.10.001_bb0425","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1378\/chest.11-1690","article-title":"Physician specialty as a source of heterogeneity in the care of patients with COPD","volume":"140","author":"Paladini","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2013.10.001_bb0435","first-page":"217","article-title":"Comorbidities in current COPD guidelines","volume":"59","author":"Bakke","year":"2013","journal-title":"Eur Respir Mon"},{"key":"10.1016\/j.ejim.2013.10.001_bb0440","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1378\/chest.123.3.784","article-title":"Costs of chronic bronchitis and COPD: a 1-year follow-up study","volume":"123","author":"Miravitlles","year":"2003","journal-title":"Chest"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620513009746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620513009746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T03:23:07Z","timestamp":1539228187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620513009746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0953620513009746"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2013.10.001","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic Obstructive Pulmonary Disease in the elderly","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2013.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}