{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:28:58Z","timestamp":1782955738355,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ejinme.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.ejim.2015.04.023","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T19:02:12Z","timestamp":1432839732000},"page":"515-520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prognostic role of atrial fibrillation in patients affected by chronic heart failure. Data from the MECKI score research group"],"prefix":"10.1016","volume":"26","author":[{"given":"Stefania","family":"Paolillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piergiuseppe","family":"Agostoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Masarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Corr\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Passino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Scrutinio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Correale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Cattadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Girola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo F.","family":"Piepoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Salvioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Giovannardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Raimondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariantonietta","family":"Cicoira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romualdo","family":"Belardinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Guazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Clemenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela B.","family":"Scardovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Di Lenarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"La Gioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Frigerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pacileo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Perrone-Filardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Limongelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2015.04.023_bb0005","doi-asserted-by":"crossref","first-page":"2D","DOI":"10.1016\/S0002-9149(02)03373-8","article-title":"Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy","volume":"91","author":"Maisel","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ejim.2015.04.023_bb0010","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2009.01.055","article-title":"Atrial fibrillation and heart failure in cardiology practice: reciprocal impact and combined management from the perspective of atrial fibrillation: results of the Euro Heart Survey on atrial fibrillation","volume":"53","author":"Nieuwlaat","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2015.04.023_bb0015","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1093\/eurheartj\/ehi505","article-title":"European Heart Survey investigators. Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on atrial fibrillation","volume":"26","author":"Nieuwlaat","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2015.04.023_bb0020","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0195-668X(02)00823-0","volume":"24","author":"Cleland","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2015.04.023_bb0025","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1161\/01.CIR.0000072767.89944.6E","article-title":"Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study","volume":"107","author":"Wang","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2015.04.023_bb0030","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/eurjhf\/hfp085","article-title":"A meta-analysis of the prognostic significance of atrial fibrillation in chronic heart failure","volume":"11","author":"Mamas","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1445-5994.2009.01991.x","article-title":"Atrial fibrillation and the risk of death in patients with heart failure: a literature-based meta-analysis","volume":"40","author":"Wasywich","year":"2010","journal-title":"Intern Med J"},{"key":"10.1016\/j.ejim.2015.04.023_bb0040","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2015.04.023_bb0045","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/CIRCHEARTFAILURE.111.962688","article-title":"Atrial fibrillation and mortality in heart failure: a community study","volume":"4","author":"Chamberlain","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0050","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIRCHEARTFAILURE.111.965681","article-title":"Presence of atrial fibrillation is independently associated with adverse outcomes in patients hospitalized with heart failure: an analysis of get with the guidelines-heart failure","volume":"5","author":"Mountantonakis","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0055","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/eurjhf\/hfq052","article-title":"EchoCardiography and Heart Outcome Study investigators. Atrial fibrillation in heart failure is associated with an increased risk of death only in patients with ischaemic heart disease","volume":"12","author":"Rauns\u00f8","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0060","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/eurjhf\/hfr066","article-title":"Clinical and prognostic effects of atrial fibrillation in heart failure patients with reduced and preserved left ventricular ejection fraction","volume":"13","author":"Linssen","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0065","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1253\/circj.CJ-09-0316","volume":"73","author":"Hamaguchi","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.ejim.2015.04.023_bb0070","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/j.ijcard.2012.06.113","article-title":"MECKI score research group. Metabolic exercise test data combined with cardiac and kidney indexes, the MECKI score: a multiparametric approach to heart failure prognosis","volume":"167","author":"Agostoni","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2015.04.023_bb0075","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1093\/eurheartj\/ehn361","article-title":"Permanent atrial fibrillation affects exercise capacity in chronic heart failure patients","volume":"29","author":"Agostoni","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2015.04.023_bb0080","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1161\/CIRCHEARTFAILURE.113.000471","article-title":"MECKI score research group. Prognostic value of indeterminable anaerobic threshold in heart failure","volume":"6","author":"Agostoni","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0085","series-title":"Principles of exercise testing and interpretation including pathophysiology and clinical applications","first-page":"138","article-title":"Clinical exercise testing","author":"Wasserman","year":"2005"},{"key":"10.1016\/j.ejim.2015.04.023_bb0090","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ejheart.2004.06.007","article-title":"Work-rate affects cardiopulmonary exercise test results in heart failure","volume":"7","author":"Agostoni","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0095","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0735-1097(98)00297-6","article-title":"Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials","volume":"32","author":"Dries","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2015.04.023_bb0100","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.jacc.2006.01.060","volume":"47","author":"Olsson","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2015.04.023_bb0105","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/eurheartj\/ehi166","article-title":"Prognostic relevance of atrial fibrillation in patients with chronic heart failure on long-term treatment with betablockers: results from COMET","volume":"26","author":"Swedberg","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2015.04.023_bb0110","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejheart.2006.08.004","article-title":"Prevalence and prognostic significance of atrial fibrillation in outpatients with heart failure due to left ventricular systolic dysfunction","volume":"9","author":"Corell","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2015.04.023_bb0115","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/hrt.78.6.564","article-title":"Atrial fibrillation is associated with a lower exercise capacity in male chronic heart failure patients","volume":"78","author":"Pardaens","year":"1997","journal-title":"Heart"},{"key":"10.1016\/j.ejim.2015.04.023_bb0120","first-page":"VI102","article-title":"The influence of atrial fibrillation on prognosis in mild to moderate heart failure. The V-HeFT studies. The V-HeFT VA cooperative studies group","volume":"87","author":"Carson","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2015.04.023_bb0125","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/clc.20939","article-title":"No impact of atrial fibrillation on mortality risk in optimally treated heart failure patients","volume":"34","author":"Tveit","year":"2011","journal-title":"Clin Cardiol"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620515001454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620515001454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T04:53:23Z","timestamp":1537592003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620515001454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0953620515001454"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2015.04.023","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic role of atrial fibrillation in patients affected by chronic heart failure. Data from the MECKI score research group","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2015.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}