{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:24:57Z","timestamp":1789878297620,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Novartis Pharmaceuticals"}],"content-domain":{"domain":["ejinme.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ejim.2015.10.003","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T12:31:10Z","timestamp":1447158670000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Development of a new disease severity scoring system for patients with non-transfusion-dependent thalassemia"],"prefix":"10.1016","volume":"28","author":[{"given":"M. Domenica","family":"Cappellini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled M.","family":"Musallam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Kattamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vip","family":"Viprakasit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Galanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali T.","family":"Taher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2015.10.003_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/GIM.0b013e3181cd68ed","article-title":"Beta-thalassemia","volume":"12","author":"Cao","year":"2010","journal-title":"Genet Med"},{"key":"10.1016\/j.ejim.2015.10.003_bb0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1172-5-13","article-title":"Alpha-thalassaemia","volume":"5","author":"Harteveld","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.ejim.2015.10.003_bb0015","first-page":"339","article-title":"Alpha and beta thalassemia","volume":"80","author":"Muncie","year":"2009","journal-title":"Am Fam Physician"},{"issue":"Suppl. 1","key":"10.1016\/j.ejim.2015.10.003_bb0020","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/S0268-960X(12)70010-3","article-title":"Advances in the treatment of alpha-thalassemia","volume":"26","author":"Vichinsky","year":"2012","journal-title":"Blood Rev"},{"key":"10.1016\/j.ejim.2015.10.003_bb0025","first-page":"58","article-title":"Thalassemia intermedia","volume":"80","author":"Camaschella","year":"1995","journal-title":"Haematologica"},{"issue":"Suppl. 1","key":"10.1016\/j.ejim.2015.10.003_bb0030","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S0268-960X(12)70004-8","article-title":"Recent advances in the molecular understanding of non-transfusion-dependent thalassemia","volume":"26","author":"Galanello","year":"2012","journal-title":"Blood Rev"},{"issue":"Suppl. 1","key":"10.1016\/j.ejim.2015.10.003_bb0035","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0268-960X(12)70003-6","article-title":"The definition and epidemiology of non-transfusion-dependent thalassemia","volume":"26","author":"Weatherall","year":"2012","journal-title":"Blood Rev"},{"key":"10.1016\/j.ejim.2015.10.003_bb0040","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/pbc.21883","article-title":"Newborn screening for hemoglobinopathies in California","volume":"52","author":"Michlitsch","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejim.2015.10.003_bb0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1172-5-11","article-title":"Beta-thalassemia","volume":"5","author":"Galanello","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.ejim.2015.10.003_bb0050","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1056\/NEJMoa1010174","article-title":"Heterogeneity of hemoglobin H disease in childhood","volume":"364","author":"Lal","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2015.10.003_bb0055","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00277-009-0743-5","article-title":"Clinical features and molecular analysis in Thai patients with HbH disease","volume":"88","author":"Laosombat","year":"2009","journal-title":"Ann Hematol"},{"key":"10.1016\/j.ejim.2015.10.003_bb0060","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1182\/asheducation-2007.1.79","article-title":"Hemoglobin E syndromes","author":"Vichinsky","year":"2007","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"10.1016\/j.ejim.2015.10.003_bb0065","first-page":"704","article-title":"Inherited haemoglobin disorders: an increasing global health problem","volume":"79","author":"Weatherall","year":"2001","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.ejim.2015.10.003_bb0070","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a013482","article-title":"\u03b2-thalassemia intermedia: a clinical perspective","volume":"2","author":"Musallam","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ejim.2015.10.003_bb0075","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3324\/haematol.2012.066845","article-title":"Non-transfusion-dependent thalassemias","volume":"98","author":"Musallam","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.ejim.2015.10.003_bb0080","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1365-2141.2010.08486.x","article-title":"Optimal management of \u03b2-thalassaemia intermedia","volume":"152","author":"Taher","year":"2011","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejim.2015.10.003_bb0085","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bcmd.2011.07.005","article-title":"Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with beta thalassemia intermedia","volume":"47","author":"Musallam","year":"2011","journal-title":"Blood Cells Mol Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.ejim.2015.10.003_bb0090","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/S0268-960X(12)70007-3","article-title":"Hypercoagulability in non-transfusion-dependent thalassemia","volume":"26","author":"Cappellini","year":"2012","journal-title":"Blood Rev"},{"key":"10.1016\/j.ejim.2015.10.003_bb0095","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2141.2000.02376.x","article-title":"Venous thromboembolism and hypercoagulability in splenectomized patients with thalassaemia intermedia","volume":"111","author":"Cappellini","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejim.2015.10.003_bb0100","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1160\/TH06-05-0267","article-title":"Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran","volume":"96","author":"Taher","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ejim.2015.10.003_bb0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1378\/chest.107.1.50","article-title":"Pulmonary hypertension and right heart failure in patients with \u03b2-thalassemia intermedia","volume":"107","author":"Aessopos","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2015.10.003_bb0110","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1182\/blood.V97.11.3411","article-title":"Cardiac involvement in thalassemia intermedia: a multicenter study","volume":"97","author":"Aessopos","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.ejim.2015.10.003_bb0115","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2141.2010.08220.x","article-title":"Age-related complications in treatment-na\u00efve patients with thalassaemia intermedia","volume":"150","author":"Taher","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejim.2015.10.003_bb0120","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3324\/haematol.2011.047852","article-title":"Elevated liver iron concentration is a marker of increased morbidity in patients with \u03b2-thalassemia intermedia","volume":"96","author":"Musallam","year":"2011","journal-title":"Haematologica"},{"issue":"Suppl. 1","key":"10.1016\/j.ejim.2015.10.003_bb0125","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/S0268-960X(12)70006-1","article-title":"Iron overload in non-transfusion-dependent thalassemia: a clinical perspective","volume":"26","author":"Musallam","year":"2012","journal-title":"Blood Rev"},{"key":"10.1016\/j.ejim.2015.10.003_bb0130","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1365-2141.2009.07848.x","article-title":"Iron overload in thalassaemia intermedia: reassessment of iron chelation strategies","volume":"147","author":"Taher","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejim.2015.10.003_bb0135","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3324\/haematol.12379","article-title":"A new severity score index for phenotypic classification and evaluation of responses to treatment in type I Gaucher disease","volume":"93","author":"Di Rocco","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.ejim.2015.10.003_bb0140","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/acr.21649","article-title":"Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice","volume":"64","author":"Anderson","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.ejim.2015.10.003_bb0145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/jmedgenet-2011-100407","article-title":"Fabry International Prognostic Index: a predictive severity score for Anderson\u2013Fabry disease","volume":"49","author":"Hughes","year":"2012","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejim.2015.10.003_bb0150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/GIM.0b013e3181c39194","article-title":"A validated disease severity scoring system for adults with type 1 Gaucher disease","volume":"12","author":"Weinreb","year":"2010","journal-title":"Genet Med"},{"key":"10.1016\/j.ejim.2015.10.003_bb0155","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF02723137","article-title":"Phenotype score to grade the severity of thalassemia intermedia","volume":"70","author":"Phadke","year":"2003","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ejim.2015.10.003_bb0160","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ajh.21130","article-title":"A scoring system for the classification of beta-thalassemia\/Hb E disease severity","volume":"83","author":"Sripichai","year":"2008","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ejim.2015.10.003_bb0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bcmd.2013.01.015","article-title":"Evaluation of the 5mg\/g liver iron concentration threshold and its association with morbidity in patients with beta-thalassemia intermedia","volume":"51","author":"Musallam","year":"2013","journal-title":"Blood Cells Mol Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.ejim.2015.10.003_bb0170","article-title":"Serum ferritin for predicting clinically relevant LIC thresholds to guide management of patients with non-transfusion-dependent thalassemia treated with deferasirox: THALASSA study extension analysis","volume":"98","author":"Taher","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.ejim.2015.10.003_bb0175","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bcmd.2013.05.001","article-title":"End stage renal disease in six patients with beta-thalassemia intermedia","volume":"51","author":"Mallat","year":"2013","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.ejim.2015.10.003_bb0180","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.113.002124","article-title":"Prevalence and risk factors for pulmonary arterial hypertension in a large group of beta-thalassemia patients using right heart catheterization: a Webthal(R) study","volume":"129","author":"Derchi","year":"2013","journal-title":"Circulation"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620515003325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620515003325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T10:26:51Z","timestamp":1718188011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620515003325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":36,"alternative-id":["S0953620515003325"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2015.10.003","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a new disease severity scoring system for patients with non-transfusion-dependent thalassemia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2015.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}