{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:37:40Z","timestamp":1790005060210,"version":"4.0.1"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy","award":["22714\/24\/6.10.2011"],"award-info":[{"award-number":["22714\/24\/6.10.2011"]}]}],"content-domain":{"domain":["ejinme.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ejim.2016.06.018","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T09:30:47Z","timestamp":1466847047000},"page":"e38-e39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["High levels of serum homocysteine in non-alcoholic steatohepatitis"],"prefix":"10.1016","volume":"35","author":[{"given":"Nicoleta V.","family":"Leach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Dronca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena C.","family":"Craciun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Crisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejim.2016.06.018_bb0005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejim.2015.01.015","article-title":"Circulating homocysteine in non-alcoholic fatty liver disease","volume":"26","author":"Polyzos","year":"2015","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ejim.2016.06.018_bb0010","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ejim.2014.09.007","article-title":"Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis","volume":"25","author":"Leach","year":"2014","journal-title":"Eur J Intern Med"},{"issue":"1","key":"10.1016\/j.ejim.2016.06.018_bb0015","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3164\/jcbn.15-54","article-title":"Association of homocysteine level with biopsy-proven non-alcoholic fatty liver disease: a meta-analysis","volume":"58","author":"Dai","year":"2016","journal-title":"J Clin Biochem Nutr"},{"issue":"1","key":"10.1016\/j.ejim.2016.06.018_bb0020","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1665-2681(19)31488-7","article-title":"Serum homocysteine levels in patients with non-alcoholic fatty liver disease","volume":"11","author":"Polyzos","year":"2012","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.ejim.2016.06.018_bb0025","doi-asserted-by":"crossref","first-page":"21202","DOI":"10.3390\/ijms151121202","article-title":"Plasma levels of homocysteine and cysteine increased in pediatric NAFLD and strongly correlated with severity of liver damage","volume":"15","author":"Pastore","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.ejim.2016.06.018_bb0030","doi-asserted-by":"crossref","first-page":"e0136822","DOI":"10.1371\/journal.pone.0136822","article-title":"Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced non-alcoholic fatty liver disease","volume":"10","author":"Pacana","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ejim.2016.06.018_bb0035","doi-asserted-by":"crossref","first-page":"E272","DOI":"10.1152\/ajpendo.00351.2003","article-title":"Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor","volume":"286","author":"Davis","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ejim.2016.06.018_bb0040","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3109\/1354750X.2013.838305","article-title":"A novel non-invasive index for non-alcoholic steatohepatitis: a pilot study","volume":"18","author":"Polyzos","year":"2013","journal-title":"Biomarkers"},{"issue":"4","key":"10.1016\/j.ejim.2016.06.018_bb0045","first-page":"174","article-title":"Evaluation of metabolic syndrome in patients with non-alcoholic steatohepatitis","volume":"6","author":"Leach","year":"2014","journal-title":"HVM Bioflux"},{"key":"10.1016\/j.ejim.2016.06.018_bb0050","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-511X-10-60","article-title":"High fat diet-induced non-alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway","volume":"10","author":"Bravo","year":"2011","journal-title":"Lipids Health Dis"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362051630187X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362051630187X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T01:40:30Z","timestamp":1568079630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095362051630187X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":10,"alternative-id":["S095362051630187X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2016.06.018","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High levels of serum homocysteine in non-alcoholic steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2016.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}