{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:10:52Z","timestamp":1791447052872,"version":"4.3.3"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Horten Research Foundation"}],"content-domain":{"domain":["ejinme.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ejim.2018.06.005","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T03:51:47Z","timestamp":1528861907000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Is the clinical presentation of chronic heart failure different in elderly versus younger patients and those with preserved versus reduced ejection fraction?"],"prefix":"10.1016","volume":"57","author":[{"given":"Eva","family":"Steinmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Brunner-La Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha T.","family":"Maeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat A.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Pfisterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rickenbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2018.06.005_bb0005","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0010","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10741-006-9481-0","article-title":"Diagnosis of heart failure in primary care","volume":"11","author":"Fonseca","year":"2006","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.ejim.2018.06.005_bb0020","series-title":"Chronic heart failure: The management of chronic heart failure in adults in primary and secondary care","author":"Centre","year":"2010"},{"key":"10.1016\/j.ejim.2018.06.005_bb0025","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/qjmed\/90.5.335","article-title":"Assessing diagnosis in heart failure: which features are any use?","volume":"90","author":"Davie","year":"1997","journal-title":"QJM"},{"key":"10.1016\/j.ejim.2018.06.005_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta13320","article-title":"Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care","volume":"13","author":"Mant","year":"2009","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.ejim.2018.06.005_bb0035","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1161\/CIRCULATIONAHA.111.019216","article-title":"The diagnostic value of physical examination and additional testing in primary care patients with suspected heart failure","volume":"124","author":"Kelder","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2018.06.005_bb0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ejhf.216","article-title":"Efficiently screening heart failure in patients with type 2 diabetes","volume":"17","author":"Boonman-De Winter","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0045","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/eurjhf\/hfr036","article-title":"Heart failure diagnosis and prognosis in the elderly: the proof of the pudding is in the eating","volume":"13","author":"Filippatos","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0050","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ejhf.110","article-title":"Prevalence of unrecognized heart failure in older persons with shortness of breath on exertion","volume":"16","author":"Vanriet","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0055","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/eurjhf\/hfr021","article-title":"Clinical evaluation of geriatric outpatients with suspected heart failure: value of symptoms, signs, and additional tests","volume":"13","author":"Oudejans","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0060","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2013.05.072","article-title":"Clinical characteristics and outcomes of young and very young adults with heart failure: the CHARM programme (candesartan in heart failure assessment of reduction in mortality and morbidity)","volume":"62","author":"Wong","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0065","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/eurheartj\/ehu216","article-title":"Heart failure in younger patients: the meta-analysis global Group in Chronic Heart Failure (MAGGIC)","volume":"35","author":"Wong","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2018.06.005_bb0070","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ahj.2005.10.022","article-title":"Management of elderly patients with congestive heart failure \u2013 design of the trial of intensified vs standard medical therapy in elderly patients with congestive heart failure (TIME-CHF)","volume":"151","author":"Brunner-La Rocca","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.ejim.2018.06.005_bb0075","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/jama.2009.2","article-title":"BNP-guided vs symptom-guided heart failure therapy - the trial of intensified vs standard medical therapy in elderly patients with congestive heart failure (TIME-CHF randomized trial)","volume":"301","author":"Pfisterer","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2018.06.005_bb0080","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/eurjhf\/hft076","article-title":"N-terminal pro brain natriuretic peptide-guided management in patients with heart failure and preserved ejection fraction: -findings from the trial of intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME-CHF)","volume":"15","author":"Maeder","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0085","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/j.1532-5415.2009.02407.x","article-title":"Clinical features, treatment practices, and hospital and long-term outcomes of older patients hospitalized with decompensated heart failure: the Worcester heart failure study","volume":"57","author":"Saczynski","year":"2009","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.ejim.2018.06.005_bb0090","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/ejhf.330","article-title":"Clinical presentation and outcome by age categories in acute heart failure: results from an international observational cohort","volume":"17","author":"Teixeira","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1067\/mhj.2002.119608","article-title":"Clinical features and outcomes of elderly outpatients with heart failure followed up in hospital cardiology units: data from a large nationwide cardiology database (IN-CHF registry)","volume":"143","author":"Pulignano","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.ejim.2018.06.005_bb0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijcard.2004.03.072","article-title":"Heart failure in the elderly: age-related differences in clinical profile and mortality","volume":"102","author":"Martinez-Selles","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0105","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.ehj.2004.06.006","article-title":"Differences between patients with preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey","volume":"25","author":"Lenzen","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2018.06.005_bb0110","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMoa052256","article-title":"Trends in prevalence and outcome of heart failure with preserved ejection fraction","volume":"355","author":"Owan","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2018.06.005_bb0115","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1001\/jama.296.18.2209","article-title":"Systolic and diastolic heart failure in the community","volume":"296","author":"Bursi","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2018.06.005_bb0120","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJMoa051530","article-title":"Outcome of heart failure with preserved ejection fraction in a population-based study","volume":"355","author":"Bhatia","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2018.06.005_bb0125","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jacc.2005.09.022","article-title":"Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the acute decompensated heart failure National Registry (ADHERE) database","volume":"47","author":"Yancy","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0130","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jacc.2007.04.064","article-title":"Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF registry","volume":"50","author":"Fonarow","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0135","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1161\/CIRCULATIONAHA.108.815944","article-title":"Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the Framingham heart study of the national heart, lung, and blood institute","volume":"119","author":"Lee","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2018.06.005_bb0140","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0002-9343(00)00601-X","article-title":"Systolic versus diastolic heart failure in community practice: clinical features, outcomes and the use of angiotensin-converting enzyme inhibitors","volume":"109","author":"Philbin","year":"2000","journal-title":"Am J Med"},{"key":"10.1016\/j.ejim.2018.06.005_bb0145","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jacc.2003.07.046","article-title":"Heart failure with preserved left ventricular systolic function","volume":"43","author":"Hogg","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0150","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.amjmed.2014.08.024","article-title":"Multimorbidity in heart failure: a community perspective","volume":"128","author":"Chamberlain","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.ejim.2018.06.005_bb0155","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.jacc.2014.08.036","article-title":"Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction","volume":"64","author":"Mentz","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0160","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1388-9842(03)00052-7","article-title":"Clinical features and contemporary management of patients with low and preserved ejection fraction heart failure - assessment of reduction in mortality and morbidity (CHARM) programme","volume":"5","author":"Mcmurray","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0165","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0002-9343(02)01048-3","article-title":"Utility of history, physiocal examination, electrocardiogram, and chest radiograph for differentiating normal from decreased systolic function in patients with heart failure","volume":"112","author":"Thomas","year":"2002","journal-title":"Am J Med"},{"key":"10.1016\/j.ejim.2018.06.005_bb0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.amjcard.2010.08.044","article-title":"Clinical characteristics and predictors of in-hospital mortality in acute heart failure with preserved left ventricular ejection fraction","volume":"107","author":"Parissis","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0175","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ijcard.2015.09.114","article-title":"Clinical epidemiology of heart failure with preserved ejection fration (HFpEF) in comparatively young hospitalized patients","volume":"202","author":"Zaccharias","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2018.06.005_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/ehf2.12283","article-title":"Characteristics and long-term prognosis of patients with heart failure and mid-range ejection fraction","author":"Lauritsen","year":"2018","journal-title":"ESC Heart Failure"},{"key":"10.1016\/j.ejim.2018.06.005_bb0185","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/ejhf.798","article-title":"Heart failure with mid-range ejection fraction: a distinct clinical entity? Insights from the trial of intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME-CHF)","volume":"19","author":"Rickenbacher","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ejim.2018.06.005_bb0190","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/hc1102.105289","article-title":"New concepts in diastolic dysfunction and diastolic heart failure: part I. Diagnosis, prognosis, and measurements of diastolic function","volume":"105","author":"Zile","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2018.06.005_bb0195","article-title":"Predicting heart failure with preserved and reduced ejection fraction","volume":"9","author":"Ho","year":"2016","journal-title":"The international collaboration on heart failure subtypes Circ Heart Fail"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620518302371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620518302371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T18:14:39Z","timestamp":1542046479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620518302371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":39,"alternative-id":["S0953620518302371"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2018.06.005","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is the clinical presentation of chronic heart failure different in elderly versus younger patients and those with preserved versus reduced ejection fraction?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2018.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}