{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:44:48Z","timestamp":1769118288189,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["17K18085"],"award-info":[{"award-number":["17K18085"]}]},{"name":"JSPS KAKENHI","award":["18K15860"],"award-info":[{"award-number":["18K15860"]}]},{"name":"Scientific Research","award":["23591062"],"award-info":[{"award-number":["23591062"]}]},{"name":"Scientific Research","award":["26461088"],"award-info":[{"award-number":["26461088"]}]},{"name":"Scientific Research","award":["16H05215"],"award-info":[{"award-number":["16H05215"]}]},{"name":"Scientific Research","award":["16KK0186"],"award-info":[{"award-number":["16KK0186"]}]},{"name":"Scientific Research","award":["17K09526"],"award-info":[{"award-number":["17K09526"]}]},{"name":"Health Labour Sciences Research","award":["14528506"],"award-info":[{"award-number":["14528506"]}]},{"name":"Sakakibara Clinical Research"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["201439013C"],"award-info":[{"award-number":["201439013C"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ejinme.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ejim.2019.01.014","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T22:00:24Z","timestamp":1549404024000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Association of renin-angiotensin system inhibitors with long-term outcomes in patients with systolic heart failure and moderate-to-severe kidney function impairment"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-8256","authenticated-orcid":false,"given":"Satoshi","family":"Higuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Kohsaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiomi","family":"Katsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nagatomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumori","family":"Sujino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Goda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2019.01.014_bb0005","first-page":"e391","volume":"119","author":"Hunt","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.01.014_bb0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1053\/j.ajkd.2006.10.014","article-title":"Antihypertensive therapy in the presence of proteinuria","volume":"49","author":"Sarafidis","year":"2007","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.ejim.2019.01.014_bb0015","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1157\/13073895","article-title":"Long-term trends in drug prescription for hospitalized patients with congestive heart failure. Influence of type of dysfunction","volume":"58","author":"Grigorian Shamagian","year":"2005","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.ejim.2019.01.014_bb0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11255-007-9299-2","article-title":"Late-onset renal failure from angiotensin blockade (LORFFAB) in 100 CKD patients","volume":"40","author":"Onuigbo","year":"2008","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.ejim.2019.01.014_bb0025","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1093\/ndt\/gfp511","article-title":"The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney disease","volume":"25","author":"Ahmed","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ejim.2019.01.014_bb0030","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.105.582320","article-title":"Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III","volume":"112","author":"Willenheimer","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.01.014_bb0035","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(03)14282-1","article-title":"Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme","volume":"362","author":"Pfeffer","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejim.2019.01.014_bb0040","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J."},{"key":"10.1016\/j.ejim.2019.01.014_bb0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ahj.2015.10.008","article-title":"Validation of the get with the guideline-heart failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide level","volume":"171","author":"Shiraishi","year":"2016","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejim.2019.01.014_bb0050","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/01.CIR.88.1.107","article-title":"Survival after the onset of congestive heart failure in Framingham Heart Study subjects","volume":"88","author":"Ho","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.01.014_bb0055","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa020265","article-title":"Long-term trends in the incidence of and survival with heart failure","volume":"347","author":"Levy","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejim.2019.01.014_bb0060","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ejhf.519","article-title":"Outcomes in patients hospitalized for heart failure and chronic obstructive pulmonary disease: differences in clinical profile and treatment between 2002 and 2009","volume":"18","author":"Staszewsky","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ejim.2019.01.014_bb0065","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/eurjhf\/hfp085","article-title":"Meta-analysis of the prognostic significance of atrial fibrillation in chronic heart failure","volume":"11","author":"Mamas","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ejim.2019.01.014_bb0070","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1253\/circj.CJ-11-1196","article-title":"Loop diuretic use at discharge is associated with adverse outcomes in hospitalized patients with heart failure: a report from the Japanese cardiac registry of heart failure in cardiology (JCARE-CARD)","volume":"76","author":"Hamaguchi","year":"2012","journal-title":"Circ. J."},{"key":"10.1016\/j.ejim.2019.01.014_bb0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa043399","article-title":"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure","volume":"352","author":"Bardy","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejim.2019.01.014_bb0080","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1001\/jama.297.22.2502","article-title":"Cardiac resynchronization therapy for patients with left ventricular systolic dysfunction: a systematic review","volume":"297","author":"McAlister","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2019.01.014_bb0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.amjmed.2011.10.013","article-title":"Renin-angiotensin inhibition in systolic heart failure and chronic kidney disease","volume":"125","author":"Ahmed","year":"2012","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejim.2019.01.014_bb0090","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/eurheartj\/ehv268","article-title":"Association between renin-angiotensin system antagonist use and mortality in heart failure with severe renal insufficiency: a prospective propensity score-matched cohort study","volume":"36","author":"Edner","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejim.2019.01.014_bb0095","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/eurheartj\/ehx026","article-title":"Determinants and clinical outcome of uptitration of ACE-inhibitors and beta-blockers in patients with heart failure: a prospective European study","volume":"38","author":"Ouwerkerk","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejim.2019.01.014_bb0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ehf2.12042","article-title":"Efficacy and safety of supramaximal titrated inhibition of renin-angiotensin-aldosterone system in idiopathic dilated cardiomyopathy","volume":"2","author":"He","year":"2015","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.ejim.2019.01.014_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(18)30306-1","article-title":"Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: a cohort study","volume":"6","author":"Teng","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.ejim.2019.01.014_bb0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000447068","article-title":"Should we stop angiotensin converting enzyme inhibitors\/angiotensin receptor blockers in advanced kidney disease?","volume":"133","author":"Ahmed","year":"2016","journal-title":"Nephron"},{"key":"10.1016\/j.ejim.2019.01.014_bb0115","doi-asserted-by":"crossref","first-page":"F1589","DOI":"10.1152\/ajprenal.00142.2008","article-title":"Disease-dependent mechanisms of albuminuria","volume":"295","author":"Comper","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejim.2019.01.014_bb0120","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1161\/01.CIR.88.5.2277","article-title":"Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) investigators","volume":"88","author":"Konstam","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.01.014_bb0125","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.01.014_bb0130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijcard.2017.01.153","article-title":"The prevalence of frailty in heart failure: a systematic review and meta-analysis","volume":"236","author":"Denfeld","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejim.2019.01.014_bb0135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejim.2015.01.008","article-title":"Sarcopenia evaluated by fat-free mass index is an important prognostic factor in patients with chronic heart failure","volume":"26","author":"Narumi","year":"2015","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ejim.2019.01.014_bb0140","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/ejhf.1252","article-title":"Cancer and heart failure-more than meets the eye: common risk factors and co-morbidities","volume":"20","author":"Anker","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ejim.2019.01.014_bb0145","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1681\/ASN.2006101081","article-title":"Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney disease","volume":"18","author":"Kent","year":"2007","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362051930038X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362051930038X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T16:51:35Z","timestamp":1565196695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095362051930038X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":29,"alternative-id":["S095362051930038X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2019.01.014","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of renin-angiotensin system inhibitors with long-term outcomes in patients with systolic heart failure and moderate-to-severe kidney function impairment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2019.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}