{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:58:49Z","timestamp":1790431129835,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ejinme.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ejim.2019.04.016","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T16:55:57Z","timestamp":1556297757000},"page":"29-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Serum endotrophin levels in patients with heart failure with reduced and mid-range ejection fraction"],"prefix":"10.1016","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-1820","authenticated-orcid":false,"given":"Hasan","family":"Eruzun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lkim Deniz","family":"Toprak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00fccel","family":"Arman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Kutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedat","family":"Irmak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orkide","family":"Kutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eeng\u00fcl Ayd\u0131n","family":"Yoldemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Altun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylem \u00d6zg\u00fcn","family":"\u00c7il","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tufan","family":"T\u00fckek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2019.04.016_bb0005","article-title":"The collgen family","volume":"3","author":"Ricard-Blum","year":"2011","journal-title":"Cold Spring HarbPerspect Biol"},{"key":"10.1016\/j.ejim.2019.04.016_bb0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/path.1395","article-title":"The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis","volume":"200","author":"Heeneman","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.ejim.2019.04.016_bb0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00400687","article-title":"Increased rat myocardial type VI collagen in diabetes mellitus and hypertension","volume":"36","author":"Spiro","year":"1993","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejim.2019.04.016_bb0020","first-page":"325","article-title":"Collagen remodeling and cardiac dysfunction in patients with hypertrophic cardiomyopathy: the significance of type III and VI collagens","volume":"24","author":"Kitamura","year":"2001","journal-title":"ClinCardiol"},{"key":"10.1016\/j.ejim.2019.04.016_bb0025","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1152\/ajpheart.00321.2005","article-title":"Type VI collagen induces cardiac myofbroblastdiferentiation: implications for postinfarctionremodeling","volume":"290","author":"Naugle Jennifer","year":"2006","journal-title":"Am J Physiol Hear CircPhysiol"},{"key":"10.1016\/j.ejim.2019.04.016_bb0030","first-page":"1","article-title":"Serum endotrophin identifies optimal responders to PPAR\u03b3 agonists in type 2 diabetes","author":"Karsdal","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejim.2019.04.016_bb0035","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1038\/ncomms4485","article-title":"Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction","volume":"5","author":"Sun","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.ejim.2019.04.016_bb0040","article-title":"Endotrophin, a multifaceted player in metabolic dysregulation and cancer progression, is a predictive biomarker for the response to PPAR\u03b3 agonist treatment","author":"Sun","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejim.2019.04.016_bb0045","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0733-8651(05)70039-4","article-title":"Ventricular remodeling. Mechanisms and prevention","volume":"16","author":"Goldstein","year":"1998","journal-title":"Cardiol Clin"},{"issue":"1","key":"10.1016\/j.ejim.2019.04.016_bb0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol Rev"},{"issue":"10","key":"10.1016\/j.ejim.2019.04.016_bb0055","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0002-9149(00)00729-3","article-title":"Effect of spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy","volume":"85","author":"Ramires","year":"2000","journal-title":"Am J Cardiol"},{"issue":"14","key":"10.1016\/j.ejim.2019.04.016_bb0060","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/CIRCULATIONAHA.114.013215","article-title":"Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin","volume":"131","author":"Zile","year":"2015","journal-title":"Circulation"},{"issue":"1 Suppl","key":"10.1016\/j.ejim.2019.04.016_bb0065","first-page":"28","article-title":"Neuroendocrine activation after acute myocardial infarction","volume":"65","author":"58-Cohn JN","year":"1990","journal-title":"Am J Cardiol"},{"issue":"4 Suppl","key":"10.1016\/j.ejim.2019.04.016_bb0070","first-page":"90","article-title":"Neurohumoral activation in preclinical hearth failure","volume":"87","author":"Francis","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.04.016_bb0075","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/01.CIR.83.3.1028","article-title":"Contractility and stiffness of noninfarcted myocardium after coronary ligation in rats: effects of chronic angiotensin converting enzyme inhibition","volume":"83","author":"Litwin","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.04.016_bb0080","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/cvr\/28.9.1423","article-title":"Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat","volume":"28","author":"Sun","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ejim.2019.04.016_bb0085","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/0024-3205(82)90441-6","article-title":"Catecholamine mediated constrictor effects of aldosterone on vascular smooth muscle","volume":"30","author":"Weber","year":"1982","journal-title":"Life Sci"},{"key":"10.1016\/j.ejim.2019.04.016_bb0090","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1006\/jmcc.1993.1066","article-title":"Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hypoaldosteronism","volume":"25","author":"Brilla","year":"1993","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ejim.2019.04.016_bb0095","first-page":"250","article-title":"The effect of a mineralocorticoid antagonist on myocardial mIBG uptake in cardiac heart failure","volume":"88","author":"Barr","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.04.016_bb0100","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/cvr\/26.7.671","article-title":"Reactive and reparative myocardial fibrosis in arterial hypertension in the rat","volume":"26","author":"Brilla","year":"1992","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ejim.2019.04.016_bb0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s004410050795","article-title":"Characterization of adult human heart fibroblasts in culture: a comparative study of growth, proliferation and collagen production in human and rabbit cardiac fibroblasts and their response to transforming growth factor-beta1","volume":"288","author":"Agocha","year":"1997","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ejim.2019.04.016_bb0110","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1161\/CIRCRESAHA.111.252734","article-title":"Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction","volume":"110","author":"Luther","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.ejim.2019.04.016_bb0115","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/2047487318758750","article-title":"Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: the iPOWER study","volume":"25","author":"Nielsen","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.ejim.2019.04.016_bb0120","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/emmm.201202006","article-title":"Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours","volume":"5","author":"Park","year":"2013","journal-title":"EMBO Mol Med"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620519301220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620519301220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T11:43:28Z","timestamp":1560339808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620519301220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":24,"alternative-id":["S0953620519301220"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2019.04.016","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum endotrophin levels in patients with heart failure with reduced and mid-range ejection fraction","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2019.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}]}}