{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:15:39Z","timestamp":1760660139628,"version":"build-2065373602"},"reference-count":9,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ejim.2019.11.004","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T11:32:06Z","timestamp":1573731126000},"page":"95-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reviewing thrombotic thrombocytopenic purpura diagnosis and treatment in a Portuguese hospital"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2947-1610","authenticated-orcid":false,"given":"Miguel","family":"Relvas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-8416","authenticated-orcid":false,"given":"Isabel","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-4431","authenticated-orcid":false,"given":"Teresa","family":"Fidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1951-3941","authenticated-orcid":false,"given":"Lu\u00eds","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds","family":"Coentr\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2019.11.004_bib0001","first-page":"4","article-title":"Thrombotic microangiopathies: a general approach to diagnosis and management","volume":"189","author":"Arnold, Donald","year":"2017","journal-title":"CMAJ"},{"key":"10.1016\/j.ejim.2019.11.004_bib0002","article-title":"Role of ADAMTS13 in the management of thrombotic microangiopathies including thrombotic thrombocytopenic purpura (TTP)","volume":"163","author":"Shan","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejim.2019.11.004_bib0003","article-title":"Survival and relapse in patients with thrombotic thrombocytopenic purpura","volume":"115","author":"Kremer Hovinga","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ejim.2019.11.004_bib0004","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/rth2.12016","article-title":"Combined study of ADAMTS13 and complement genes in the diagnosis of thrombotic microangiopathies using next-generation sequencing","author":"Fidalgo","year":"2017","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.ejim.2019.11.004_bib0005","first-page":"1902","article-title":"ADAMTS13 gene mutations influence ADAMTS13 conformation and disease age-onset in the French cohort of Upshaw-Schulman syndrome","volume":"11","author":"Joly","year":"2018","journal-title":"Thromb Haemost 118"},{"key":"10.1016\/j.ejim.2019.11.004_bib0006","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1182\/blood.V120.21.4654.4654","article-title":"International registry for patients with hereditary thrombotic thrombocytopenic purpura (TTP) \u2013 Upshaw-Schulman syndrome","volume":"120","author":"Taleghani","year":"2012","journal-title":"Blood 21"},{"key":"10.1016\/j.ejim.2019.11.004_bib0007","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJMoa1806311","article-title":"Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura","volume":"4","author":"Scully","year":"2019","journal-title":"N Engl J Med 380"},{"issue":"6","key":"10.1016\/j.ejim.2019.11.004_bib0008","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1056\/NEJMoa1505533","article-title":"Caplacizumab for acquired thrombotic thrombocytopenic purpura","volume":"374","author":"Peyvandi","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2019.11.004_bib0009","unstructured":"N.G., James and Cuker, A. Acquired TTP: Initial treatment. UpToDate. [Online] July 2019. [Cited: 22 September2019.] https:\/\/www.uptodate.com\/contents\/acquired-ttp-initial-treatment."}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620519303929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620519303929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:29:12Z","timestamp":1760606952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620519303929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":9,"alternative-id":["S0953620519303929"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2019.11.004","relation":{},"ISSN":["0953-6205"],"issn-type":[{"type":"print","value":"0953-6205"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reviewing thrombotic thrombocytopenic purpura diagnosis and treatment in a Portuguese hospital","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2019.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}]}}