{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:38:36Z","timestamp":1763480316473,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ejim.2019.12.008","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T07:42:42Z","timestamp":1577778162000},"page":"79-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Fibroblast growth factor 23 predicts carotid atherosclerosis in individuals without kidney disease. The CORDIOPREV study"],"prefix":"10.1016","volume":"74","author":[{"given":"Maria E.","family":"Rodr\u00edguez-Ortiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-3611","authenticated-orcid":false,"given":"Juan F.","family":"Alcal\u00e1-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Canalejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 D.","family":"Torres-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"G\u00f3mez-Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan R.","family":"Mu\u00f1oz-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Delgado-Lista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"L\u00f3pez-Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-7348","authenticated-orcid":false,"given":"Yolanda","family":"Almad\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2019.12.008_bib0001","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of FGF23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ejim.2019.12.008_bib0002","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1074\/jbc.C500457200","article-title":"Regulation of fibroblast growth factor-23 signaling by KLOTHO","volume":"281","author":"Kurosu","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejim.2019.12.008_bib0003","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nature05315","article-title":"Klotho converts canonical FGF receptor into a specific receptor for FGF23","volume":"444","author":"Urakawa","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejim.2019.12.008_bib0004","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1681\/ASN.2005010052","article-title":"Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease","volume":"16","author":"Gutierrez","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0005","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.kint.2016.04.024","article-title":"Fibroblast growth factor 23 and markers of mineral metabolism in individuals with preserved renal function","volume":"90","author":"Dhayat","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.ejim.2019.12.008_bib0006","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1681\/ASN.2018020192","article-title":"Genetic variants associated with circulating fibroblast growth factor 23","volume":"29","author":"Robinson-Cohen","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0007","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2019.12.008_bib0008","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.atherosclerosis.2009.01.001","article-title":"Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community","volume":"205","author":"Mirza","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejim.2019.12.008_bib0009","doi-asserted-by":"crossref","first-page":"640","DOI":"10.7326\/0003-4819-152-10-201005180-00004","article-title":"The associations of fibroblast growth factor 23 and uncarboxylated matrix GLA protein with mortality in coronary artery disease: the heart and soul study","volume":"152","author":"Parker","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejim.2019.12.008_bib0010","first-page":"1566","article-title":"Prognostic value of bone- and vascular-derived molecular biomarkers in hemodialysis and renal transplant patients: a systematic review and meta-analysis","volume":"32","author":"Pichler","year":"2017","journal-title":"Nephrol Dial Transp"},{"key":"10.1016\/j.ejim.2019.12.008_bib0011","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1681\/ASN.2017070772","article-title":"Longitudinal FGF23 trajectories and mortality in patients with CKD","volume":"29","author":"Isakova","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0012","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12933-015-0301-5","article-title":"Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis","volume":"14","author":"Biscetti","year":"2015","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.ejim.2019.12.008_bib0013","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/CIRCHEARTFAILURE.113.000952","article-title":"Fibroblast growth factor-23 and cardiovascular disease in the general population: the multi-ethnic study of atherosclerosis","volume":"7","author":"Kestenbaum","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2019.12.008_bib0014","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/joim.12232","article-title":"The fibroblast growth factor-23 and Vitamin D emerge as nontraditional risk factors and may affect cardiovascular risk","volume":"277","author":"Masson","year":"2015","journal-title":"J Intern Med"},{"key":"10.1016\/j.ejim.2019.12.008_bib0015","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1681\/ASN.2018050517","article-title":"Fibroblast growth factor-23 may follow cardiovascular disease rather than causing it in chronic kidney disease","volume":"29","author":"Zhou","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11030175","article-title":"FGF23, biomarker or target?","volume":"11","author":"Rodelo-Haad","year":"2019","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ejim.2019.12.008_bib0017","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1161\/ATVBAHA.115.305945","article-title":"Fibroblast growth factor 23 is associated with carotid plaque presence and area: the Northern Manhattan study","volume":"35","author":"Shah","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0018","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/00004872-200304000-00017","article-title":"Carotid intima-media thickness and carotid and\/or iliofemoral plaques: comparison of two markers of cardiovascular risk in hypertensive patients","volume":"21","author":"Tarti\u00e8re","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.ejim.2019.12.008_bib0019","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1056\/NEJM199901073400103","article-title":"Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. cardiovascular health study collaborative research group","volume":"340","author":"O'Leary","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2019.12.008_bib0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.106.628875","article-title":"Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis","volume":"115","author":"Lorenz","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2019.12.008_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/308190","article-title":"Low magnesium levels and FGF-23 dysregulation predict mitral valve calcification as well as intima media thickness in predialysis diabetic patients","volume":"2015","author":"Silva","year":"2015","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0022","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ahj.2016.04.011","volume":"177","author":"Delgado-Lista","year":"2016","journal-title":"Am Heart J"},{"key":"10.1016\/j.ejim.2019.12.008_bib0023","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.echo.2007.11.011","volume":"21","author":"Stein","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.ejim.2019.12.008_bib0024","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1161\/01.ATV.18.11.1765","article-title":"Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis","volume":"18","author":"Rohde","year":"1988","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0025","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/eurheartj\/ehq185","article-title":"Imaging of atherosclerosis: carotid intima-media thickness","volume":"31","author":"O'Leary","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2019.12.008_bib0026","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ejcn.2010.265","article-title":"Vitamin D deficiency in Spain: a population-based cohort study","volume":"65","author":"Gonz\u00e1lez-Molero","year":"2011","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.ejim.2019.12.008_bib0027","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/mnfr.200900474","article-title":"Vitamin D deficiency and myocardial diseases","volume":"54","author":"Pilz","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.ejim.2019.12.008_bib0028","doi-asserted-by":"crossref","first-page":"F371","DOI":"10.1152\/ajprenal.00740.2010","article-title":"Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4","volume":"301","author":"Gattineni","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0029","doi-asserted-by":"crossref","first-page":"F351","DOI":"10.1152\/ajprenal.00232.2013","article-title":"Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4","volume":"306","author":"Gattineni","year":"2014","journal-title":"Am J Physiol RenalPhysiol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0030","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1093\/ndt\/gfp191","article-title":"High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients","volume":"24","author":"Jean","year":"2009","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.ejim.2019.12.008_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2017.03.042","article-title":"Fibroblast growth factor 23 as a predictor of cardiovascular and all-cause mortality in prospective studies","volume":"261","author":"Qin","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejim.2019.12.008_bib0032","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jacc.2012.03.040","article-title":"Fibroblast growth factor-23 and death, heart failure, and cardiovascular events in community-living individuals: CHS (cardiovascular health study)","volume":"60","author":"Ix","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0033","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2215\/CJN.09570912","article-title":"Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology","volume":"8","author":"\u00c4rnl\u00f6v","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0034","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1365-2265.2007.03074.x","article-title":"Relation between plasma fibroblast growth factor-23, serum fetuin-A levels and coronary artery calcification evaluated by multislice computed tomography in patients with normal kidney function","volume":"68","author":"Roos","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ejim.2019.12.008_bib0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.kint.2018.02.017","article-title":"The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk","volume":"94","author":"Pastor-Arroyo","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.ejim.2019.12.008_bib0036","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1093\/ndt\/gfp205","article-title":"Relationship between circulating FGF23 and total body atherosclerosis in the community","volume":"24","author":"Mirza","year":"2009","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.ejim.2019.12.008_bib0037","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2013.12.015","article-title":"Fibroblast growth factor 23, the ankle-brachial index, and incident peripheral artery disease in the cardiovascular health study","volume":"233","author":"Garimella","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejim.2019.12.008_bib0038","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ejim.2019.12.008_bib0039","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kint.2018.03.024","article-title":"FGF23 effects on the heart-levels, time, source, and context matter","volume":"94","author":"Faul","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.ejim.2019.12.008_bib0040","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.kint.2016.05.019","article-title":"Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease","volume":"90","author":"Singh","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.ejim.2019.12.008_bib0041","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2011.08.850","article-title":"Expression of FGF23\/KLOTHO system in human vascular tissue","volume":"165","author":"Donate-Correa","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0042","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/ki.2013.332","article-title":"Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of KLOTHO deficiency","volume":"85","author":"Jimbo","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.ejim.2019.12.008_bib0043","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1093\/ndt\/gfq089","article-title":"Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients","volume":"25","author":"Nasrallah","year":"2010","journal-title":"Nephrol Dial Transp"},{"key":"10.1016\/j.ejim.2019.12.008_bib0044","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1681\/ASN.2010121224","article-title":"FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis","volume":"22","author":"Kendrick","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0045","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1681\/ASN.2017121334","article-title":"Fibroblast growth factor-23 and risks of cardiovascular and noncardiovascular diseases: a meta-analysis","volume":"29","author":"Marthi","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2019.12.008_bib0046","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/jamacardio.2018.0139","article-title":"Association of fibroblast growth factor 23 with risk of incident coronary heart disease in community-living adults","volume":"3","author":"Panwar","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"3","key":"10.1016\/j.ejim.2019.12.008_bib0047","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000936","article-title":"Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the atherosclerosis risk in communities study","volume":"10","author":"Lutsey","year":"2014","journal-title":"J Am Heart Assoc"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620519304376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620519304376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:31:31Z","timestamp":1760607091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620519304376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":47,"alternative-id":["S0953620519304376"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2019.12.008","relation":{},"ISSN":["0953-6205"],"issn-type":[{"type":"print","value":"0953-6205"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast growth factor 23 predicts carotid atherosclerosis in individuals without kidney disease. The CORDIOPREV study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2019.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}