{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:49:49Z","timestamp":1790743789181,"version":"4.1.0"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ejim.2020.01.011","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:20:40Z","timestamp":1580257240000},"page":"18-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["ANCA associated vasculitis"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4566-5976","authenticated-orcid":false,"given":"Fernando","family":"Salvador","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2020.01.011_bib0001","series-title":"Harrison's principles of internal medicine","first-page":"2119","article-title":"The vasculitis syndromes, 319","author":"Fauci","year":"2008"},{"key":"10.1016\/j.ejim.2020.01.011_bib0002","first-page":"452","volume":"Vol. 1","author":"Willan","year":"1808"},{"key":"10.1016\/j.ejim.2020.01.011_bib0003","first-page":"1","article-title":"Ueber einige der wichtigsten Krankheiten der Arterien. Reproduced from Denkschr Akad der Wissensch","volume":"4","author":"Rokitansky","year":"1852","journal-title":"Wien: Hof-Staatsdruckerei"},{"issue":"Suppl 3","key":"10.1016\/j.ejim.2020.01.011_bib0004","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.3949\/ccjm.79.s3.12","article-title":"History of vasculitis: the life and work of Adolf Kussmaul","volume":"79","author":"Matteson","year":"2012","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.ejim.2020.01.011_bib0005","unstructured":"Groos W.L., Schnabel A., Reinhold-Keller E. Wegener \u0301s. granulomatosis: clinical aspects in: vasculitis, 25. In: Ball GV, Bridges. Oxford. University Press, p. 357\u2013365."},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0006","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0007","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/ajcp\/22.8.777","article-title":"Periarteritis nodosa: a critical review","volume":"22","author":"Zeek","year":"1952","journal-title":"Am J Clin Pathol"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0008","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/art.1780330812","article-title":"The American College of Rheumatology 1990 criteria for the classification of vasculitis","volume":"33","author":"Fries","year":"1990","journal-title":"Summary Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0009","doi-asserted-by":"crossref","first-page":"187e92","DOI":"10.1002\/art.1780370206","article-title":"Nomenclature of systemic vasculitides. Proposal of an international consensus conference","volume":"37","author":"Jennette","year":"1994","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0010","doi-asserted-by":"crossref","first-page":"222e7","DOI":"10.1136\/ard.2006.054593","article-title":"Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies","volume":"66","author":"Watts","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"Revised international Chapel Hill consensus conference nomenclature of vasculitides","volume":"65","author":"Jennette","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejim.2020.01.011_bib0012","unstructured":"DCVAS. Oxford; 2015(accessed in 6 th June 2019). Available in: https:\/\/research.ndorms.ox.ac.uk\/public\/dcvas."},{"issue":"10","key":"10.1016\/j.ejim.2020.01.011_bib0013","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/art.24544","article-title":"Prevalence and incidence of Wegener\u2019s granulomatosis in the UK general practice research database","volume":"61","author":"Watts","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.ejim.2020.01.011_bib0014","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1093\/rheumatology\/kep304","article-title":"Incidence and survival rates in Wegener\u2019s granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa","volume":"48","author":"Mohammad","year":"2009","journal-title":"Rheumatology (Oxford)"},{"issue":"3 Suppl 49","key":"10.1016\/j.ejim.2020.01.011_bib0015","first-page":"S81","article-title":"Incidence of Wegener\u2019s granulomatosis in Finland 1981\u20132000","volume":"26","author":"Takala","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0016","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1445-5994.2008.01672.x","article-title":"Epidemiology of primary systemic vasculitis in the Australian capital territory and south-eastern New South Wales","volume":"38","author":"Ormerod","year":"2008","journal-title":"Intern Med J"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0017","doi-asserted-by":"crossref","first-page":"e6083","DOI":"10.1097\/MD.0000000000006083","article-title":"Clinical characteristics and outcome of Spanish patients with ANCA-associated vasculitides: impact of the vasculitis type, ANCA specificity, and treatment on mortality and morbidity","volume":"96","author":"Solans-Laqu\u00e9","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ejim.2020.01.011_bib0018","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/art.20928","article-title":"Stable incidence of primary systemic vasculitides over five years: results from the German vasculitis register","volume":"53","author":"Reinhold-Keller","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejim.2020.01.011_bib0019","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1055\/s-0031-1279824","article-title":"Epidemiology and etiology of wegener granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and goodpasture syndrome: vasculitides with frequent lung involvement","volume":"32","author":"Gibelin","year":"2011","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2020.01.011_bib0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/art.20077","article-title":"Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener\u2019s granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate","volume":"51","author":"Mahr","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.ejim.2020.01.011_bib0021","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1093\/rheumatology\/kep304","article-title":"Incidence and survival rates in Wegener\u2019s granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa","volume":"48","author":"Mohammad","year":"2009","journal-title":"Rheumatology (Oxford)."},{"issue":"9","key":"10.1016\/j.ejim.2020.01.011_bib0022","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/rheumatology\/kew232","article-title":"Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population","volume":"55","author":"Pearce","year":"2016","journal-title":"Rheumatology (Oxford)"},{"issue":"12","key":"10.1016\/j.ejim.2020.01.011_bib0023","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.40313","article-title":"The epidemiology of antineutrophil cytoplasmic autoantibody\u2013associated vasculitis in Olmsted County, Minnesota","volume":"69","author":"Berti","year":"2017","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0024","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7326\/0003-4819-120-1-199401010-00003","article-title":"Association of chronic nasal carriage of Staphylococcus aureus and higher relapse rates in Wegener granulomatosis","volume":"120","author":"Stegeman","year":"1994","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.ejim.2020.01.011_bib0025","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/rheumatology\/kem022","article-title":"Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener\u2019s granulomatosis","volume":"46","author":"Popa","year":"2007","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0026","doi-asserted-by":"crossref","first-page":"214e23","DOI":"10.1056\/NEJMoa1108735","article-title":"Genetically distinct subsets within ANCA-associated vasculitis","volume":"367","author":"Lyons","year":"2012","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.ejim.2020.01.011_bib0027","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1002\/art.22834","article-title":"HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome","volume":"56","author":"Vaglio","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.ejim.2020.01.011_bib0028","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1002\/art.23496","article-title":"Functionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener\u2019s granulomatosis","volume":"58","author":"Wieczorek","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0029","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/BOR.0000000000000014","article-title":"Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis","volume":"26","author":"Pendergraft","year":"2014","journal-title":"Curr Opin Rheumatol"},{"issue":"12","key":"10.1016\/j.ejim.2020.01.011_bib0030","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.autrev.2013.06.016","article-title":"The association between silica exposure and development of ANCA-associated vasculitis: systematic review and meta-analysis","volume":"12","author":"G\u00f3mez-Puerta","year":"2013","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.ejim.2020.01.011_bib0031","doi-asserted-by":"crossref","unstructured":"Yashiro M., Muso E., Itoh-Ihara T., Oyama A., Hashimoto K., Kawamura T., et\u00a0al. Significantly high regional morbidity of MPO- ANCA-related angitis and\/or nephritis with respiratory tract involvement after the 1995 great earthquake in Kobe (Japan). Am J Kidney Dis2000;35(5):889e95. doi:10.1016\/S0272-6386(00)70260-5.","DOI":"10.1016\/S0272-6386(00)70260-5"},{"issue":"5","key":"10.1016\/j.ejim.2020.01.011_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177482","article-title":"The influence of the Great East Japan earthquake on microscopic polyangiitis: a retrospective observational study","volume":"12","author":"Takeuchi","year":"2017","journal-title":"PLoS ONE"},{"issue":"285","key":"10.1016\/j.ejim.2020.01.011_bib0033","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/bmj.285.6342.606","article-title":"Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?","volume":"4","author":"Davies","year":"1982","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.ejim.2020.01.011_bib0034","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaut.2015.01.003","article-title":"Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by \u201cautoantigen complementarity.\u201d","volume":"59","author":"Reynolds","year":"2015","journal-title":"J Autoimmun"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0035","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrrheum.2014.103","article-title":"Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease","volume":"10","author":"Jennette","year":"2014","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.ejim.2020.01.011_bib0036","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1681\/ASN.2009121238","article-title":"ANCA disease: where is this field heading?","volume":"21","author":"Falk","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0037","series-title":"Vasculites","author":"Noronha","year":"2002"},{"issue":"6","key":"10.1016\/j.ejim.2020.01.011_bib0038","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7326\/0003-4819-116-6-488","article-title":"Wegener granulomatosis: an analysis of 158 patients","volume":"116","author":"Hoffman","year":"1992","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.ejim.2020.01.011_bib0039","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/annrheumdis-2012-201750","article-title":"Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis","volume":"72","author":"Mahr","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0040","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/art.37721","article-title":"Eosinophilic granulomatosis with polyangiitis (Churg\u2010Strauss): clinical characteristics and long\u2010term follow-up of the 383 patients enrolled in the French vasculitis study group cohort","volume":"65","author":"Comarmond","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0041","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00005792-199901000-00003","article-title":"Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients","volume":"78","author":"Guillevin","year":"1999","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ejim.2020.01.011_bib0042","series-title":"Enfermedades autoinmunes sist\u00e9micas","first-page":"162","article-title":"Vasculitis Asociadas a anticuerpos anticitoplasma de neutr\u00f3filo, 12","author":"Hern\u00e1ndez-Rodriguez","year":"2015"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0043","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/j.ajkd.2005.09.022","article-title":"Serial ANCA determinations for monitoring disease activity in patients with ANCA-associated vasculitis: systematic review","volume":"47","author":"Birck","year":"2006","journal-title":"Am J Kidney Dis"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0044","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1136\/annrheumdis-2012-201981","article-title":"Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis","volume":"72","author":"Monach","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0045","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13075-017-1429-3","article-title":"Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis","volume":"19","author":"Ishizaki","year":"2017","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.ejim.2020.01.011_bib0046","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1183\/09031936.97.10122738","article-title":"Efficacy of transbronchial biopsy in pulmonary vaculitides","volume":"10","author":"Schnabel","year":"1997","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0047","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/art.27263","article-title":"Cardiac involvement in Churg-Strauss syndrome","volume":"62","author":"Dennert","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejim.2020.01.011_bib0048","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/ndt\/16.5.953","article-title":"Renal histopathology and clinical course in 94 patients with Wegener\u2019s granulomatosis","volume":"16","author":"Aasar\u00f8d","year":"2001","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0049","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ckj\/sfv012","article-title":"Real-time ultrasound-guided percutaneous renal biopsy with needle guide by nephrologists decreases post-biopsy complications","volume":"8","author":"Prasad","year":"2015","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.ejim.2020.01.011_bib0050","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1681\/ASN.2010050477","article-title":"Histopathologic classification of ANCA-associated glomerulonephritis","volume":"21","author":"Berden","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"10.1016\/j.ejim.2020.01.011_bib0051","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1136\/annrheumdis-2016-209133","article-title":"EULAR\/ERA-EDTA recommendations for the management of ANCA-associated vasculitis","volume":"75","author":"Yates","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0052","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.berh.2009.03.001","article-title":"The diagnosis of vasculitis","volume":"23","author":"Jayne","year":"2009","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0053","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0025-6196(11)63594-5","article-title":"Treatment of antineutrophil cytoplasm autoantibody-associated systemic vasculitis: initiatives of the European community systemic vasculitis clinical trials study group","volume":"72","author":"Jayne","year":"1997","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"10.1016\/j.ejim.2020.01.011_bib0054","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/ard.2006.062711","article-title":"EULAR recommendations for conducting clinical studies and\/ or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis","volume":"66","author":"Hellmich","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.ejim.2020.01.011_bib0055","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/art.21869","article-title":"Solid malignancies among patients in the Wegener\u2019s granulomatosis etanercept trial","volume":"54","author":"Stone","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.ejim.2020.01.011_bib0056","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3899\/jrheum.110276","article-title":"The OMERACT core set of outcome measures for use in clinical trials of ANCA-associated vasculitis","volume":"38","author":"Merkel","year":"2011","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0057","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3899\/jrheum.161139","article-title":"OMERACT endorsement of patient-reported outcome instruments in antineutrophil cytoplasmic antibody\u2212associated vasculitis","volume":"44","author":"Robson","year":"2017","journal-title":"J Rheumatol"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0058","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.berh.2018.10.001","article-title":"Clinical features and structured clinical evaluation of vasculitis","volume":"32","author":"Ponte","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0059","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/art.1780400222","article-title":"Development and initial validation of the vasculitis damage index for the standardized clinical assessment of damage in the systemic vasculitides","volume":"40","author":"Exley","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00005792-199601000-00003","article-title":"Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients","volume":"75","author":"Guillevin","year":"1996","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.1016\/j.ejim.2020.01.011_bib0061","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/ard.2006.062711","article-title":"EULAR recommendations for conducting clinical studies and\/or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis","volume":"66","author":"Hellmich","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.ejim.2020.01.011_bib0062","doi-asserted-by":"crossref","first-page":"670","DOI":"10.7326\/0003-4819-150-10-200905190-00004","article-title":"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial","volume":"150","author":"Groot","year":"2009","journal-title":"Ann Intern Med"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0063","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1002\/art.21142","article-title":"Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis","volume":"52","author":"Groot","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.ejim.2020.01.011_bib0064","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1681\/ASN.2007010090","article-title":"Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis","volume":"18","author":"Jayne","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0065","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa0909169","article-title":"Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis","volume":"363","author":"Jones","year":"2010","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0066","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa0909905","article-title":"Rituximab versus cyclophosphamide for ANCA-associated vasculitis","volume":"363","author":"Stone","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.01.011_bib0067","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1056\/NEJMoa0802311","article-title":"Azathioprine or methotrexate maintenance for ANCA-associated vasculitis","volume":"359","author":"Pagnoux","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.01.011_bib0068","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1001\/jama.2010.1658","article-title":"Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial","volume":"304","author":"Hiemstra","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2020.01.011_bib0069","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1404231","article-title":"Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis","volume":"371","author":"Guillevin","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.01.011_bib0070","first-page":"1","article-title":"Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial","author":"Jones","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2020.01.011_bib0071","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/acr.20176","article-title":"Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis: a meta-analysis","volume":"62","author":"Walsh","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"suppl 10","key":"10.1016\/j.ejim.2020.01.011_bib0072","article-title":"The effects of plasma exchange and reduced-dose glucocorticoids during remission-induction for treatment of severe ANCA-Associated vasculitis [abstract]","volume":"70","author":"Walsh","year":"2018","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0073","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/rheumatology\/kez001","article-title":"A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis","volume":"58","author":"Pepper","year":"2019","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0074","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/art.40137","article-title":"American college of rheumatology guideline for the prevention and treatment of glucocorticoid-induced osteoporosis","volume":"69","author":"Buckley","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0075","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJM197104292841703","article-title":"Cyclophosphamide therapy in Wegener\u2019s granulomatosis","volume":"284","author":"Novack","year":"1971","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.01.011_bib0076","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/ndt\/16.10.2018","article-title":"The value of pulse cyclophosphamide in ANCA-associated vasculitis: meta-analysis and critical review","volume":"16","author":"De Groot","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ejim.2020.01.011_bib0077","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/annrheumdis-2011-200477","article-title":"Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up","volume":"71","author":"Harper","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2020.01.011_bib0078","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/art.22679","article-title":"Churg-Strauss syndrome with poor-prognosis factors: a prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients","volume":"57","author":"Cohen","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.ejim.2020.01.011_bib0079","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.lpm.2013.08.003","article-title":"Rituximab: recommendations of the French vasculitis study group (FVSG) for induction and maintenance treatments of adult, antineutrophil cytoplasm antibody-associated necrotizing vasculitides","volume":"42","author":"Charles","year":"2013","journal-title":"Presse Med"},{"issue":"9","key":"10.1016\/j.ejim.2020.01.011_bib0080","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1002\/art.21263","article-title":"Use of a gonadotropin\u2010releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus","volume":"52","author":"Somers","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.ejim.2020.01.011_bib0081","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1136\/annrheumdis-2017-212878","article-title":"Comparison of individually tailored versus fixed- schedule rituximab regimen to maintain ANCA- associated vasculitis remission: results of a multicentre, randomised controlled, phase III trial (MAINRITSAN2)","volume":"77","author":"Charles","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2020.01.011_bib0082","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13063-017-1857-z","article-title":"Rituximab versus azathioprine as therapy for maintenance of remission for anti- neutrophil cytoplasm antibody-associated vasculitis (RITAZAREM): study protocol for a randomized controlled trial","volume":"18","author":"Gopaluni","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.ejim.2020.01.011_bib0083","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1200\/JCO.2005.05.4684","article-title":"Phase II trial of CHOP plus rituximab in patients with HIV- associated non-Hodgkin\u2019s lymphoma","volume":"24","author":"Bou\u00e9","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0084","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1182\/blood-2005-04-1437","article-title":"Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV- associated non-Hodgkin lymphoma: AIDS\u2013 Malignancies Consortium trial 010","volume":"106","author":"Kaplan","year":"2005","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0085","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection","volume":"67","year":"2017","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.ejim.2020.01.011_bib0086","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/annrheumdis-2017-212588","article-title":"Pneumocystis and glucocorticoid use: to prophylax or not to prophylax (and when?); that is the question","volume":"77","author":"Winthrop","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.ejim.2020.01.011_bib0087","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1002\/art.34547","article-title":"Brief report: long\u2010term outcome of a randomized clinical trial comparing methotrexate to cyclophosphamide for remission induction in early systemic antineutrophil cytoplasmic antibody\u2013associated vasculitis","volume":"64","author":"Faurschou","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejim.2020.01.011_bib0088","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1056\/NEJMoa020286","article-title":"A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies","volume":"349","author":"Jayne","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.01.011_bib0089","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/qjmed\/93.7.433","article-title":"Intravenous immunoglobulin for ANCA\u2010associated systemic vasculitis with persistent disease activity","volume":"93","author":"Jayne","year":"2000","journal-title":"QJM"},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0090","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/art.39472","article-title":"Intravenous immunoglobulin as an immunomodulating agent in antineutrophil cytoplasmic antibody\u2013associated vasculitides: a French nationwide study of ninety\u2010two patients","volume":"68","author":"Crickx","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"10.1016\/j.ejim.2020.01.011_bib0091","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.semarthrit.2013.07.010","article-title":"Biological therapy for systemic vasculitis: a systematic review","volume":"43","author":"Silva-Fern\u00e1ndez","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.ejim.2020.01.011_bib0092","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1093\/ndt\/gfq187","article-title":"Prospective study of TNF\u03b1 blockade with adalimumab in ANCA-associated systemic vasculitis with renal involvement","volume":"25","author":"Laurino","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ejim.2020.01.011_bib0093","doi-asserted-by":"crossref","DOI":"10.1002\/art.40802","article-title":"Efficacy and safety of belimumab and azathioprine for maintenance of remission in ANCA-Associated vasculitis: a randomized controlled study","author":"Jayne","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"10.1016\/j.ejim.2020.01.011_bib0094","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1136\/ard.2007.081661","article-title":"Long-term follow-up of relapsing\/refractory anti-neutrophil cytoplasm antibody associated vasculitis treated with the lymphocyte depleting antibody alemtuzumab (CAMPATH-1H)","volume":"67","author":"Walsh","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0095","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/01.ASN.0000048716.42876.14","article-title":"15-Deoxyspergualin in patients with refractory ANCA-associated systemic vasculitis: a six-month open-label trial to evaluate safety and efficacy","volume":"14","author":"Birck","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.ejim.2020.01.011_bib0096","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/ndt\/gfh763","article-title":"Prolonged treatment of refractory Wegener\u2019s granulomatosis with 15-deoxyspergualin: an open study in seven patients","volume":"20","author":"Schmitt","year":"2005","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"10.1016\/j.ejim.2020.01.011_bib0097","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/ard.2008.092429","article-title":"Deoxyspergualin in relapsing and refractory Wegener\u2019s granulomatosis","volume":"68","author":"Flossmann","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.ejim.2020.01.011_bib0098","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1136\/annrheumdis-2013-204164","article-title":"An open-label trial of abatacept (CTLA4-IG) in non-severe relapsing granulomatosis with polyangiitis (Wegener's)","volume":"73","author":"Langford","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2020.01.011_bib0099","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s10067-017-3752-0","article-title":"Current clinical evidence of tocilizumab for the treatment of ANCA-associated vasculitis: a prospective case serie for microscopic polyangiitis in a combination with corticosteroids and literature review","volume":"36","author":"Sakai","year":"2017","journal-title":"Clin Rheumatol"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0100","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/art.23198","article-title":"Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients","volume":"58","author":"Ribi","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.ejim.2020.01.011_bib0101","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/art.40205","article-title":"Adding azathioprine to remission-induction glucocorticoids for granulomatosis with polyangiitis (Churg-Strauss), microscopic polyangiitis, or polyarteritis nodosa without poor prognosis factors: a randomized","volume":"69","author":"Puechal","year":"2017","journal-title":"Controlled Trial. Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0102","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/1529-0131(200103)44:3<666::AID-ANR116>3.0.CO;2-A","article-title":"Long-term follow-up of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: analysis of four prospective trials including 278 patients","volume":"44","author":"Gayraud","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.ejim.2020.01.011_bib0103","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/art.22679","article-title":"Churg\u2010Strauss syndrome with poor\u2010prognosis factors: a prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty\u2010eight patients","volume":"57","author":"Cohen","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.ejim.2020.01.011_bib0104","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejim.2015.04.022","article-title":"Eosinophilic granulomatosis with polyangiitis (Churg\u2013Strauss) (EGPA) consensus task force recommendations for evaluation and management","volume":"26","author":"Groh","year":"2015","journal-title":"Eur J Intern Med"},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0105","first-page":"198","article-title":"Treatment of glomerulonephritis in microscopic polyangiitis and Churg-Strauss syndrome. Indications of plasma exchanges, meta-analysis of 2 randomized studies on 140 patients, 32 with glomerulonephritis","volume":"148","author":"Guillevin","year":"1997","journal-title":"Ann Med Interne (Paris)"},{"issue":"2","key":"10.1016\/j.ejim.2020.01.011_bib0106","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/annrheumdis-2014-206095","article-title":"Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg\u2013Strauss)","volume":"75","author":"Mohammad","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2020.01.011_bib0107","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1136\/ard.2003.015453","article-title":"Long term effectiveness of intravenous immunoglobulin in Churg-Strauss syndrome","volume":"63","author":"Danieli","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2020.01.011_bib0108","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1081-1206(10)61714-0","article-title":"Treatment of Churg-Strauss syndrome with high-dose intravenous immunoglobulin","volume":"92","author":"Tsurikisawa","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0109","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2133.2003.05807.x","article-title":"C. Churg-Strauss syndrome: successful treatment with mycophenolate mofetil","volume":"150","author":"Assaf","year":"2004","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0110","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1440-1843.2010.01884.x","article-title":"Difficult asthma and Churg-Strauss-like syndrome: a cautionary tale","volume":"16","author":"Lau","year":"2010","journal-title":"Respirology."},{"issue":"6","key":"10.1016\/j.ejim.2020.01.011_bib0111","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3899\/jrheum.160907","article-title":"Interferon-\u03b1 for induction and maintenance of remission in eosinophilic granulomatosis with polyangiitis: a single-centre retrospective observational cohort study","volume":"44","author":"Seeliger","year":"2017","journal-title":"J Rheumatol"},{"issue":"9","key":"10.1016\/j.ejim.2020.01.011_bib0112","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1002\/art.39663","article-title":"Anti\u2010IgE monoclonal antibody (Omalizumab) in refractory and relapsing eosinophilic granulomatosis with polyangiitis (Churg\u2010Strauss): data on seventeen patients","volume":"68","author":"Jachiet","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ejim.2020.01.011_bib0113","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1056\/NEJMoa1702079","article-title":"Mepolizumab or placebo for eosinophilic granulomatosis with polyangiitis","volume":"376","author":"Wechsle","year":"2017","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ejim.2020.01.011_bib0114","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0002-9343(79)90634-X","article-title":"Immunosuppressive and corticosteroid therapy of polyarteritis nodosa","volume":"67","author":"Leib","year":"1979","journal-title":"Am J Med"},{"issue":"3","key":"10.1016\/j.ejim.2020.01.011_bib0115","doi-asserted-by":"crossref","first-page":"488e94","DOI":"10.1136\/ard.2010.137778","article-title":"Long-term patient survival in ANCA-associated vasculitis","volume":"70","author":"Flossmann","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.ejim.2020.01.011_bib0116","doi-asserted-by":"crossref","first-page":"776e84","DOI":"10.1016\/S0272-6386(03)00025-8","article-title":"Outcome of ANCA-associated renal vasculitis: a 5-year retrospective study","volume":"41","author":"Booth","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0117","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/annrheumdis-2013-203927","article-title":"Damage in the anca-associated vasculitides: long-term data from the European vasculitis study group (EUVAS) therapeutic trials","volume":"74","author":"Robson","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ejim.2020.01.011_bib0118","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.berh.2018.07.009","article-title":"The complications of vasculitis and its treatment","volume":"32","author":"King","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"11","key":"10.1016\/j.ejim.2020.01.011_bib0119","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/acr.20276","article-title":"Patient-reported outcome assessment in vasculitis may provide important data and a unique perspective","volume":"62","author":"Herlyn","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362052030011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362052030011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:30:03Z","timestamp":1760607003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095362052030011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":119,"alternative-id":["S095362052030011X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2020.01.011","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ANCA associated vasculitis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2020.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}