{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:10:15Z","timestamp":1785859815568,"version":"3.56.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ejim.2020.03.018","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T16:11:34Z","timestamp":1589731894000},"page":"8-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Chronic cough in adults"],"prefix":"10.1016","volume":"78","author":[{"given":"Antonio","family":"Spanevello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Begh\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Visca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-1689","authenticated-orcid":false,"given":"Leonardo M.","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6924-4500","authenticated-orcid":false,"given":"Alberto","family":"Papi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2020.03.018_bib0001","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pupt.2019.02.002","article-title":"Heterogeneity of cough neurobiology: clinical implications","volume":"55","author":"Mazzone","year":"2019","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ejim.2020.03.018_bib0002","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jaci.2018.09.004","article-title":"Translational review: neuroimmune mechanisms in cough and emerging therapeutic targets","volume":"142","author":"McGovern","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ejim.2020.03.018_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2020.01.042","article-title":"Managing chronic cough as a symptom in children and management algorithms: chest guideline and expert panel report","author":"Chang","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0004","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01136-2019","article-title":"ERS guidelines on the diagnosis and treatment of chronic cough in adults and children","volume":"55","author":"Morice","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2020.03.018_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2019.12.038","article-title":"Chronic cough in individuals with COPD: a population-based cohort study","author":"Landt","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0006","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.rmed.2015.05.020","article-title":"Causes of chronic productive cough: an approach to management","volume":"109","author":"Martin","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0007","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJMra1813799","article-title":"Muco-obstructive lung diseases","volume":"380","author":"Boucher","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0008","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.chest.2017.11.018","article-title":"Cough due to TB and other chronic infections: chest guideline and expert panel report","volume":"153","author":"Field","year":"2018","journal-title":"Chest"},{"issue":"1 Suppl","key":"10.1016\/j.ejim.2020.03.018_bib0009","doi-asserted-by":"crossref","first-page":"197S","DOI":"10.1378\/chest.129.1_suppl.197S","article-title":"Chronic cough due to tuberculosis and other infections: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Rosen","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0010","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02470-2016","article-title":"Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease","volume":"50","author":"Lahousse","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2020.03.018_bib0011","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.jaip.2019.02.021","article-title":"Role and impact of chronic cough in individuals with asthma from the general population","volume":"7","author":"\u00c7olak","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2020.03.018_bib0012","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00101006","article-title":"ERS guidelines on the assessment of cough","volume":"29","author":"Morice","year":"2007","journal-title":"Eur Respir J"},{"issue":"1 suppl","key":"10.1016\/j.ejim.2020.03.018_bib0013","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1378\/chest.129.1_suppl.1S","article-title":"Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Irwin","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0014","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.chest.2017.10.016","article-title":"Classification of cough as a symptom in adults and management algorithms: chest guideline and expert panel report","volume":"153","author":"Irwin","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0015","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4168\/aair.2017.9.5.394","article-title":"Cough hypersensitivity syndrome: a few more steps forward","volume":"9","author":"Song","year":"2017","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.ejim.2020.03.018_bib0016","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.jaip.2019.03.050","article-title":"Management of cough","volume":"7","author":"Gibson","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2020.03.018_bib0017","first-page":"516","article-title":"Recent advances in severe asthma: from phenotypes to personalized medicine","volume":"2020","author":"Schoettler","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0018","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejim.2019.12.032","article-title":"Multimorbidity in COPD, does sleep matter?","volume":"73","author":"Vanfleteren","year":"2020","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0019","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.rmed.2015.03.011","article-title":"Clinical features of the urge-to-cough in patients with chronic cough","volume":"109","author":"Hilton","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0020","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.jaip.2018.04.015","article-title":"Laryngeal dysfunction in cough hypersensitivity syndrome: a cross-sectional observational study","volume":"6","author":"Vertigan","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2020.03.018_bib0021","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/ACI.0000000000000027","article-title":"Mechanisms of cough","volume":"14","author":"Gibson","year":"2014","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.ejim.2020.03.018_bib0022","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ejim.2020.03.018_bib0023","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/resp.12103","article-title":"Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome","volume":"18","author":"Vertigan","year":"2013","journal-title":"Respirology"},{"key":"10.1016\/j.ejim.2020.03.018_bib0024","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1523\/JNEUROSCI.5128-14.2015","article-title":"Distinct brainstem and forebrain circuits receiving tracheal sensory neuron inputs revealed using a novel conditional anterograde transsynaptic viral tracing system","volume":"35","author":"McGovern","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.ejim.2020.03.018_bib0025","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1523\/JNEUROSCI.4597-10.2011","article-title":"Investigation of the neural control of cough and cough suppression in humans using functional brain imaging","volume":"31","author":"Mazzone","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.ejim.2020.03.018_bib0026","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S2213-2600(13)70043-2","article-title":"Chronic cough as a neuropathic disorder","volume":"1","author":"Chung","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0027","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pupt.2015.09.001","article-title":"Neuroimmune interactions in itch: do chronic itch, chronic pain, and chronic cough share similar mechanisms?","volume":"35","author":"Ji","year":"2015","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ejim.2020.03.018_bib0028","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pupt.2017.01.010","article-title":"Central mechanisms of airway sensation and cough hypersensitivity","volume":"47","author":"Driessen","year":"2017","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ejim.2020.03.018_bib0029","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jaci.2015.10.044","article-title":"Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: role of adenosine triphosphate","volume":"138","author":"Bonvini","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.ejim.2020.03.018_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11302-011-9271-6","article-title":"In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization","volume":"8","author":"Ford","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.ejim.2020.03.018_bib0031","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(14)61255-1","article-title":"P2X3 449 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study","volume":"385","author":"Abdulqawi","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ejim.2020.03.018_bib0032","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00439-2019","article-title":"The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study","volume":"54","author":"Morice","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2020.03.018_bib0033","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/thoraxjnl-2015-207425","article-title":"Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control","volume":"71","author":"Ando","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2020.03.018_bib0034","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/rccm.200402-174OC","article-title":"Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough","volume":"170","author":"Groneberg","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0035","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.anai.2011.07.010","article-title":"Neuropeptide levels in nasal secretions from patients with and without chronic cough","volume":"107","author":"Lim","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.ejim.2020.03.018_bib0036","doi-asserted-by":"crossref","first-page":"14037","DOI":"10.1523\/JNEUROSCI.2855-11.2011","article-title":"Vagal afferent stimulation activates astrocytes in the nucleus of the solitary tract via AMPA receptors: evidence of an atypical neural-glial interaction in the brainstem","volume":"31","author":"McDougal","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.ejim.2020.03.018_bib0037","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1056\/NEJMcp1414215","article-title":"Chronic cough","volume":"375","author":"Smith","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0038","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s40136-019-00239-9","article-title":"Therapeutic targets for the treatment of chronic cough","volume":"7","author":"Roe","year":"2019","journal-title":"Curr Otorhinolaryngol Rep"},{"key":"10.1016\/j.ejim.2020.03.018_bib0039","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1742-1241.1998.tb11595.x","article-title":"A retrospective survey of diagnosis and management of patients presenting with chronic cough to a general chest clinic","volume":"52","author":"McGarvey","year":"1998","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.ejim.2020.03.018_bib0040","doi-asserted-by":"crossref","first-page":"977","DOI":"10.7326\/0003-4819-119-10-199311150-00003","article-title":"An algorithmic approach to chronic cough","volume":"119","author":"Pratter","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0041","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/thx.2004.021832","article-title":"Cough. 6: which investigations are most useful in the diagnosis of chronic cough?","volume":"59","author":"McGarvey","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2020.03.018_bib0042","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1378\/chest.116.2.279","article-title":"A pathogenic triad in chronic cough: asthma, postnasal drip syndrome and gastroesophageal reflux disease","volume":"116","author":"Palombini","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0043","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/ajrccm.160.2.9810100","article-title":"Eosinophilic bronchitis is an important cause of chronic cough","volume":"160","author":"Brightling","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0044","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.jaip.2019.03.030","article-title":"An update on speech pathology management of chronic refractory cough","volume":"7","author":"Vertigan","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2020.03.018_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-9974-10-1","article-title":"Development and validation of the Newcastle laryngeal hypersensitivity questionnaire","volume":"10","author":"Vertigan","year":"2014","journal-title":"Cough"},{"key":"10.1016\/j.ejim.2020.03.018_bib0046","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1378\/chest.121.4.1123","article-title":"Evaluation of a cough-specific quality-of-life questionnaire","volume":"121","author":"French","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0047","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thorax.58.4.339","article-title":"Development of a symptom specific health status measure for patients with chronic cough: leicester cough questionnaire (LCQ)","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2020.03.018_bib0048","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1183\/09031936.00057407","article-title":"The leicester cough monitor: preliminary validation of an automated cough detection system in chronic cough","volume":"31","author":"Birring","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2020.03.018_bib0049","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1378\/chest.14-2506","article-title":"Tools for assessing outcomes in studies of chronic cough: chest guideline and expert panel report","volume":"147","author":"Boulet","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0050","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1136\/thx.54.12.1055","article-title":"Can peak expiratory flow measurements reliably identify the presence of obstruction and bronchodilator response as assessed by FEV1 in primary care patients presenting with a persistent cough?","volume":"54","author":"Thiadens","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2020.03.018_bib0051","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1164\/ajrccm.159.6.9809047","article-title":"Exhaled nitric oxide as a noninvasive assessment of chronic cough","volume":"159","author":"Chatkin","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0052","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1183\/09031936.02.00247202","article-title":"Rhinovirus infection in nonasthmatic subjects: effects on intrapulmonary airways","volume":"20","author":"de Kluijver","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2020.03.018_bib0053","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00408-013-9528-7","article-title":"A causal relationship between cough and gastroesophageal reflux disease (GERD) has been established: a pro\/con debate","volume":"192","author":"Kahrilas","year":"2014","journal-title":"Lung"},{"issue":"1 Suppl","key":"10.1016\/j.ejim.2020.03.018_bib0054","doi-asserted-by":"crossref","first-page":"80S","DOI":"10.1378\/chest.129.1_suppl.80S","article-title":"Chronic cough due to gastroesophageal reflux disease: accp evidence-based clinical practice guidelines","volume":"129","author":"Irwin","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0055","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1378\/chest.104.5.1511","article-title":"Chronic cough due to gastroesophageal reflux. Clinical, diagnostic, and pathogenetic aspects","volume":"104","author":"Irwin","year":"1993","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0056","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1136\/thx.53.9.738","article-title":"Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol","volume":"53","author":"McGarvey","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2020.03.018_bib0057","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1745-9974-9-24","article-title":"Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice","volume":"9","author":"Wang","year":"2013","journal-title":"Cough"},{"key":"10.1016\/j.ejim.2020.03.018_bib0058","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1183\/09031936.03.00066403","article-title":"Chronic tonsillar enlargement and cough: preliminary evidence of a novel and treatable cause of chronic cough","volume":"23","author":"Birring","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2020.03.018_bib0059","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11739-018-1960-5","article-title":"The pathogenetic mechanisms of cough in idiopathic pulmonary fibrosis","volume":"14","author":"Bargagli","year":"2019","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0060","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1183\/09031936.00034807","article-title":"Airway abnormalities at flexible bronchoscopy in patients with chronic cough","volume":"30","author":"Decalmer","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2020.03.018_bib0061","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1164\/rccm.200607-892OC","article-title":"Opiate therapy in chronic cough","volume":"175","author":"Morice","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0062","series-title":"Multimorbidity: assessment, prioritisation and management of care for people with commonly occurring multimorbidity","year":"2016"},{"key":"10.1016\/j.ejim.2020.03.018_bib0063","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jaip.2019.04.027","article-title":"Cough: new pharmacology","volume":"7","author":"Smith","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2020.03.018_bib0064","unstructured":"Global Initiative for Asthma (GINA), https:\/\/www.ginasthma.org; 2019[accessed 11 January 2020]."},{"issue":"1 Suppl","key":"10.1016\/j.ejim.2020.03.018_bib0065","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1378\/chest.129.1_suppl.116S","article-title":"Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Brightling","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0066","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJMoa063070","article-title":"Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease","volume":"356","author":"Calverley","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0067","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0140-6736(12)60776-4","article-title":"Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial","volume":"380","author":"Ryan","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ejim.2020.03.018_bib0068","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1378\/chest.15-1271","article-title":"Pregabalin and speech pathology combination therapy for refractory chronic cough: a randomized controlled trial","volume":"149","author":"Vertigan","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0069","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pupt.2009.01.003","article-title":"Central regulation of the cough reflex: therapeutic implications","volume":"22","author":"Canning","year":"2009","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ejim.2020.03.018_bib0070","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.chest.2017.02.001","article-title":"A randomized clinical trial comparing the effects of antitussive agents on respiratory center output in patients with chronic cough","volume":"151","author":"Mannini","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0071","article-title":"Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease","volume":"5","author":"Poole","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejim.2020.03.018_bib0072","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/thx.2006.064337","article-title":"Efficacy of speech pathology management for chronic cough: a randomised placebo controlled trial of treatment efficacy","volume":"61","author":"Vertigan","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.ejim.2020.03.018_bib0073","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.pupt.2013.03.012","article-title":"Cough suppression therapy: does it work?","volume":"26","author":"Chamberlain","year":"2013","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ejim.2020.03.018_bib0074","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.pupt.2017.02.003","article-title":"Advances in mechanisms and management of chronic cough: the ninth London International Cough Symposium 2016","volume":"47","author":"Chung","year":"2017","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ejim.2020.03.018_bib0075","article-title":"Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis","volume":"9","author":"Lee","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejim.2020.03.018_bib0076","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.rmed.2014.11.001","article-title":"Cough reduction using capsaicin","volume":"109","author":"Ternesten-Hass\u00e9us","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0077","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1164\/rccm.201704-0769OC","article-title":"XEN-D0501, a novel transient receptor potential vanilloid 1 antagonist, does not reduce cough in patients with refractory cough","volume":"196","author":"Belvisi","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2020.03.018_bib0078","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pupt.2017.05.004","article-title":"TRPA1 receptors in chronic cough","volume":"47","author":"Morice","year":"2017","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ejim.2020.03.018_bib0079","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2019.11.048","article-title":"Aprepitant for cough suppression in advanced lung cancer: a randomized trial","author":"Noronha","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.ejim.2020.03.018_bib0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pupt.2019.03.006","article-title":"Update on the clinical development of gefapixant, a P2X3 receptor antagonist for the treatment of refractory chronic cough","volume":"56","author":"Muccino","year":"2019","journal-title":"Pulm Pharmacol Ther"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362052030114X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362052030114X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:32:23Z","timestamp":1760607143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095362052030114X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":80,"alternative-id":["S095362052030114X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2020.03.018","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic cough in adults","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2020.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}