{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:34:47Z","timestamp":1769344487171,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ejim.2023.02.002","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T21:53:18Z","timestamp":1675806798000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Functional outcome after cardiac rehabilitation and its association with survival in heart failure across the spectrum of ejection fraction"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-3264","authenticated-orcid":false,"given":"Domenico","family":"Scrutinio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Guida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-5058","authenticated-orcid":false,"given":"Maria Teresa","family":"La Rovere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Bussotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugo","family":"Corr\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-4879","authenticated-orcid":false,"given":"Giovanni","family":"Forni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Raimondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-505X","authenticated-orcid":false,"given":"Simonetta","family":"Scalvini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Passantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2023.02.002_bib0001","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ejim.2023.02.002_bib0002","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2023.02.002_bib0003","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/CIRCHEARTFAILURE.114.001542","article-title":"Activities of daily living and outcomes in heart failure","volume":"8","author":"Dunlay","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0004","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.27410","article-title":"Evaluation of a transitional care program after hospitalization for heart failure in an integrated health care system","volume":"3","author":"Baecker","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ejim.2023.02.002_bib0005","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.15420\/cfr.2022.06","article-title":"Epidemiology and clinical features of heart failure with preserved ejection fraction","volume":"8","author":"Teramoto","year":"2022","journal-title":"Card Fail Rev"},{"key":"10.1016\/j.ejim.2023.02.002_bib0006","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.009462","article-title":"Temporal trends of heart failure hospitalizations in cardiology versus noncardiology wards according to ejection fraction: 16-year data from the SwedeHF Registry","volume":"15","author":"Canepa","year":"2022","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0007","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCRESAHA.119.313572","article-title":"Heart failure with preserved ejection fraction in perspective","volume":"124","author":"Pfeffer","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.ejim.2023.02.002_bib0008","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","article-title":"Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes","volume":"126","author":"Steinberg","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2023.02.002_bib0009","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.jacc.2021.07.014","article-title":"Exercise intolerance in older adults with heart failure with preserved ejection fraction: JACC state-of-the-art review","volume":"78","author":"Pandey","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0010","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jacc.2020.11.022","volume":"77","author":"Maddox","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0011","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.apmr.2021.10.014","article-title":"Characteristics, outcomes, and long-term survival of patients with heart failure undergoing inpatient cardiac rehabilitation","volume":"103","author":"Scrutinio","year":"2021","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.ejim.2023.02.002_bib0012","article-title":"Exercise-based cardiac rehabilitation for adults with heart failure","volume":"1","author":"Long","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejim.2023.02.002_bib0013","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006798","article-title":"Multidisciplinary cardiac rehabilitation and long-term prognosis in patients with heart failure","volume":"13","author":"Kamiya","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0014","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.11686","article-title":"Association of cardiac rehabilitation with all-cause mortality among patients with cardiovascular disease in the Netherlands","volume":"3","author":"Eijsvogels","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ejim.2023.02.002_bib0015","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1177\/2047487319833512","article-title":"Impact of in-hospital cardiac rehabilitation on mortality and readmissions in heart failure: a population study in Lombardy, Italy, from 2005 to 2012","volume":"26","author":"Scalvini","year":"2019","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0016","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/jgs.17736","article-title":"Prognostic value of functional capacity after transitional rehabilitation in older patients hospitalized for heart failure","volume":"70","author":"Scrutinio","year":"2022","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.ejim.2023.02.002_bib0017","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41569-021-00611-7","article-title":"The role of cardiac rehabilitation in improving cardiovascular outcomes","volume":"19","author":"Taylor","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0018","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jchf.2019.04.023","article-title":"Exercise-based rehabilitation for heart failure: cochrane systematic review, meta-analysis, and trial sequential analysis","volume":"7","author":"Taylor","year":"2019","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0019","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jacc.2018.12.072","article-title":"Impact of exercise rehabilitation on exercise capacity and quality-of-life in heart failure: individual participant meta-analysis","volume":"73","author":"Taylor","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS Committee on proficiency standards for clinical pulmonary function laboratories. ATS statement: guidelines for the six-minute walk test","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2023.02.002_bib0021","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.jacc.2016.09.936","article-title":"Natriuretic peptides, 6-min walk test, and quality-of-life questionnaires as clinically meaningful endpoints in HF trials","volume":"68","author":"Ferreira","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0022","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijcard.2017.02.109","article-title":"Reliability, construct validity and determinants of 6-minute walk test performance in patients with chronic heart failure","volume":"240","author":"Uszko-Lencer","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejim.2023.02.002_bib0023","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.2009.454","article-title":"Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial","volume":"301","author":"O'Connor","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2023.02.002_bib0024","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007564","article-title":"Defining a clinically important change in 6- minute walk distance in patients with heart failure and mitral valve disease","volume":"14","author":"Jain","year":"2021","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ejim.2023.02.002_bib0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijcard.2022.01.040","article-title":"Association of improvement in functional capacity after rehabilitation with long-term survival in heart failure","volume":"352","author":"Scrutinio","year":"2022","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0026","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/01823246-201223030-00002","article-title":"Triangulating clinically meaningful change in the six-minute walk test in individuals with chronic heart failure: a systematic review","volume":"23","author":"Shoemaker","year":"2012","journal-title":"Cardiopulm Phys Ther J"},{"key":"10.1016\/j.ejim.2023.02.002_bib0027","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1001\/jama.1993.03510140062030","article-title":"Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. SOLVD Investigators","volume":"270","author":"Bittner","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2023.02.002_bib0028","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0002-8703(98)70219-4","article-title":"Does the 6-minute walk test predict the prognosis in patients with NYHA class II or III chronic heart failure?","volume":"136","author":"Roul","year":"1998","journal-title":"Am Heart J"},{"key":"10.1016\/j.ejim.2023.02.002_bib0029","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ijcard.2018.05.021","article-title":"Factors influencing change in walking ability in patients with heart failure undergoing exercise-based cardiac rehabilitation","volume":"268","author":"Sutherland","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jacc.2006.02.061","article-title":"Short-term change in distance walked in 6 min is an indicator of outcome in patients with chronic heart failure in clinical practice","volume":"48","author":"Passantino","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0031","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jchf.2014.04.006","article-title":"Factors influencing the predictive power of models for predicting mortality and\/or heart failure hospitalization in patients with heart failure","volume":"2","author":"Ouwerkerk","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0032","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jchf.2014.04.008","article-title":"Risk prediction in patients with heart failure: a systematic review and analysis","volume":"2","author":"Rahimi","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0033","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Multicenter InSync randomized clinical evaluation. Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejim.2023.02.002_bib0034","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jchf.2015.01.010","article-title":"Prognostic significance and determinants of the 6-min walk test in patients with heart failure and preserved ejection fraction","volume":"3","author":"Zotter-Tufaro","year":"2015","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0035","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1016\/j.jacc.2012.08.1010","article-title":"6-min walk test provides prognostic utility comparable to cardiopulmonary exercise testing in ambulatory outpatients with systolic heart failure","volume":"60","author":"Forman","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejim.2023.02.002_bib0036","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0002-9149(01)01975-0","article-title":"Prognostic usefulness of the six-minute walk in patients with advanced congestive heart failure secondary to ischemic or nonischemic cardiomyopathy","volume":"88","author":"Shah","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ejim.2023.02.002_bib0037","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.eclinm.2019.06.006","article-title":"Nature of cardiac rehabilitation around the globe","volume":"13","author":"Supervia","year":"2019","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ejim.2023.02.002_bib0038","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/eurheartj\/ehi162","article-title":"Six minute corridor walk test as an outcome measure for the assessment of treatment in randomized, blinded intervention trials of chronic heart failure: a systematic review","volume":"26","author":"Olsson","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2023.02.002_bib0039","doi-asserted-by":"crossref","first-page":"759","DOI":"10.4081\/monaldi.2016.759","article-title":"Exercise training in heart failure patients with preserved ejection fraction: a systematic review and meta-analysis","volume":"86","author":"Chan","year":"2016","journal-title":"Monaldi Arch Chest Dis"},{"key":"10.1016\/j.ejim.2023.02.002_bib0040","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jchf.2021.05.007","article-title":"Rehabilitation intervention in older patients with acute heart failure with preserved versus reduced ejection fraction","volume":"9","author":"Mentz","year":"2021","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0041","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006798","article-title":"Multidisciplinary cardiac rehabilitation and long-term prognosis in patients with heart failure","volume":"13","author":"Kamiya","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0042","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jchf.2019.10.005","article-title":"Frailty is intertwined with heart failure: mechanisms, prevalence, prognosis, assessment, and management","volume":"7","author":"Pandey","year":"2019","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0043","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/ehf2.13885","article-title":"Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction","volume":"9","author":"Hamada","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.ejim.2023.02.002_bib0044","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa2026141","article-title":"Physical rehabilitation for older patients hospitalized for heart failure","volume":"385","author":"Kitzman","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2023.02.002_bib0045","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pcad.2018.08.006","article-title":"Meta-analysis of exercise training on left ventricular ejection fraction in heart failure with reduced ejection fraction: a 10-year Update","volume":"62","author":"Tucker","year":"2019","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.ejim.2023.02.002_bib0046","unstructured":"Piano di indirizzo per la Riabilitazione. Gazzetta Ufficiale della Repubblica Italiana. 2011;50:163\u201382. Available at https:\/\/www.gazzettaufficiale.it\/eli\/gu\/2011\/03\/02\/50\/so\/60\/sg\/pdf. Accessed on January 3, 2023."},{"key":"10.1016\/j.ejim.2023.02.002_bib0047","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCRESAHA.121.319894","article-title":"Sex differences in cardiac rehabilitation outcomes","volume":"130","author":"Smith","year":"2022","journal-title":"Circ Res"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620523000365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620523000365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:38:38Z","timestamp":1760607518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620523000365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":47,"alternative-id":["S0953620523000365"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2023.02.002","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional outcome after cardiac rehabilitation and its association with survival in heart failure across the spectrum of ejection fraction","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2023.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}