{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:00:53Z","timestamp":1767834053662,"version":"3.49.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ejim.2023.07.026","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T22:58:27Z","timestamp":1690325907000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4844-5810","authenticated-orcid":false,"given":"Simone","family":"Marcella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Petraroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Can\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Lise","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remo","family":"Poto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Parente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-7475","authenticated-orcid":false,"given":"Francesco","family":"Palestra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-2212","authenticated-orcid":false,"given":"Leonardo","family":"Cristinziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-7124","authenticated-orcid":false,"given":"Luca","family":"Modestino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-9130","authenticated-orcid":false,"given":"Maria Rosaria","family":"Galdiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Monti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9849-4701","authenticated-orcid":false,"given":"Gianni","family":"Marone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-2093","authenticated-orcid":false,"given":"Massimo","family":"Triggiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-4657","authenticated-orcid":false,"given":"Gilda","family":"Varricchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-1898","authenticated-orcid":false,"given":"Stefania","family":"Loffredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ejim.2023.07.026_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20122976","article-title":"Multidisciplinary challenges in mastocytosis and how to address with personalized medicine approaches","volume":"20","author":"Valent","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0002","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1182\/asheducation-2018.1.127","article-title":"The new tool \"KIT\" in advanced systemic mastocytosis","volume":"2018","author":"Shomali","year":"2018","journal-title":"Hematol. Am Soc Hematol Educ Progr."},{"issue":"5","key":"10.1016\/j.ejim.2023.07.026_bib0003","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.4049\/jimmunol.163.5.2799","article-title":"Stem cell factor is localized in, released from, and cleaved by human mast cells","volume":"163","author":"de Paulis","year":"1999","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0004","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12016-017-8619-2","article-title":"Mastocytosis: from a molecular point of view","volume":"54","author":"Komi","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"issue":"2","key":"10.1016\/j.ejim.2023.07.026_bib0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/IR:34:2:97","article-title":"Development, migration, and survival of mast cells","volume":"34","author":"Okayama","year":"2006","journal-title":"Immunol Res"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0006","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1472-8206.2005.00390.x","article-title":"Stem cell factor expression, mast cells and inflammation in asthma","volume":"20","author":"Da Silva","year":"2006","journal-title":"Fundam Clin Pharmacol"},{"issue":"11","key":"10.1016\/j.ejim.2023.07.026_bib0007","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood-2016-09-731893","article-title":"Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts","volume":"129","author":"Valent","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.ejim.2023.07.026_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5836476","article-title":"Altered metabolism of phospholipases, diacylglycerols, endocannabinoids, and n-acylethanolamines in patients with mastocytosis","volume":"2019","author":"Ferrara","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.ejim.2023.07.026_bib0009","first-page":"620","article-title":"Mast cell: a multi-functional master cell","volume":"6","author":"Krystel-Whittemore","year":"2015","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0010","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.3390\/ijms20081828","article-title":"Superantigenic activation of human cardiac mast cells","volume":"20","author":"Varricchi","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.ejim.2023.07.026_bib0011","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.jaci.2022.04.003","article-title":"Drug-induced mast cell eradication: a novel approach to treat mast cell activation disorders?","volume":"149","author":"Valent","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ejim.2023.07.026_bib0012","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.3389\/fimmu.2018.02601","article-title":"The Pleiotropic immunomodulatory functions of IL-33 and its implications in tumor immunity","volume":"9","author":"Afferni","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0013","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/13543784.2019.1555237","article-title":"Prostaglandin D(2) receptor antagonists in allergic disorders: safety, efficacy, and future perspectives","volume":"28","author":"Marone","year":"2019","journal-title":"Expert Opin Investig Drugs"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0014","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.it.2020.06.006","article-title":"Cardiac mast cells: underappreciated immune cells in cardiovascular homeostasis and disease","volume":"41","author":"Varricchi","year":"2020","journal-title":"Trends Immunol"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0015","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4049\/jimmunol.138.8.2611","article-title":"Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells","volume":"138","author":"Schwartz","year":"1987","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.ejim.2023.07.026_bib0016","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3390\/vaccines8020208","article-title":"HIV gp120 induces the release of proinflammatory, angiogenic, and lymphangiogenic factors from human lung mast cells","volume":"8","author":"Marone","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.ejim.2023.07.026_bib0017","doi-asserted-by":"crossref","DOI":"10.1007\/s10238-022-00861-w","article-title":"Autoantibodies to IgE can induce the release of proinflammatory and vasoactive mediators from human cardiac mast cells","author":"Poto","year":"2022","journal-title":"Clin Exp Med"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0018","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/cells10010145","article-title":"IL-33 and superantigenic activation of human lung mast cells induce the release of angiogenic and lymphangiogenic factors","volume":"10","author":"Cristinziano","year":"2021","journal-title":"Cells"},{"issue":"16","key":"10.1016\/j.ejim.2023.07.026_bib0019","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood.2019000932","article-title":"New developments in diagnosis, prognostication, and treatment of advanced systemic mastocytosis","volume":"135","author":"Reiter","year":"2020","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.iac.2016.08.017","article-title":"Mastocytosis and anaphylaxis","volume":"37","author":"Schuch","year":"2017","journal-title":"Immunol Allergy Clin North Am"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0021","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10238-021-00693-0","article-title":"Vascular endothelial growth factors and angiopoietins as new players in mastocytosis","volume":"21","author":"Marcella","year":"2021","journal-title":"Clin Exp Med"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0022","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41577-022-00735-y","article-title":"Role of thymic stromal lymphopoietin in allergy and beyond","volume":"23","author":"Ebina-Shibuya","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ejim.2023.07.026_bib0023","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.3389\/fimmu.2018.01595","article-title":"Thymic stromal lymphopoietin isoforms, inflammatory disorders, and cancer","volume":"9","author":"Varricchi","year":"2018","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0024","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/14728222.2020.1783242","article-title":"Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma","volume":"24","author":"Gauvreau","year":"2020","journal-title":"Expert Opin Ther Targets"},{"issue":"16","key":"10.1016\/j.ejim.2023.07.026_bib0025","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.2174\/0929867325666180110094542","article-title":"Novel biological therapies in severe asthma: targeting the right trait","volume":"26","author":"Varricchi","year":"2019","journal-title":"Curr Med Chem"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0026","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jaad.2018.11.059","article-title":"Tezepelumab, an anti-thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: a randomized phase 2a clinical trial","volume":"80","author":"Simpson","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.ejim.2023.07.026_bib0027","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jaci.2017.09.046","article-title":"Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci","volume":"141","author":"Martin","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0028","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/cells8080829","article-title":"Thymic stromal lymphopoietin interferes with the apoptosis of human skin mast cells by a dual strategy involving STAT5\/Mcl-1 and JNK\/Bcl-x(L)","volume":"8","author":"Hazzan","year":"2019","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.ejim.2023.07.026_bib0029","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.20062211","article-title":"Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells","volume":"204","author":"Allakhverdi","year":"2007","journal-title":"J Exp Med"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0030","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3390\/cells10082012","article-title":"Human lung-resident macrophages express and are targets of thymic stromal lymphopoietin in the tumor microenvironment","volume":"10","author":"Braile","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0031","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.4049\/jimmunol.179.4.2051","article-title":"Cutting edge: the ST2 ligand IL-33 potently activates and drives maturation of human mast cells","volume":"179","author":"Allakhverdi","year":"2007","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.ejim.2023.07.026_bib0032","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jaci.2008.10.022","article-title":"CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation","volume":"123","author":"Allakhverdi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.ejim.2023.07.026_bib0033","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1183\/09031936.00121008","article-title":"FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells","volume":"34","author":"Okayama","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejim.2023.07.026_bib0034","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2013.00461","article-title":"Mast cell-activated bone marrow mesenchymal stromal cells regulate proliferation and lineage commitment of CD34(+) progenitor cells","volume":"4","author":"Allakhverdi","year":"2013","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.ejim.2023.07.026_bib0035","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/jid.2014.198","article-title":"TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6","volume":"134","author":"Han","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ejim.2023.07.026_bib0036","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-pathmechdis-031521-042618","article-title":"New insights into the pathogenesis of mastocytosis: emerging concepts in diagnosis and therapy","volume":"18","author":"Valent","year":"2023","journal-title":"Annu Rev Pathol"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0037","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.jaip.2022.05.034","article-title":"Proposed european competence network on mastocytosis-american initiative in mast cell diseases (ECNM-AIM) response criteria in advanced systemic mastocytosis","volume":"10","author":"Gotlib","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2023.07.026_bib0038","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.3389\/fimmu.2020.02088","article-title":"Thymic stromal lymphopoietin and cancer: th2-dependent and -independent mechanisms","volume":"11","author":"Protti","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0039","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood-2013-10-534685","article-title":"A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection","volume":"124","author":"Saleh","year":"2014","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.ejim.2023.07.026_bib0040","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1182\/blood-2009-02-205237","article-title":"Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors","volume":"113","author":"Lim","year":"2009","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.ejim.2023.07.026_bib0041","doi-asserted-by":"crossref","first-page":"18250","DOI":"10.18632\/oncotarget.4213","article-title":"Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder","volume":"6","author":"Chatterjee","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0042","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.cyto.2011.03.007","article-title":"Thymic stromal lymphopoietin is expressed and produced by caspase-1\/NF-kappaB pathway in mast cells","volume":"54","author":"Moon","year":"2011","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0043","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-3565(25)24227-6","article-title":"Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase","volume":"244","author":"Caughey","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0044","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jaci.2013.04.005","article-title":"Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis","volume":"132","author":"Nagarkar","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"20","key":"10.1016\/j.ejim.2023.07.026_bib0045","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.3390\/ijms20205147","article-title":"Highly selective cleavage of TH2-promoting cytokines by the human and the mouse mast cell tryptases, indicating a potent negative feedback loop on TH2 immunity","volume":"20","author":"Fu","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.ejim.2023.07.026_bib0046","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1136\/gutjnl-2014-308876","article-title":"Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease","volume":"65","author":"Biancheri","year":"2016","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.ejim.2023.07.026_bib0047","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.jaci.2020.03.042","article-title":"Robust production of IL-33 and TSLP by lung endothelial cells in response to low-dose dsRNA stimulation","volume":"146","author":"Emi-Sugie","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.ejim.2023.07.026_bib0048","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1111\/all.13462","article-title":"Aryl hydrocarbon receptor activation by diesel exhaust particles mediates epithelium-derived cytokines expression in severe allergic asthma","volume":"73","author":"Weng","year":"2018","journal-title":"Allergy"},{"issue":"10","key":"10.1016\/j.ejim.2023.07.026_bib0049","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1084\/jem.20190701","article-title":"Impact of naturally forming human alpha\/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia","volume":"216","author":"Le","year":"2019","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0050","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","article-title":"Diagnostic value of tryptase in anaphylaxis and mastocytosis","volume":"26","author":"Schwartz","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0051","doi-asserted-by":"crossref","first-page":"1900685","DOI":"10.1183\/13993003.00685-2019","article-title":"The emerging role of mast cell proteases in asthma","volume":"54","author":"Pejler","year":"2019","journal-title":"Eur Respir J"},{"issue":"28","key":"10.1016\/j.ejim.2023.07.026_bib0052","doi-asserted-by":"crossref","first-page":"19670","DOI":"10.1074\/jbc.274.28.19670","article-title":"Human tryptases alpha and beta\/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft","volume":"274","author":"Huang","year":"1999","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0053","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0022-2836(02)00625-3","article-title":"The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region","volume":"321","author":"Marquardt","year":"2002","journal-title":"J Mol Biol"},{"issue":"6","key":"10.1016\/j.ejim.2023.07.026_bib0054","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.anai.2021.08.009","article-title":"Clinical relevance of inherited genetic differences in human tryptases: hereditary alpha-tryptasemia and beyond","volume":"127","author":"Glover","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.ejim.2023.07.026_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104273","article-title":"Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases","volume":"127","author":"Akula","year":"2022","journal-title":"Dev Comp Immunol"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0056","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bbrc.2019.08.098","article-title":"Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate","volume":"518","author":"Ahmad","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0057","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.4049\/jimmunol.1601223","article-title":"Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and neutrophil cathepsin G","volume":"198","author":"Fu","year":"2017","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.ejim.2023.07.026_bib0058","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1096\/fj.00-0273com","article-title":"Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase","volume":"15","author":"Lindstedt","year":"2001","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0059","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1074\/jbc.M112.435156","article-title":"Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation","volume":"289","author":"Roy","year":"2014","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.ejim.2023.07.026_bib0060","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/mi.2012.129","article-title":"Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation","volume":"6","author":"Waern","year":"2013","journal-title":"Mucosal Immunol"},{"issue":"17","key":"10.1016\/j.ejim.2023.07.026_bib0061","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1073\/pnas.94.17.9017","article-title":"Chymase cleavage of stem cell factor yields a bioactive, soluble product","volume":"94","author":"Longley","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0062","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1084\/jem.174.4.821","article-title":"Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase","volume":"174","author":"Mizutani","year":"1991","journal-title":"J Exp Med"},{"issue":"12","key":"10.1016\/j.ejim.2023.07.026_bib0063","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.4049\/jimmunol.177.12.8315","article-title":"Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment","volume":"177","author":"Omoto","year":"2006","journal-title":"J Immunol"},{"issue":"10","key":"10.1016\/j.ejim.2023.07.026_bib0064","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1172\/JCI46139","article-title":"Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice","volume":"121","author":"Akahoshi","year":"2011","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0065","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.4049\/jimmunol.175.4.2635","article-title":"Cytokine production by skin-derived mast cells: endogenous proteases are responsible for degradation of cytokines","volume":"175","author":"Zhao","year":"2005","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0066","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ajpath.2012.05.013","article-title":"The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis","volume":"181","author":"Piliponsky","year":"2012","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.ejim.2023.07.026_bib0067","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.jaci.2016.08.040","article-title":"Proprotein convertases generate a highly functional heterodimeric form of thymic stromal lymphopoietin in humans","volume":"139","author":"Poposki","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.ejim.2023.07.026_bib0068","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jaci.2012.04.019","article-title":"Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin","volume":"130","author":"Nagarkar","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.ejim.2023.07.026_bib0069","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.4049\/jimmunol.1100355","article-title":"Thymic stromal lymphopoietin is produced by dendritic cells","volume":"187","author":"Kashyap","year":"2011","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.ejim.2023.07.026_bib0070","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/s41590-019-0524-9","article-title":"TSLP: from allergy to cancer","volume":"20","author":"Corren","year":"2019","journal-title":"Nat Immunol"},{"issue":"21","key":"10.1016\/j.ejim.2023.07.026_bib0071","doi-asserted-by":"crossref","first-page":"e161438","DOI":"10.1172\/jci.insight.161438","article-title":"Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment","volume":"7","author":"Yao","year":"2022","journal-title":"JCI Insight"},{"issue":"645","key":"10.1016\/j.ejim.2023.07.026_bib0072","doi-asserted-by":"crossref","first-page":"eabl6960","DOI":"10.1126\/scitranslmed.abl6960","article-title":"Emerging role for thymic stromal lymphopoietin-responsive regulatory T cells in colorectal cancer progression in humans and mice","volume":"14","author":"Obata-Ninomiya","year":"2022","journal-title":"Sci Transl Med"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0073","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00262-020-02488-w","article-title":"The expression and prognostic impact of proinflammatory cytokines and their associations with carcinogens in oropharyngeal squamous cell carcinoma","volume":"69","author":"Lin","year":"2020","journal-title":"Cancer Immunol Immunother"},{"issue":"67","key":"10.1016\/j.ejim.2023.07.026_bib0074","doi-asserted-by":"crossref","first-page":"32795","DOI":"10.18632\/oncotarget.25997","article-title":"Thymic stromal lymphopoietin in human pancreatic ductal adenocarcinoma: expression and prognostic significance","volume":"9","author":"Vizio","year":"2018","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.ejim.2023.07.026_bib0075","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1172\/JCI83724","article-title":"Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis","volume":"126","author":"Demehri","year":"2016","journal-title":"J Clin Invest"},{"issue":"13","key":"10.1016\/j.ejim.2023.07.026_bib0076","doi-asserted-by":"crossref","first-page":"16840","DOI":"10.18632\/oncotarget.7614","article-title":"Thymic stromal lymphopoietin (TSLP) inhibits human colon tumor growth by promoting apoptosis of tumor cells","volume":"7","author":"Yue","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejim.2023.07.026_bib0077","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fimmu.2017.00424","article-title":"Are mast cells MASTers in Cancer?","volume":"8","author":"Varricchi","year":"2017","journal-title":"Front Immunol"},{"issue":"18","key":"10.1016\/j.ejim.2023.07.026_bib0078","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.3390\/ijms20184397","article-title":"Future needs in mast cell biology","volume":"20","author":"Varricchi","year":"2019","journal-title":"Int J Mol Sci"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620523002571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620523002571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:39:52Z","timestamp":1760607592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620523002571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":78,"alternative-id":["S0953620523002571"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2023.07.026","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2023.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}]}}