{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:51:22Z","timestamp":1784641882181,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["LX22NPO5104"],"award-info":[{"award-number":["LX22NPO5104"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo zdravotnictv\u00ed \u010cesk\u00e9 republiky","doi-asserted-by":"publisher","award":["NV 19-09-00125"],"award-info":[{"award-number":["NV 19-09-00125"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo zdravotnictv\u00ed \u010cesk\u00e9 republiky","doi-asserted-by":"publisher","award":["NU 22-02-00130"],"award-info":[{"award-number":["NU 22-02-00130"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","ejinme.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ejim.2024.04.020","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T13:43:40Z","timestamp":1714571020000},"page":"102-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Iron deficiency and all-cause mortality after myocardial infarction"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-8460","authenticated-orcid":false,"given":"Dominik","family":"Jen\u010da","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-7078","authenticated-orcid":false,"given":"Vojt\u011bch","family":"Melenovsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolana","family":"Mr\u00e1zkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"\u0160ramko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kotr\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"\u017del\u00edzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u011bra","family":"Ad\u00e1mkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Pi\u0165ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-526X","authenticated-orcid":false,"given":"Peter","family":"Wohlfahrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejim.2024.04.020_bib0001","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.celrep.2012.11.029","article-title":"Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis","volume":"3","author":"Rensvold","year":"2013","journal-title":"Cell Rep"},{"issue":"40","key":"10.1016\/j.ejim.2024.04.020_bib0002","doi-asserted-by":"crossref","first-page":"20827","DOI":"10.1074\/jbc.M116.727701","article-title":"Iron deprivation induces transcriptional regulation of mitochondrial biogenesis","volume":"291","author":"Rensvold","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejim.2024.04.020_bib0003","article-title":"Prevalence and associated factors of iron deficiency and iron deficiency anemia among under-5 children: a systematic review and meta-analysis","volume":"9","author":"Gedfie","year":"2022","journal-title":"Glob Pediatr Health"},{"issue":"1","key":"10.1016\/j.ejim.2024.04.020_bib0004","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/eurheartj\/ehac569","article-title":"Iron deficiency and cardiovascular disease","volume":"44","author":"Savarese","year":"2023","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.ejim.2024.04.020_bib0005","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cardfail.2023.03.025","article-title":"Iron deficiency in heart failure: a scientific statement from the heart failure society of America","volume":"29","author":"Beavers","year":"2023","journal-title":"J Card Fail"},{"issue":"25","key":"10.1016\/j.ejim.2024.04.020_bib0006","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N Engl J Med"},{"issue":"48","key":"10.1016\/j.ejim.2024.04.020_bib0007","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1093\/eurheartj\/ehad586","article-title":"Efficacy of ferric carboxymaltose in heart failure with iron deficiency: an individual patient data meta-analysis","volume":"44","author":"Ponikowski","year":"2023","journal-title":"Eur Heart J"},{"issue":"36","key":"10.1016\/j.ejim.2024.04.020_bib0008","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.ejim.2024.04.020_bib0009","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jacc.2021.11.039","article-title":"Criteria for iron deficiency in patients with heart failure","volume":"79","author":"Masini","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.ejim.2024.04.020_bib0010","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1161\/CIR.0000000000000509","volume":"136","author":"Yancy","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2024.04.020_bib0011","unstructured":"Kalra PR, Cleland JGF, Petrie MC, Thomson EA, Kalra PA, Squire IB, Ahmed FZ, Al-Mohammad A, Cowburn PJ, Foley PWX, Graham FJ, Japp AG, Lane RE, Lang NN, Ludman AJ, Macdougall IC, Pellicori P, Ray R, Robertson M, Seed A, Ford I, Kalra PR, Cleland JGF, Petrie MC, Thomson EA, Kalra PA, Squire IB, Ahmed FZ, Al-Mohammad A, Cowburn PJ, Foley PWX, Graham FJ, Japp AG, Lane RE, Lang NN, Ludman AJ, Macdougall IC, Pellicori P, Ray R, Robertson M, Seed A, Ford I, Boon N, Amoils S, Chapman C, Diness TG, McMurray J, Mindham R, Sandu P, Strom CC, Travers M, Wilcox R, Struthers A, Mark P, Weir C, Cowan E, Turner C, Austin R, Rogers P, Chandrasekaran B, Fraile E, Kyeremeh L, McGregor L, Osmanska J, Meyer B, Ahmad F, Fisher J, Summersgill C, Adeniji K, Chinnadurai R, Massimo L, Hardman C, Sykes D, Frank S, Smith S, Anwar M, Whittington B, Sookhoo V, Lyons S, Middle J, Housley K, Clark A, Bulemfu J, Critoph C, Chong V, Wood S, Szwejkowski B, Lang C, Duff J, MacDonald S, Schiff R, Donnelly P, Nageh T, Kunhunny S, Gardner R, McAdam M, McPherson E, Banerjee P, Sear E, Edwards N, Glover J, Murphy C, Cooke J, Spencer C, Francis M, Matthews I, McKie H, Marshall A, Large J, Stratford J, Clifford P, Boos C, Keeling P, Hughes D, Wong A, Jones D, James A, Williams R, Leslie S, Finlayson J, Hannah A, Campbell P, Walsh J, Quinn J, Piper S, Patale S, Gupta P, Sim V, Knibbs L, Lyons K, Dixon L, Petrie C, Wong Y-k, Labinjoh C, Duckett S, Massey I, Savage H, Matias S, Ramirez J, Manisty C, Hussain I, Sankaranarayanan R, Davis G, McClure S, Baxter J, Wicks E, Sobolewska J, Murphy J, Elzayat A, Cooke A, Wright J, Williams S, Muthumala A, Chaggar P, Webber S, Ellis G, Welch M, Bulugahapitiya S, Jackson T, Pakrashi T, Bakhai A, Krishnamurthy V, Gamma R, Ellery S, Jenkins G, Thomas G, Nightingale A, Greenlaw N, Wetherall K, Clarke R, Graham C, Kean S, Stevenson A, Wilson R, Boyle S, McHugh J, Hall L, Woollard J, Brunton C, Dinnett E, Reid A, Howe S, Nicholls J, Cunnington A, Douglas E, Fegen M, Jones M, McGowan S, Ross B, Surtees P, Stuart D. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet North Am Ed 2022;400(10369):2199\u2013209."},{"key":"10.1016\/j.ejim.2024.04.020_bib0012","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijcard.2020.12.021","article-title":"Iron deficiency for prognosis in acute coronary syndrome - A systematic review and meta-analysis","volume":"328","author":"Reinhold","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2024.04.020_bib0013","unstructured":"Obradovic D., Loncar G., Zeymer U., P\u00f6ss J., Feistritzer H.J., Freund A., Jobs A., Fuernau G., Desch S., Ceglarek U., Isermann B., von Haehling S., Anker S.D., B\u00fcttner P., Thiele H. Impact of anaemia and iron deficiency on outcomes in cardiogenic shock complicating acute myocardial infarction.n\/a(n\/a)."},{"issue":"8","key":"10.1016\/j.ejim.2024.04.020_bib0014","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.bbagen.2010.03.011","article-title":"Serum ferritin: past, present and future","volume":"1800","author":"Wang","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"10.1016\/j.ejim.2024.04.020_bib0015","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1039\/C3MT00347G","article-title":"Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells","volume":"6","author":"Kell","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.ejim.2024.04.020_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111893","article-title":"Intravenous ferric carboxymaltose does not provide benefits in reperfused acute myocardial infarction in the rat with normal iron status","volume":"141","author":"Paterek","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ejim.2024.04.020_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1051995","article-title":"Trajectories and determinants of left ventricular ejection fraction after the first myocardial infarction in the current era of primary coronary interventions","volume":"9","author":"Wohlfahrt","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ejim.2024.04.020_bib0018","doi-asserted-by":"crossref","unstructured":"Thygesen K., Alpert J.S., Jaffe A.S., Chaitman B.R., Bax J.J., Morrow D.A., White H.D. Fourth Universal Definition of Myocardial Infarction (2018). 2018;138(20):e618\u201351.","DOI":"10.1161\/CIR.0000000000000617"},{"issue":"22","key":"10.1016\/j.ejim.2024.04.020_bib0019","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1001\/jama.291.22.2727","article-title":"A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry","volume":"291","author":"Eagle","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2024.04.020_bib0020","first-page":"ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes: developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejim.2024.04.020_bib0021","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.amjcard.2021.12.022","article-title":"Relation of iron status to prognosis after acute coronary syndrome","volume":"168","author":"G\u00fcrg\u00f6ze","year":"2022","journal-title":"Am J Cardiol"},{"issue":"9","key":"10.1016\/j.ejim.2024.04.020_bib0022","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015480","article-title":"Iron metabolism contributes to prognosis in coronary artery disease: prognostic value of the soluble transferrin receptor within the atherogene study","volume":"9","author":"Weidmann","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.ejim.2024.04.020_bib0023","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ajcp\/84.5.649","article-title":"Acute changes in iron metabolism following myocardial infarction","volume":"84","author":"Griffiths","year":"1985","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"10.1016\/j.ejim.2024.04.020_bib0024","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0002-8703(75)90115-5","article-title":"Ferrokinetic studies in acute myocardial infarction","volume":"90","author":"Barash","year":"1975","journal-title":"Am Heart J"},{"issue":"7","key":"10.1016\/j.ejim.2024.04.020_bib0025","first-page":"567","article-title":"Implications of iron deficiency in STEMI patients and in a murine model of myocardial infarction","volume":"6","author":"Inserte","year":"2021","journal-title":"JACC"},{"issue":"9","key":"10.1016\/j.ejim.2024.04.020_bib0026","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/ATVBAHA.117.309757","article-title":"The effect of iron status on risk of coronary artery disease","volume":"37","author":"Gill","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.ejim.2024.04.020_bib0027","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1038\/s41598-022-06694-7","article-title":"Publisher Correction: abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation","volume":"12","author":"Frise","year":"2022","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ejim.2024.04.020_bib0028","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijcard.2014.02.016","article-title":"Positive effect of intravenous iron-oxide administration on left ventricular remodelling in patients with acute ST-elevation myocardial infarction - a cardiovascular magnetic resonance (CMR) study","volume":"173","author":"Florian","year":"2014","journal-title":"Int J Cardiol"},{"issue":"9","key":"10.1016\/j.ejim.2024.04.020_bib0029","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005840","article-title":"Competing risks of cardiovascular versus noncardiovascular death during long-term follow-up after acute coronary syndromes","volume":"6","author":"Fanaroff","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.ejim.2024.04.020_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/biom8030060","article-title":"Adverse outcome prediction of iron deficiency in patients with acute coronary syndrome","volume":"8","author":"Zeller","year":"2018","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.ejim.2024.04.020_bib0031","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s44161-022-00034-8","article-title":"Hepcidin: looking back at two decades of progress","volume":"1","author":"Ganz","year":"2022","journal-title":"Nature Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.ejim.2024.04.020_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/biom8030043","article-title":"Prognostic value of iron-homeostasis regulating peptide hepcidin in coronary heart disease-evidence from the large atherogene study","volume":"8","author":"Zeller","year":"2018","journal-title":"Biomolecules"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620524001808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620524001808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T12:07:44Z","timestamp":1731067664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620524001808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":32,"alternative-id":["S0953620524001808"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2024.04.020","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron deficiency and all-cause mortality after myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2024.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}]}}