{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:16:50Z","timestamp":1791231410042,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","ejinme.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ejim.2024.06.008","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T16:08:43Z","timestamp":1718467723000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Red flags for clinical suspicion of eosinophilic granulomatosis with polyangiitis (EGPA)"],"prefix":"10.1016","volume":"128","author":[{"given":"R.","family":"Solans-Laqu\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"R\u00faa-Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blanco Aparicio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Garc\u00eda Moguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-2285","authenticated-orcid":false,"given":"R.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"P\u00e9rez Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Noblejas Mozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Labrador Horrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"\u00c1lvaro-Gracia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Domingo Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Espigol-Frigol\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"S\u00e1nchez-Toril L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Ortiz Sanju\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Arismendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-0938","authenticated-orcid":false,"given":"M.C.","family":"Cid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2024.06.008_bib0001","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103219","article-title":"Eosinophilic granulomatosis with polyangiitis: a review","volume":"22","author":"White","year":"2023","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.ejim.2024.06.008_bib0003","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.alit.2019.06.004","article-title":"Update on eosinophilic granulomatosis with polyangiitis","volume":"68","author":"Furuta","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.ejim.2024.06.008_bib0004","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.3390\/jcm11092573","article-title":"Systematic review and metaanalysis of worldwide incidence and prevalence of Antineutrophil Cytoplasmic Antibody (ANCA) associated vasculitis","volume":"11","author":"Redondo-Rodriguez","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.ejim.2024.06.008_bib0005","first-page":"338","article-title":"Familial Churg-Strauss syndrome in a sister and brother","volume":"14","author":"Alyasin","year":"2015","journal-title":"Iran J Allergy Asthma Immunol"},{"issue":"Suppl 103","key":"10.1016\/j.ejim.2024.06.008_bib0006","first-page":"40","article-title":"Employment, work disability and quality of life in patients with ANCA-associated vasculitides. The EXPOVAS study","volume":"35","author":"Benarous","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0007","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1007\/s10067-021-05783-8","article-title":"Burden of illness associated with eosinophilic granulomatosis with polyangiitis: a systematic literature review and meta-analysis","volume":"40","author":"Jakes","year":"2021","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0008","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1164\/rccm.202005-1628SO","article-title":"International consensus on antineutrophil cytoplasm antibodies testing in eosinophilic granulomatosis with polyangiitis","volume":"202","author":"Moiseev","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ejim.2024.06.008_bib0009","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0002-9343(91)90074-8","article-title":"Detection of autoantibodies against myeloid lysosomal enzymes: a useful adjunct to classification of patients with biopsy-proven necrotizing arteritis","volume":"91","author":"Cohen Tervaert","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/j.ejim.2024.06.008_bib0010","doi-asserted-by":"crossref","DOI":"10.1080\/20018525.2022.2040707","article-title":"Eosinophilic airway diseases: basic science, clinical manifestations and future challenges","author":"Janson","year":"2022","journal-title":"Eur Clin Respir J"},{"key":"10.1016\/j.ejim.2024.06.008_bib0011","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejim.2021.08.021","article-title":"Response to mepolizumab according to disease manifestations in patients with eosinophilic granulomatosis with polyangiitis","volume":"95","author":"R\u00edos-Garc\u00e9s","year":"2022","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ejim.2024.06.008_bib0012","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41584-023-00958-w","article-title":"Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis","volume":"19","author":"Emmi","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0013","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000009309","article-title":"Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA","author":"Nishi","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.ejim.2024.06.008_bib0014","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1002\/art.21250","article-title":"Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome","volume":"52","author":"Sinico","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejim.2024.06.008_bib0015","doi-asserted-by":"crossref","first-page":"632","DOI":"10.7326\/0003-4819-143-9-200511010-00006","article-title":"Antineutrophil cytoplasmic antibodies and the churg\u2013strauss syndrome","volume":"143","author":"Sabl\u00e9-Fourtassou","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejim.2024.06.008_bib0016","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.rdc.2010.05.003","article-title":"Clinical manifestations and treatment of churg-strauss syndrome","volume":"36","author":"Baldini","year":"2010","journal-title":"Rheumatic Dis Clinics North Am"},{"key":"10.1016\/j.ejim.2024.06.008_bib0017","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/art.41982","article-title":"2022 American College of rheumatology\/European alliance of associations for rheumatology classification criteria for eosinophilic granulomatosis with polyangiitis","volume":"74","author":"Grayson","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0018","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/art.1780330806","article-title":"The American College of Rheumatology 1990 criteria for the classification of churg-strauss syndrome (allergic granulomatosis and angiitis)","volume":"33","author":"Masi","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejim.2024.06.008_bib0019","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ad.2015.04.007","article-title":"Update of systemic vasculitides nomenclature. International chapel hill consensus conference, 2012","volume":"106","author":"Bielsa","year":"2015","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.ejim.2024.06.008_bib0020","doi-asserted-by":"crossref","unstructured":"Fries J.F., Hunder G.G., Bloch D.A., et al. (1990) The American college of rheumatology 1990 criteria for the classification of vasculitis summary.","DOI":"10.1002\/art.1780330812"},{"key":"10.1016\/j.ejim.2024.06.008_bib0021","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/annrheumdis-2021-221794","article-title":"2022 American college of rheumatology\/european alliance of associations for rheumatology classification criteria for eosinophilic granulomatosis with polyangiitis","volume":"81","author":"Grayson","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ejim.2024.06.008_bib0022","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/bmj.328.7454.1490","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"Atkins","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.ejim.2024.06.008_bib0023","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1200\/JCO.2010.31.6414","article-title":"Level of scientific evidence underlying recommendations arising from the national comprehensive cancer network clinical practice guidelines","volume":"29","author":"Poonacha","year":"2011","journal-title":"J Clinic Oncol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0024","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ajh.26352","article-title":"World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management","volume":"97","author":"Shomali","year":"2022","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0025","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.anai.2021.08.013","article-title":"Diagnoses associated with peripheral blood eosinophilia","volume":"127","author":"Leverone","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0026","doi-asserted-by":"crossref","unstructured":"Khoury P., Akuthota P., Kwon N., Steinfeld J., Roufosse F (2023) HES and EGPA. Mayo Clin Proc 98:1054\u20131070.","DOI":"10.1016\/j.mayocp.2023.02.013"},{"key":"10.1016\/j.ejim.2024.06.008_bib0027","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006083","article-title":"Clinical characteristics and outcome of Spanish patients with ANCA-associated vasculitides Impact of the vasculitis type, ANCA specificity, and treatment on mortality and morbidity","author":"Solans-Laqu\u00e9","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ejim.2024.06.008_bib0028","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3899\/jrheum.2023-0325","article-title":"Cluster analysis to explore clinical subphenotypes of eosinophilic granulomatosis with polyangiitis","volume":"50","author":"Rubenstein","year":"2023","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0029","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1093\/rheumatology\/keaa805","article-title":"Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)","volume":"60","author":"Papo","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ejim.2024.06.008_bib0030","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.anai.2021.01.035","article-title":"Efficacy and safety of reslizumab in the treatment of eosinophilic granulomatosis with polyangiitis","volume":"126","author":"Manka","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0031","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12890-021-01397-7","article-title":"Rapid effect of benralizumab in exacerbation of severe eosinophilic asthma associated with eosinophilic granulomatosis with polyangiitis","volume":"21","author":"Mart\u00ednez-Rivera","year":"2021","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.ejim.2024.06.008_bib0032","article-title":"Rapid onset of effect of benralizumab on respiratory symptoms in a patient with eosinophilic granulomatosis with polyangiitis","volume":"30","author":"Coppola","year":"2020","journal-title":"Respir Med Case Rep"},{"key":"10.1016\/j.ejim.2024.06.008_bib0033","doi-asserted-by":"crossref","first-page":"00451","DOI":"10.1183\/23120541.00451-2020","article-title":"Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis","volume":"6","author":"Nanzer","year":"2020","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.ejim.2024.06.008_bib0034","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jaip.2020.09.054","article-title":"Benralizumab as a steroid-sparing treatment option in eosinophilic granulomatosis with polyangiitis","volume":"9","author":"Guntur","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2024.06.008_bib0035","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1016\/j.jaip.2020.05.033","article-title":"Benralizumab as a glucocorticoid-sparing treatment option for severe asthma in eosinophilic granulomatosis with polyangiitis","volume":"8","author":"Padoan","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.ejim.2024.06.008_bib0036","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.alit.2019.04.006","article-title":"Decrease in MPO-ANCA after administration of benralizumab in eosinophilic granulomatosis with polyangiitis","volume":"68","author":"Takenaka","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.ejim.2024.06.008_bib0037","unstructured":"European Medicines Agency (EMA) (2022) Nucala(R). INN-mepolizumab. Summary of Product Characteristics. . https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/nucala. Accessed 12 Dec 2023."},{"key":"10.1016\/j.ejim.2024.06.008_bib0038","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/intqhc\/mzm062","article-title":"Development of medical checklists for improved quality of patient care","volume":"20","author":"Hales","year":"2007","journal-title":"Int J Qual Health Care"},{"key":"10.1016\/j.ejim.2024.06.008_bib0039","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.3748\/wjg.v23.i48.8605","article-title":"Person-centered endoscopy safety checklist: development, implementation, and evaluation","volume":"23","author":"Dubois","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ejim.2024.06.008_bib0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1472-6963-11-211","article-title":"Systematic review of safety checklists for use by medical care teams in acute hospital settings - limited evidence of effectiveness","volume":"11","author":"Ko","year":"2011","journal-title":"BMC Health Serv Res"},{"key":"10.1016\/j.ejim.2024.06.008_bib0041","unstructured":"World Health Organization (2009) WHO Guidelines for Safe Surgery 2009: Safe Surgery Saves Lives."}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620524002474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620524002474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T11:08:34Z","timestamp":1742036914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620524002474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":41,"alternative-id":["S0953620524002474"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2024.06.008","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Red flags for clinical suspicion of eosinophilic granulomatosis with polyangiitis (EGPA)","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2024.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}]}}