{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:55:37Z","timestamp":1791406537255,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-000040"],"award-info":[{"award-number":["UL1-TR-000040"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-001079"],"award-info":[{"award-number":["UL1-TR-001079"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ejim.2025.03.037","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T11:14:43Z","timestamp":1745234083000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Aortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-9307","authenticated-orcid":false,"given":"Ashkan","family":"Abdollahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Mojarrad","family":"Sani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsima","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-9201","authenticated-orcid":false,"given":"Bruna S.","family":"Matuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Blaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin O.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath","family":"Ambale-Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-6141","authenticated-orcid":false,"given":"Jordan B.","family":"Strom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-3168","authenticated-orcid":false,"given":"Roger S.","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bluemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-9394","authenticated-orcid":false,"given":"Nasrollah","family":"Ghahramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A.C.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-0735","authenticated-orcid":false,"given":"Seamus P.","family":"Whelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2025.03.037_bib0001","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1681\/ASN.2015050542","article-title":"CKD prevalence varies across the European general population","volume":"27","author":"Br\u00fcck","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0002","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2025.03.037_bib0003","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.291.7.844","article-title":"Predictors of new-onset kidney disease in a community-based population","volume":"291","author":"Fox","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ejim.2025.03.037_bib0004","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1097\/01.ASN.0000095249.99803.85","article-title":"Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland","volume":"14","author":"Haroun","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0005","article-title":"A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American Heart Association","author":"Ndumele","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2025.03.037_bib0006","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIR.0000000000001184","article-title":"Cardiovascular-kidney-metabolic Health: a presidential advisory from the American Heart Association","volume":"148","author":"Ndumele","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2025.03.037_bib0007","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1038\/s41598-019-41841-7","article-title":"Increased aortic arch calcification and cardiomegaly is associated with rapid renal progression and Increased cardiovascular mortality in chronic kidney disease","volume":"9","author":"Chen","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ejim.2025.03.037_bib0008","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019300","article-title":"Vascular calcification as a novel risk factor for kidney function deterioration in the nonelderly","volume":"10","author":"Park","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ejim.2025.03.037_bib0009","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM199907153410302","article-title":"Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly","volume":"341","author":"Otto","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2025.03.037_bib0010","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","article-title":"Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies","volume":"111","author":"Freeman","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2025.03.037_bib0011","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1093\/ndt\/gft310","article-title":"Aortic valve calcification in chronic kidney disease","volume":"28","author":"Rattazzi","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ejim.2025.03.037_bib0012","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.amjcard.2015.02.011","article-title":"Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)","volume":"115","author":"Guerraty","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0013","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1681\/ASN.2005060627","article-title":"Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study","volume":"17","author":"Fox","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0014","first-page":"gfad116","article-title":"Chronic kidney disease is a key risk factor for aortic stenosis progression","author":"Candellier","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ejim.2025.03.037_bib0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.ki.5000417","article-title":"Traditional and emerging cardiovascular and renal risk factors: an epidemiologic perspective","volume":"70","author":"Zoccali","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.ejim.2025.03.037_bib0016","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-Ethnic Study of Atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0017","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1053\/j.ajkd.2021.03.008","article-title":"Reassessing the inclusion of race in diagnosing kidney diseases: an interim report from the NKF-ASN Task Force","volume":"78","author":"Delgado","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ejim.2025.03.037_bib0018","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C\u2013Based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2025.03.037_bib0019","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1002\/oby.23883","article-title":"Modifiable kidney disease risk factors among nondiabetic adults with obesity from the Multi-Ethnic Study of Atherosclerosis","volume":"31","author":"Harhay","year":"2023","journal-title":"obes"},{"key":"10.1016\/j.ejim.2025.03.037_bib0020","first-page":"595","article-title":"Association between coronary artery calcification progression and microalbuminuria: the MESA study","volume":"3","author":"DeFilippis","year":"2010","journal-title":"JACC: Cardiovasc Imaging"},{"key":"10.1016\/j.ejim.2025.03.037_bib0021","article-title":"Prevalence of aortic valve calcium and the long-term risk of incident severe aortic stenosis","author":"Whelton","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.ejim.2025.03.037_bib0022","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1148\/radiol.2341040439","article-title":"Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and coronary artery risk Development in Young adults (CARDIA) study","volume":"234","author":"Carr","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.ejim.2025.03.037_bib0023","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.acra.2005.09.090","article-title":"Reproducibility of CT measurements of aortic valve calcification, mitral annulus calcification, and aortic wall calcification in the multi-ethnic study of atherosclerosis","volume":"13","author":"Budoff","year":"2006","journal-title":"Acad Radiol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0024","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/jhh.2013.1","article-title":"Blood pressure and chronic kidney disease progression in a multi-racial cohort: the Multi-Ethnic Study of Atherosclerosis","volume":"27","author":"Bloomfield","year":"2013","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.ejim.2025.03.037_bib0025","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ekir.2022.03.018","article-title":"Plasma biomarkers as risk factors for incident CKD","volume":"7","author":"Sarnak","year":"2022","journal-title":"Kidney International Reports"},{"key":"10.1016\/j.ejim.2025.03.037_bib0026","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.ajkd.2007.05.020","article-title":"Kidney function and aortic valve and mitral annular calcification in the Multi-ethnic Study of Atherosclerosis (MESA)","volume":"50","author":"Ix","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ejim.2025.03.037_bib0027","article-title":"Aortic arch calcification predicts the renal function progression in patients with stage 3 to 5 chronic kidney disease","author":"Li","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ejim.2025.03.037_bib0028","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/ndt\/gfac272","article-title":"Coronary artery calcium and risk of chronic kidney disease in young and middle-aged adults","volume":"38","author":"Kim","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ejim.2025.03.037_bib0029","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.CIR.0000135469.82545.D0","article-title":"Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography","volume":"110","author":"Messika-Zeitoun","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2025.03.037_bib0030","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease","volume":"29","author":"Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0031","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.amjcard.2021.06.035","article-title":"Risk markers for limited coronary artery calcium in persons with significant aortic valve calcium (From the Multi-ethnic Study of Atherosclerosis)","volume":"156","author":"Razavi","year":"2021","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0032","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7326\/M20-0529","article-title":"Conversion of urine protein-creatinine ratio or urine dipstick protein to urine albumin-creatinine ratio for use in chronic Kidney disease screening and prognosis : an individual participant-based meta-analysis","volume":"173","author":"Sumida","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejim.2025.03.037_bib0033","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0003-4975(02)04312-6","article-title":"Progression of aortic valve stenosis: tGF-\u03b21 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis","volume":"75","author":"Jian","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ejim.2025.03.037_bib0034","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41581-022-00590-z","article-title":"The fibrogenic niche in kidney fibrosis: components and mechanisms","volume":"18","author":"Li","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0035","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.ijcard.2014.07.199","article-title":"Increased expression of cystatin C and transforming growth factor \u03b2-1 in calcific aortic valves","volume":"176","author":"Yetkin","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0036","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ejim.2025.03.037_bib0037","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.kint.2022.09.020","article-title":"Defining measures of kidney function in observational studies using routine health care data: methodological and reporting considerations","volume":"103","author":"Carrero","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.ejim.2025.03.037_bib0038","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1475-6773.2005.00482.x","article-title":"Failure of ICD-9-CM codes to identify patients with comorbid chronic kidney disease in diabetes","volume":"41","author":"Kern","year":"2006","journal-title":"Health Serv Res"},{"key":"10.1016\/j.ejim.2025.03.037_bib0039","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa2025845","article-title":"Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes","volume":"383","author":"Bakris","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2025.03.037_bib0040","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in patients with chronic kidney disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejim.2025.03.037_bib0041","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa2204233","article-title":"Empagliflozin in patients with chronic kidney disease","volume":"388","author":"The","year":"2023","journal-title":"N Engl J Med"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620525001311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620525001311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:47:00Z","timestamp":1751456820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620525001311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":41,"alternative-id":["S0953620525001311"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2025.03.037","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2025.03.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}]}}