{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:31:10Z","timestamp":1793745070785,"version":"4.6.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["RG120172B8DFB08E"],"award-info":[{"award-number":["RG120172B8DFB08E"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["RG1221816C673852"],"award-info":[{"award-number":["RG1221816C673852"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["RG11816427B021CF"],"award-info":[{"award-number":["RG11816427B021CF"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["B83C22002820006"],"award-info":[{"award-number":["B83C22002820006"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ejim.2026.106849","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T22:25:37Z","timestamp":1774218337000},"page":"106849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Distinct miRNA expression profiles in subcutaneous and visceral adipose tissue of gastrointestinal cancer patients and their modulation based on adiposity level assessed by CT-scan"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-3459","authenticated-orcid":false,"given":"Federica","family":"Tambaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Imbimbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-3046","authenticated-orcid":false,"given":"Elena","family":"Belloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Nigri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-3174","authenticated-orcid":false,"given":"Veronica","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-9952","authenticated-orcid":false,"given":"Orietta","family":"Picconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-9403","authenticated-orcid":false,"given":"Maria Ida","family":"Amabile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-6116","authenticated-orcid":false,"given":"Maurizio","family":"Muscaritoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-0236","authenticated-orcid":false,"given":"Alessio","family":"Molfino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2026.106849_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40170-023-00329-9","article-title":"Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer","volume":"12","author":"Tambaro","year":"2024","journal-title":"Cancer Metab"},{"key":"10.1016\/j.ejim.2026.106849_bib0002","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1038\/s42255-024-01167-9","article-title":"Cancer cachexia: multilevel metabolic dysfunction","volume":"6","author":"Berriel Diaz","year":"2024","journal-title":"Nat Metab"},{"key":"10.1016\/j.ejim.2026.106849_bib0003","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ejim.2026.106849_bib0004","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1210\/endrev\/bnad015","article-title":"Update on adipose tissue and cancer","volume":"44","author":"Brown","year":"2023","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ejim.2026.106849_bib0005","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13045-023-01454-0","article-title":"Cancer cachexia: molecular mechanisms and treatment strategies","volume":"16","author":"Setiawan","year":"2023","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.ejim.2026.106849_bib0006","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41591-023-02232-8","article-title":"Body composition and lung cancer-associated cachexia in TRACERx","volume":"29","author":"Al-Sawaf","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.ejim.2026.106849_bib0007","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1016\/j.clnu.2021.08.003","article-title":"Subcutaneous, but not visceral, adipose tissue as a marker for prognosis in gastric cancer patients with cachexia","volume":"40","author":"Han","year":"2021","journal-title":"Clin Nutr"},{"key":"10.1016\/j.ejim.2026.106849_bib0008","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12986-022-00708-x","article-title":"Analysis of different adipose depot gene expression in cachectic patients with gastric cancer","volume":"19","author":"Han","year":"2022","journal-title":"Nutr Metab (L)"},{"key":"10.1016\/j.ejim.2026.106849_bib0009","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jcsm.13224","article-title":"Specific miRNAs are associated with human cancer cachexia in an organ-specific manner","volume":"14","author":"Krauss","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ejim.2026.106849_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1449197","article-title":"Circulating adipose-tissue miRNAs in gastrointestinal cancer patients and their association with the level and type of adiposity at body composition analysis","volume":"11","author":"Tambaro","year":"2024","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.ejim.2026.106849_bib0011","first-page":"235","article-title":"Metabolic and histomorphological changes of adipose tissue in cachexia","volume":"26","author":"Molfino","year":"2023","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.ejim.2026.106849_bib0012","article-title":"Muscularity and adiposity are differently associated with inflammatory and nutritional biomarkers among patients on hemodialysis and peritoneal dialysis","author":"Molfino","year":"2023","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ejim.2026.106849_bib0013","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ejim.2026.106849_bib0014","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.3390\/cancers15133324","article-title":"Expression analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as biomarkers in colorectal cancer-relationship to the body mass index","volume":"15","author":"Tesolato","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejim.2026.106849_bib0015","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s11010-020-04033-w","article-title":"MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5\/FOXC2 pathway","volume":"476","author":"Zhang","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ejim.2026.106849_bib0016","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.328955.119","article-title":"miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19","volume":"33","author":"Acharya","year":"2019","journal-title":"Genes Dev"},{"key":"10.1016\/j.ejim.2026.106849_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.09.017","article-title":"A MicroRNA linking human positive selection and metabolic disorders","volume":"183","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ejim.2026.106849_bib0018","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s11033-024-09822-w","article-title":"Exploring the versatility of miRNA-128: a comprehensive review on its role as a biomarker and therapeutic target in clinical pathways","volume":"51","author":"Israni","year":"2024","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.ejim.2026.106849_bib0019","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s13105-020-00760-2","article-title":"Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and \u03b2 cell dysfunction: the story so far","volume":"76","author":"Kaur","year":"2020","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.ejim.2026.106849_bib0020","article-title":"The impact of adipose tissue-derived miRNAs in metabolic syndrome","volume":"11","author":"Heyn","year":"2020","journal-title":"Obes Cancer Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ejim.2026.106849_bib0021","article-title":"Bioinformatics analysis of miR-181a and its role in adipogenesis, obesity, and lipid metabolism through review of literature","author":"Hongfang","year":"2023","journal-title":"Mol Biotechnol"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620526001548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953620526001548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:24:01Z","timestamp":1785961441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953620526001548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":21,"alternative-id":["S0953620526001548"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2026.106849","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct miRNA expression profiles in subcutaneous and visceral adipose tissue of gastrointestinal cancer patients and their modulation based on adiposity level assessed by CT-scan","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2026.106849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}],"article-number":"106849"}}