{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:46:17Z","timestamp":1785721577788,"version":"3.56.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejinme.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Internal Medicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ejim.2026.106984","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:06:44Z","timestamp":1780373204000},"page":"106984","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Lipoprotein(a) and risk of dementia: A propensity score\u2013matched real-world analysis from a global federated research network"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6454-2736","authenticated-orcid":false,"given":"Michele","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Askarinejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2568-3721","authenticated-orcid":false,"given":"Leandra","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-2503","authenticated-orcid":false,"given":"Claudio","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejim.2026.106984_bib0001","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1161\/ATV.0000000000000147","article-title":"Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American heart association","volume":"42","author":"Reyes-Soffer","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ejim.2026.106984_bib0002","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1055\/a-2674-5114","article-title":"Lipoprotein(a) and venous thromboembolism: association, causality, and medications","volume":"125","author":"Pfeferman","year":"2025","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ejim.2026.106984_bib0003","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1055\/a-1340-2109","article-title":"Lipoprotein(a) and cardiovascular outcomes in patients with previous myocardial infarction: a prospective cohort study","volume":"121","author":"Cao","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ejim.2026.106984_bib0004","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/23969873241293573","article-title":"Incident dementia in ischaemic stroke patients with early cardiac complications: A propensity-score matched cohort study","volume":"10","author":"Bucci","year":"2025","journal-title":"Eur Stroke J"},{"key":"10.1016\/j.ejim.2026.106984_bib0005","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70716","article-title":"Stroke-heart syndrome and risk of incident dementia among patients with first-ever ischemic stroke: A territory-wide population-based cohort study","volume":"21","author":"Tsang","year":"2025","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ejim.2026.106984_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcm.2026.01.003","article-title":"Anticoagulation therapy and dementia in atrial fibrillation: an umbrella review of systematic reviews","author":"Afzalnia","year":"2026","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.ejim.2026.106984_bib0007","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijcard.2014.10.087","article-title":"Heart failure and cognitive dysfunction","volume":"178","author":"Ampadu","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ejim.2026.106984_bib0008","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jalz.2014.10.008","article-title":"Vascular contributions to cognitive impairment and dementia including Alzheimer's disease","volume":"11","author":"Snyder","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ejim.2026.106984_bib0009","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ejim.2026.106984_bib0010","first-page":"753","article-title":"Lp(a)-lowering agents in development: A new era in tackling the burden of cardiovascular risk?","volume":"18","author":"Katsiki","year":"2025","journal-title":"Pharm (Basel)"},{"key":"10.1016\/j.ejim.2026.106984_bib0011","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1093\/eurheartj\/ehac361","article-title":"Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement","volume":"43","author":"Kronenberg","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2026.106984_bib0012","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: a systematic review and metaanalysis","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ejim.2026.106984_bib0013","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.jalz.2018.01.007","article-title":"Coronary heart disease, heart failure, and the risk of dementia: a systematic review and meta-analysis","volume":"14","author":"Wolters","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ejim.2026.106984_bib0014","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.jalz.2018.06.3061","article-title":"Stroke and dementia risk: A systematic review and meta-analysis","volume":"14","author":"Ku\u017ama","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ejim.2026.106984_bib0015","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1093\/eurheartj\/ehaf465","article-title":"Lipoprotein(a) and risk of dementia: findings from three cohort studies","volume":"46","author":"Thomas","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2026.106984_bib0016","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s10654-016-0184-0","article-title":"Is lipoprotein (a) protective of dementia?","volume":"31","author":"Kunutsor","year":"2016","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ejim.2026.106984_bib0017","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0404.1999.tb00724.x","article-title":"Increased apolipoprotein B serum concentration in Alzheimer's disease","volume":"100","author":"Caramelli","year":"1999","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.ejim.2026.106984_bib0018","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2003.12.043","article-title":"Apolipoprotein(a) null phenotype is related to a delayed age at onset of Alzheimer's disease","volume":"357","author":"Emanuele","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.ejim.2026.106984_bib0019","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2318-1-5","article-title":"Lipoprotein profile in older patients with vascular dementia and Alzheimer's disease","volume":"1","author":"Zuliani","year":"2001","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.ejim.2026.106984_bib0020","first-page":"743","article-title":"Lp(a) lipoprotein in cerebrovascular disease and dementia","volume":"41","author":"Urakami","year":"1987","journal-title":"Jpn J Psychiatry Neurol"},{"key":"10.1016\/j.ejim.2026.106984_bib0021","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3143\/geriatrics.29.559","article-title":"[Serum lipids, lipoproteins and apolipoproteins in patients with senile dementia]","volume":"29","author":"Kuriyama","year":"1992","journal-title":"Nihon Ronen Igakkai Zasshi"},{"key":"10.1016\/j.ejim.2026.106984_bib0022","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000017226","article-title":"Lipoprotein(a) phenotypes in patients with vascular dementia","volume":"11","author":"Urakami","year":"2000","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.ejim.2026.106984_bib0023","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000079200","article-title":"Relation of apolipoprotein(a) size to alzheimer's disease and vascular dementia","volume":"18","author":"Emanuele","year":"2004","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.ejim.2026.106984_bib0024","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.metabol.2003.11.020","article-title":"Small dense low-density lipoprotein and carotid atherosclerosis in relation to vascular dementia","volume":"53","author":"Watanabe","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.ejim.2026.106984_bib0025","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1479-8301.2004.00063.x","article-title":"Dual inverse effects of lipoprotein (a) on the dementia process in Japanese late-onset Alzheimer's disease","volume":"4","author":"Iwamoto","year":"2004","journal-title":"Psychogeriatrics"},{"key":"10.1016\/j.ejim.2026.106984_bib0026","first-page":"57","article-title":"Serum homocysteine, dehydroepiandrosterone sulphate and lipoprotein (a) in Alzheimer's disease and vascular dementia","volume":"4","author":"Ray","year":"2013","journal-title":"Aging Dis"},{"key":"10.1016\/j.ejim.2026.106984_bib0027","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/jnnp.72.6.732","article-title":"Lipoprotein(a), apolipoprotein E genotype, and risk of Alzheimer's disease","volume":"72","author":"Solfrizzi","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.ejim.2026.106984_bib0028","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1161\/CIRCULATIONAHA.120.045826","article-title":"Lipoprotein(a) in Alzheimer, atherosclerotic, cerebrovascular, thrombotic, and valvular disease: mendelian randomization investigation","volume":"141","author":"Larsson","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2026.106984_bib0029","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1161\/STROKEAHA.119.026872","article-title":"Causal effect of Lp(a) [Lipoprotein(a)] level on ischemic stroke and Alzheimer disease: a mendelian randomization study","volume":"50","author":"Pan","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.ejim.2026.106984_bib0030","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.jacl.2025.09.030","article-title":"Lipoprotein(a)-To test or not to test, not a dilemma but a mandate","volume":"19","author":"Fogacci","year":"2025","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.ejim.2026.106984_bib0031","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejim.2026.106984_bib0032","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.3390\/ijerph20186721","article-title":"Lipoprotein(a) as a risk factor for cardiovascular diseases: pathophysiology and treatment perspectives","volume":"20","author":"Vinci","year":"2023","journal-title":"Int J Env Res Public Health"},{"key":"10.1016\/j.ejim.2026.106984_bib0033","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11789-017-0084-1","article-title":"Lipoprotein(a) and its role in inflammation, atherosclerosis and malignancies","volume":"12","author":"Ors\u00f3","year":"2017","journal-title":"Clin Res Cardiol Suppl"},{"key":"10.1016\/j.ejim.2026.106984_bib0034","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2147\/VHRM.S555127","article-title":"Lipoprotein(a) and its role in peripheral arterial disease: a narrative review","volume":"Volume 21","author":"Mwipatayi","year":"2025","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.ejim.2026.106984_bib0035","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1055\/s-0039-1687907","article-title":"Vascular disease and dementia: lipoprotein(a) as a neglected link","volume":"45","author":"Lippi","year":"2019","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.ejim.2026.106984_bib0036","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1161\/CIRCULATIONAHA.105.608679","article-title":"Risk factors for progression of peripheral arterial disease in large and small vessels","volume":"113","author":"Aboyans","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ejim.2026.106984_bib0037","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ejim.2026.106984_bib0038","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1373\/clinchem.2006.073544","article-title":"Lipoprotein(a) in the cerebrospinal fluid of neurological patients with blood-cerebrospinal fluid barrier dysfunction","volume":"52","author":"Pepe","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.ejim.2026.106984_bib0039","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/a-2664-7887","article-title":"Comparative effectiveness research using randomized trials and observational studies: validity and feasibility considerations","volume":"126","author":"Bikdeli","year":"2026","journal-title":"Thromb Haemost"}],"container-title":["European Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362052600289X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095362052600289X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:13:59Z","timestamp":1785719639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095362052600289X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":39,"alternative-id":["S095362052600289X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejim.2026.106984","relation":{},"ISSN":["0953-6205"],"issn-type":[{"value":"0953-6205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipoprotein(a) and risk of dementia: A propensity score\u2013matched real-world analysis from a global federated research network","name":"articletitle","label":"Article Title"},{"value":"European Journal of Internal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejim.2026.106984","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.","name":"copyright","label":"Copyright"}],"article-number":"106984"}}